Adrenal cortex hyperplasia in a newborn girl (Case Study)

Abdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, To'xtaeva, Umida, Абдукадирова, Мунира, Рахманкулова, Зухра, Ходжамова, Наргиза, Тухтаева, Умида, Abdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, To'xtaeva, Umida

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Main The pathogenesis is linked to impaired cortisol synthesis, a deficiency of which, through a feedback loop, stimulates ACTH secretion, leading to adrenal cortex hyperplasia and increased steroidogenesis. Moreover, the levels of not only those steroids formed in the stages preceding the blocked stage increase, but also those whose synthesis pathway bypasses the blocked stage. In many forms of congenital adrenal hyperplasia, adrenal androgen secretion also increases, leading to virilization in female patients. Therefore, congenital adrenogenital hyperplasia was previously called congenital adrenogenital syndrome. Objective. The objective is to present a clinical case of congenital adrenal cortical dysfunction, the virilizing – salt-wasting form, in a newborn infant. Methods. We present a clinical case of congenital adrenal cortical dysfunction, the virilizing – salt-wasting form, observed by the authors in a newborn infant. An analysis was performed on the patient's inpatient medical records and the results of clinical, laboratory, and instrumental examination methods. Results. Congenital adrenal cortical dysfunction, the virilizing – salt-wasting form, belongs to the group of genetically determined electrolyte balance disorders. These arise from impaired sodium ion reabsorption in the renal tubules due to the low sensitivity of tubular epithelial receptors to aldosterone. The clinical presentation is variable, and the disease may proceed with a risk of fatal outcome due to severe salt loss and pronounced hyperkalemia. Key manifestations include polyuria, polydipsia, vomiting, failure to thrive (physical developmental delay), arterial hypotension, and episodes of dehydration. We present the specific features of the clinical course of congenital adrenal cortical dysfunction, the virilizing – salt-wasting form, as well as the dynamics of laboratory parameters before and during treatment in the newborn infant. Conclusion. In newborns presenting with persistent hyperkalemia amidst progressive hypotrophy (failure to thrive), congenital adrenal cortical dysfunction should be ruled out. The presented clinical case will allow clinicians to broaden their perspective on the issue of hyperkalemia and the characteristics of clinical manifestations of rare tubulopathies, facilitating timely diagnosis and the correct selection of management strategy.

Maqola ma’lumotlari
MualliflarAbdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, To'xtaeva, Umida, Абдукадирова, Мунира, Рахманкулова, Зухра, Ходжамова, Наргиза, Тухтаева, Умида, Abdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, To'xtaeva, Umida
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-12-24
Jild4
Son6
Betlar122-127
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-6-122-127
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-6-122-127 · Maqolaning asl sahifasi

Kalit so‘zlar

congenital adrenal cortex hyperplasia, hypoxic damage to the central nervous system, premature baby, врождённая гиперплазия коры надпочечников, гипоксическое поражение центральной нервной системы, недоношенный ребёнок, adrenal korteksning tug'ma giper plaziyasi, markaziy asab tizimining gipoksik shikastlanishi, erta tug'ilgan chaqaloq

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAbdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, To'xtaeva, Umida, Абдукадирова, Мунира, Рахманкулова, Зухра, Ходжамова, Наргиза, Тухтаева, Умида, Abdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, & To'xtaeva, Umida (2025). ADRENAL CORTEX HYPERPLASIA IN A NEWBORN GIRL (Case Study). Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 122-127. https://doi.org/10.56121/2181-3612-2025-6-122-127
GOST (OAK)Abdukadirova, Munira va b. ADRENAL CORTEX HYPERPLASIA IN A NEWBORN GIRL (Case Study) // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 6. – P. 122-127. – DOI: 10.56121/2181-3612-2025-6-122-127.
MLAAbdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, To'xtaeva, Umida, Абдукадирова, Мунира, Рахманкулова, Зухра, Ходжамова, Наргиза, Тухтаева, Умида, Abdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, and To'xtaeva, Umida. “ADRENAL CORTEX HYPERPLASIA IN A NEWBORN GIRL (Case Study).” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 122-127, 2025. https://doi.org/10.56121/2181-3612-2025-6-122-127
ChicagoAbdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, To'xtaeva, Umida, Абдукадирова, Мунира, Рахманкулова, Зухра, Ходжамова, Наргиза, Тухтаева, Умида, Abdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, and To'xtaeva, Umida. “ADRENAL CORTEX HYPERPLASIA IN A NEWBORN GIRL (Case Study).” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 122-127 (2025). https://doi.org/10.56121/2181-3612-2025-6-122-127
HarvardAbdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, To'xtaeva, Umida, Абдукадирова, Мунира, Рахманкулова, Зухра, Ходжамова, Наргиза, Тухтаева, Умида, Abdukadirova, Munira, Raxmankulova, Zuxra, Xojamova, Nargiza, and To'xtaeva, Umida (2025) ‘ADRENAL CORTEX HYPERPLASIA IN A NEWBORN GIRL (Case Study)’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 122-127. https://doi.org/10.56121/2181-3612-2025-6-122-127
BibTeX
@article{abdukadirovamunira2025,
  title = {ADRENAL CORTEX HYPERPLASIA IN A NEWBORN GIRL (Case Study)},
  author = {Abdukadirova, Munira and Raxmankulova, Zuxra and Xojamova, Nargiza and To'xtaeva, Umida and Абдукадирова, Мунира and Рахманкулова, Зухра and Ходжамова, Наргиза and Тухтаева, Умида and Abdukadirova, Munira and Raxmankulova, Zuxra and Xojamova, Nargiza and To'xtaeva, Umida},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {6},
  pages = {122-127},
  doi = {10.56121/2181-3612-2025-6-122-127},
  url = {https://doi.org/10.56121/2181-3612-2025-6-122-127}
}

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