Clinical, laboratory, and immunological characteristics of community-acquired pneumonia in young children and markers of its severe course

Abrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, Sharipov, Alisher, Абриева, Нодира, Шойикрамов, Шоилес, Ахматалиева, Марьям, Сафаров, З, Шарипов, А, Abrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, Sharipov, Alisher

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Background. Community-acquired pneumonia (CAP) in young children remains a leading cause of morbidity and complications, necessitating early detection of clinical, laboratory, and immunological markers of severe disease. Despite the decrease in overall child mortality in recent decades, CAP remains the leading cause of death among infectious diseases in early childhood, especially in countries with economies in transition. Objective. To evaluate the analysis of clinical, laboratory, and immunological characteristics of community-acquired pneumonia in young children and identify markers most closely associated with a severe course of the disease. Materials and methods. Eighty children aged 12–36 months with confirmed CAP were examined. Clinical manifestations, respiratory function, radiographic signs, complete blood count, biochemical markers (including C-reactive protein), microbiological data, and immunity parameters (IgA, IgM, IgG, CD4+, CD8+, CD4/CD8 index) were analyzed. Patients were divided into groups with mild (n = 40) and severe (n = 40) course. Statistical analysis included Student's t-test, Mann–Whitney test, and χ² (p < 0.05). Results. The data obtained indicate that children with severe CAP exhibit a pronounced inflammatory response and immunoregulatory imbalance. Increased levels of leukocytes, neutrophils, ESR, and C-reactive protein are accompanied by a decrease in lymphocytes. Conclusions. Severe CAP was accompanied by severe respiratory failure, high fever, extensive infiltrates on radiographs, leukocytosis, neutrophilia, increased ESR and CRP, and a decrease in lymphocytes. Immunological testing revealed a decrease in CD4+ and IgA, an increase in CD8+ and IgM, and a significant decrease in the CD4/CD8 ratio. Clinical signs, inflammatory markers, and immunological markers can serve as a reliable system for the early diagnosis of severe CAP in young children.

Maqola ma’lumotlari
MualliflarAbrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, Sharipov, Alisher, Абриева, Нодира, Шойикрамов, Шоилес, Ахматалиева, Марьям, Сафаров, З, Шарипов, А, Abrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, Sharipov, Alisher
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-12-24
Jild4
Son6
Betlar148-153
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-6-148-153
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-6-148-153 · Maqolaning asl sahifasi

Kalit so‘zlar

community-acquired pneumonia, young children, clinical features, inflammatory markers, immune status, внебольничная пневмония, дети раннего возраста, клинические особенности, воспалительные маркеры, иммунный статус, jamiyatdan tashqari pnevmoniya, yosh bolalar, klinik xususiyatlar, yallig'lanish belgilari, immunitet holati

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAbrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, Sharipov, Alisher, Абриева, Нодира, Шойикрамов, Шоилес, Ахматалиева, Марьям, Сафаров, З, Шарипов, А, Abrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, & Sharipov, Alisher (2025). Clinical, laboratory, and immunological characteristics of community-acquired pneumonia in young children and markers of its severe course. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 148-153. https://doi.org/10.56121/2181-3612-2025-6-148-153
GOST (OAK)Abrieva, Nodira va b. Clinical, laboratory, and immunological characteristics of community-acquired pneumonia in young children and markers of its severe course // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 6. – P. 148-153. – DOI: 10.56121/2181-3612-2025-6-148-153.
MLAAbrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, Sharipov, Alisher, Абриева, Нодира, Шойикрамов, Шоилес, Ахматалиева, Марьям, Сафаров, З, Шарипов, А, Abrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, and Sharipov, Alisher. “Clinical, laboratory, and immunological characteristics of community-acquired pneumonia in young children and markers of its severe course.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 148-153, 2025. https://doi.org/10.56121/2181-3612-2025-6-148-153
ChicagoAbrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, Sharipov, Alisher, Абриева, Нодира, Шойикрамов, Шоилес, Ахматалиева, Марьям, Сафаров, З, Шарипов, А, Abrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, and Sharipov, Alisher. “Clinical, laboratory, and immunological characteristics of community-acquired pneumonia in young children and markers of its severe course.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 148-153 (2025). https://doi.org/10.56121/2181-3612-2025-6-148-153
HarvardAbrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, Sharipov, Alisher, Абриева, Нодира, Шойикрамов, Шоилес, Ахматалиева, Марьям, Сафаров, З, Шарипов, А, Abrieva, Nodira, Shoyikramov, Shoiles, Akhmataliyeva, Maryam, Safarov, Zafar, and Sharipov, Alisher (2025) ‘Clinical, laboratory, and immunological characteristics of community-acquired pneumonia in young children and markers of its severe course’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 148-153. https://doi.org/10.56121/2181-3612-2025-6-148-153
BibTeX
@article{abrievanodira2025,
  title = {Clinical, laboratory, and immunological characteristics of community-acquired pneumonia in young children and markers of its severe course},
  author = {Abrieva, Nodira and Shoyikramov, Shoiles and Akhmataliyeva, Maryam and Safarov, Zafar and Sharipov, Alisher and Абриева, Нодира and Шойикрамов, Шоилес and Ахматалиева, Марьям and Сафаров, З and Шарипов, А and Abrieva, Nodira and Shoyikramov, Shoiles and Akhmataliyeva, Maryam and Safarov, Zafar and Sharipov, Alisher},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {6},
  pages = {148-153},
  doi = {10.56121/2181-3612-2025-6-148-153},
  url = {https://doi.org/10.56121/2181-3612-2025-6-148-153}
}

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