Dopamine deficiency in parkinson`s disease and its effect on movement

Бафоева Зарина Бахтиёровна

Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research · 2025-yil

Annotatsiya

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects motor and cognition functions. The etiology of Parkinson's disease remains largely unknown, but genetic and environmental factors are believed to play a role. The neurotransmitter dopamine is implicated in regulating movement, motivation, memory, and other physiological processes. In individuals with Parkinson's disease, the loss of dopaminergic neurons leads to a reduction in dopamine levels, which causes motor impairment and may also contribute to the cognitive deficits observed in some patients. Important advances in the treatment, etiology, and pathogenesis of Parkinson's disease have been made in the past 50 years. Therefore, this review tries to explain the different possible mechanisms behind the depletion of dopamine in PD patients such as alpha-synuclein abnormalities, mitochondrial dysfunction, and 3,4-dihydroxyphenylacetaldehyde (DOPAL) toxicity, along with the current therapies we have and the ones that are in development.

Maqola ma’lumotlari
MualliflarБафоева Зарина Бахтиёровна
JurnalЖурнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research
NashriyotБухоро давлат тиббиёт институти
Nashr sanasi2025-10-08
Jild6
Son6
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-26

Maqolaning asl sahifasi

Kalit so‘zlar

болезнь Паркинсона, дофамин, нейротоксичность ДФА, альфа-синуклеин, Parkinson's disease,DOPAL neurotoxicity, alpha-synuclein,dopamine, Паркинсон касаллиги,допамин,ДОФАЛ нейротоксиклиги, алфа-синуклеин

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAБафоева Зарина Бахтиёровна (2025). DOPAMINE DEFICIENCY IN PARKINSON`S DISEASE AND ITS EFFECT ON MOVEMENT. Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6). https://tadqiqot.uz/index.php/neurology/article/view/12514
GOST (OAK)Бафоева Зарина Бахтиёровна DOPAMINE DEFICIENCY IN PARKINSON`S DISEASE AND ITS EFFECT ON MOVEMENT // Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research. – 2025. – T. 6, № 6.
MLAБафоева Зарина Бахтиёровна. “DOPAMINE DEFICIENCY IN PARKINSON`S DISEASE AND ITS EFFECT ON MOVEMENT.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6), 2025. https://tadqiqot.uz/index.php/neurology/article/view/12514
ChicagoБафоева Зарина Бахтиёровна. “DOPAMINE DEFICIENCY IN PARKINSON`S DISEASE AND ITS EFFECT ON MOVEMENT.” Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6) (2025). https://tadqiqot.uz/index.php/neurology/article/view/12514
HarvardБафоева Зарина Бахтиёровна (2025) ‘DOPAMINE DEFICIENCY IN PARKINSON`S DISEASE AND ITS EFFECT ON MOVEMENT’, Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research, 6(6). https://tadqiqot.uz/index.php/neurology/article/view/12514
BibTeX
@article{article2025,
  title = {DOPAMINE DEFICIENCY IN PARKINSON`S DISEASE AND ITS EFFECT ON MOVEMENT},
  author = {Бафоева Зарина Бахтиёровна},
  journal = {Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research},
  year = {2025},
  volume = {6},
  number = {6},
  url = {https://tadqiqot.uz/index.php/neurology/article/view/12514}
}

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