Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects motor and cognition functions. The etiology of Parkinson's disease remains largely unknown, but genetic and environmental factors are believed to play a role. The neurotransmitter dopamine is implicated in regulating movement, motivation, memory, and other physiological processes. In individuals with Parkinson's disease, the loss of dopaminergic neurons leads to a reduction in dopamine levels, which causes motor impairment and may also contribute to the cognitive deficits observed in some patients. Important advances in the treatment, etiology, and pathogenesis of Parkinson's disease have been made in the past 50 years. Therefore, this review tries to explain the different possible mechanisms behind the depletion of dopamine in PD patients such as alpha-synuclein abnormalities, mitochondrial dysfunction, and 3,4-dihydroxyphenylacetaldehyde (DOPAL) toxicity, along with the current therapies we have and the ones that are in development.
| Mualliflar | Бафоева Зарина Бахтиёровна |
|---|---|
| Jurnal | Журнал неврологии и нейрохирургических исследований / Journal of Neurology and Neurosurgical Research |
| Nashr sanasi | 2025-10-08 |
| Jild | 6 |
| Son | 6 |
| Til | Ingliz |
болезнь Паркинсона, дофамин, нейротоксичность ДФА, альфа-синуклеин, Parkinson's disease,DOPAL neurotoxicity, alpha-synuclein,dopamine, Паркинсон касаллиги,допамин,ДОФАЛ нейротоксиклиги, алфа-синуклеин
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