Chronic cerebral ischemia is accompanied by impaired function of the glymphatic system, leading to reduced clearance of metabolites and accumulation of toxic proteins (β-amyloid, tau protein). These changes aggravate neurodegeneration, contribute to the development of cognitive impairment, and promote vascular-degenerative dementia. The key mechanisms of glymphatic insufficiency include decreased arterial pulsatility, loss of aquaporin-4 polarity, and impaired cerebrospinal fluid dynamics. Promising therapeutic strategies involve restoration of vascular function, modulation of aquaporin-4, and normalization of sleep.
| Mualliflar | Ахророва Шахло Ботировна, Умарова Мехринисо Нуриддиновна, Мухсинов Мухаммад Мирзо Мирсаидович |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashriyot | Бухоро давлат тиббиёт институти |
| Nashr sanasi | 2025-10-09 |
| Jild | 6 |
| Son | 6 |
| Til | Ingliz |
| Ilmiy soha | Tibbiyot |
| Indeksga qo‘shilgan | 2026-08-26 |
хроническая ишемия мозга, глимфатическая недостаточность, когнитивные нарушения, chronic cerebral ischemia, glymphatic insufficiency, cognitive impairment, сўрункали мия ишемияси, глимфатик етишмовчилиги, когнитив бузилишлар
| APA | Ахророва Шахло Ботировна, Умарова Мехринисо Нуриддиновна, & Мухсинов Мухаммад Мирзо Мирсаидович (2025). PATHOGENETIC ROLE OF GLYMPHATIC INSUFFICIENCY IN CHRONIC CEREBRAL ISCHEMIA. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6). https://tadqiqot.uz/index.php/neurology/article/view/12518 |
|---|---|
| GOST (OAK) | Ахророва Шахло Ботировна, Умарова Мехринисо Нуриддиновна, Мухсинов Мухаммад Мирзо Мирсаидович PATHOGENETIC ROLE OF GLYMPHATIC INSUFFICIENCY IN CHRONIC CEREBRAL ISCHEMIA // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2025. – T. 6, № 6. |
| MLA | Ахророва Шахло Ботировна, Умарова Мехринисо Нуриддиновна, and Мухсинов Мухаммад Мирзо Мирсаидович. “PATHOGENETIC ROLE OF GLYMPHATIC INSUFFICIENCY IN CHRONIC CEREBRAL ISCHEMIA.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6), 2025. https://tadqiqot.uz/index.php/neurology/article/view/12518 |
| Chicago | Ахророва Шахло Ботировна, Умарова Мехринисо Нуриддиновна, and Мухсинов Мухаммад Мирзо Мирсаидович. “PATHOGENETIC ROLE OF GLYMPHATIC INSUFFICIENCY IN CHRONIC CEREBRAL ISCHEMIA.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6) (2025). https://tadqiqot.uz/index.php/neurology/article/view/12518 |
| Harvard | Ахророва Шахло Ботировна, Умарова Мехринисо Нуриддиновна, and Мухсинов Мухаммад Мирзо Мирсаидович (2025) ‘PATHOGENETIC ROLE OF GLYMPHATIC INSUFFICIENCY IN CHRONIC CEREBRAL ISCHEMIA’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6). https://tadqiqot.uz/index.php/neurology/article/view/12518 |
| BibTeX | @article{article2025,
title = {PATHOGENETIC ROLE OF GLYMPHATIC INSUFFICIENCY IN CHRONIC CEREBRAL ISCHEMIA},
author = {Ахророва Шахло Ботировна and Умарова Мехринисо Нуриддиновна and Мухсинов Мухаммад Мирзо Мирсаидович},
journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
year = {2025},
volume = {6},
number = {6},
url = {https://tadqiqot.uz/index.php/neurology/article/view/12518}
} |
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