Specific features of bronchial asthma associated with atopic dermatitis in children living in the Khorezm region

Mirrahimova, Maqtuba, Tashmatova, Gulnoza, Jumanazarova, Guli, Миррахимова, Мактуба, Ташматова, Гулноза, Жуманазарова, Гули, Mirrahimova, Maqtuba, Tashmatova, Gulnoza, Jumanazarova, Guli

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Bronchial asthma and atopic dermatitis occupy a leading place among chronic allergic diseases of childhood. Their prevalence worldwide shows a steady upward trend, which is associated with changes in the ecological situation, lifestyle, and the influence of urbanization. Objective: to study the clinical, immunological, and regional features of the comorbid course of bronchial asthma and atopic dermatitis in children living in the Khorezm region. Materials and Methods. The study was conducted on the basis of pediatric departments of the Khorezm region and the Department of Children’s Diseases of the Tashkent State Medical University. A total of 120 children aged 6 to 15 years, permanently residing in the Khorezm region, were included in the study. Results. The average age of onset of bronchial asthma in children with comorbid course was 5.2 ± 0.8 years, which was significantly earlier than in children with isolated asthma (7.1 ± 0.9 years, p < 0.05). Patients with BA+AD had a higher number of nocturnal coughing episodes (5.6 episodes/month on average) compared to those with isolated BA (3.1 episodes/month). The total number of exacerbations per year was also higher in children with the comorbid course (3.8 ± 0.6 vs. 2.1 ± 0.4, p < 0.01). Conclusion. In children of the Khorezm region, the comorbid course of bronchial asthma and atopic dermatitis is characterized by an earlier onset, more frequent exacerbations, and a pronounced immunological imbalance with predominance of the Th2 response, which determines a severe recurrent course and requires an individualized therapeutic approach.

Maqola ma’lumotlari
MualliflarMirrahimova, Maqtuba, Tashmatova, Gulnoza, Jumanazarova, Guli, Миррахимова, Мактуба, Ташматова, Гулноза, Жуманазарова, Гули, Mirrahimova, Maqtuba, Tashmatova, Gulnoza, Jumanazarova, Guli
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-12-24
Jild4
Son6
Betlar139-142
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-6-139-142
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-6-139-142 · Maqolaning asl sahifasi

Kalit so‘zlar

bronchial asthma, atopic dermatitis, comorbid course, intestinal microbiota, immune system, dysbiosis, Th2-immune response, allergic inflammation, pathogenesis, children, бронхиальная астма, атопический дерматит, коморбидное течение, кишечная микробиота, иммунная система, дисбиоз, Th2-иммунный ответ, аллергическое воспаление, патогенез, дети, bronxial astma, atopik dermatit, komorbid kechish, ichak mikrobiotasi, immun tizimi, disbioz, Th2-immun javob, allergik yallig’lanish, patogenez, bolalar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMirrahimova, Maqtuba, Tashmatova, Gulnoza, Jumanazarova, Guli, Миррахимова, Мактуба, Ташматова, Гулноза, Жуманазарова, Гули, Mirrahimova, Maqtuba, Tashmatova, Gulnoza, & Jumanazarova, Guli (2025). SPECIFIC FEATURES OF BRONCHIAL ASTHMA ASSOCIATED WITH ATOPIC DERMATITIS IN CHILDREN LIVING IN THE KHOREZM REGION. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 139-142. https://doi.org/10.56121/2181-3612-2025-6-139-142
GOST (OAK)Mirrahimova, Maqtuba va b. SPECIFIC FEATURES OF BRONCHIAL ASTHMA ASSOCIATED WITH ATOPIC DERMATITIS IN CHILDREN LIVING IN THE KHOREZM REGION // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 6. – P. 139-142. – DOI: 10.56121/2181-3612-2025-6-139-142.
MLAMirrahimova, Maqtuba, Tashmatova, Gulnoza, Jumanazarova, Guli, Миррахимова, Мактуба, Ташматова, Гулноза, Жуманазарова, Гули, Mirrahimova, Maqtuba, Tashmatova, Gulnoza, and Jumanazarova, Guli. “SPECIFIC FEATURES OF BRONCHIAL ASTHMA ASSOCIATED WITH ATOPIC DERMATITIS IN CHILDREN LIVING IN THE KHOREZM REGION.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 139-142, 2025. https://doi.org/10.56121/2181-3612-2025-6-139-142
ChicagoMirrahimova, Maqtuba, Tashmatova, Gulnoza, Jumanazarova, Guli, Миррахимова, Мактуба, Ташматова, Гулноза, Жуманазарова, Гули, Mirrahimova, Maqtuba, Tashmatova, Gulnoza, and Jumanazarova, Guli. “SPECIFIC FEATURES OF BRONCHIAL ASTHMA ASSOCIATED WITH ATOPIC DERMATITIS IN CHILDREN LIVING IN THE KHOREZM REGION.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 139-142 (2025). https://doi.org/10.56121/2181-3612-2025-6-139-142
HarvardMirrahimova, Maqtuba, Tashmatova, Gulnoza, Jumanazarova, Guli, Миррахимова, Мактуба, Ташматова, Гулноза, Жуманазарова, Гули, Mirrahimova, Maqtuba, Tashmatova, Gulnoza, and Jumanazarova, Guli (2025) ‘SPECIFIC FEATURES OF BRONCHIAL ASTHMA ASSOCIATED WITH ATOPIC DERMATITIS IN CHILDREN LIVING IN THE KHOREZM REGION’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 139-142. https://doi.org/10.56121/2181-3612-2025-6-139-142
BibTeX
@article{mirrahimovamaqtuba2025,
  title = {SPECIFIC FEATURES OF BRONCHIAL ASTHMA ASSOCIATED WITH ATOPIC DERMATITIS IN CHILDREN LIVING IN THE KHOREZM REGION},
  author = {Mirrahimova, Maqtuba and Tashmatova, Gulnoza and Jumanazarova, Guli and Миррахимова, Мактуба and Ташматова, Гулноза and Жуманазарова, Гули and Mirrahimova, Maqtuba and Tashmatova, Gulnoza and Jumanazarova, Guli},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {6},
  pages = {139-142},
  doi = {10.56121/2181-3612-2025-6-139-142},
  url = {https://doi.org/10.56121/2181-3612-2025-6-139-142}
}

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