Relevance. Respiratory syncytial virus (RSV) infection remains one of the leading causes of acute respiratory diseases in infants and young children, representing a serious medical and socio-economic problem worldwide. Its high contagiousness, pronounced seasonality, and severe course in newborns have a significant impact on childhood morbidity and mortality rates. Objective. To assess the current state of the RSV infection problem in children, including its epidemiological, clinical, and socio-economic aspects, as well as to analyze new advances in prevention, diagnosis, and therapy — particularly the introduction of monoclonal antibodies and vaccine platforms. Materials and Methods. An analytical review was conducted based on national and international sources from 2019–2025, covering materials from the World Health Organization, results of multicenter cohort and randomized clinical studies, as well as data from meta-analyses and systematic reviews published in leading scientific databases (PubMed, Scopus, WHO Global RSV Surveillance). Results. RSV infection continues to be one of the major causes of acute respiratory diseases in infants and young children. According to WHO data, more than 33 million cases are registered annually, of which approximately 3.6 million require hospitalization, and up to 100,000 result in death. The highest burden of the disease falls on infants during the first six months of life, particularly among premature newborns and patients with congenital heart defects or bronchopulmonary dysplasia. In recent years, significant progress has been achieved in prevention: long-acting monoclonal antibodies (nirsevimab), vaccines for pregnant women (Abrysvo, Arexvy), and the development of mRNA vaccines have been introduced. These advances open new opportunities to reduce the global burden of RSV-related disease. Nevertheless, therapeutic approaches remain largely symptomatic, while early laboratory diagnostics and the rational use of healthcare resources require further improvement. Conclusions. RSV infection represents a major medical and social problem characterized by high contagiousness, seasonality, and severe complications in infants. Strengthening epidemiological surveillance, implementing highly sensitive diagnostic methods, and expanding vaccination programs are key strategies for reducing mortality and hospitalization rates. Recent advances in vaccinology and monoclonal antibody therapy form the foundation for a comprehensive preventive strategy aimed at protecting the most vulnerable groups of the pediatric population.
| Mualliflar | Babadjanova, Faniya, Zaidova, Dilnura, Бабаджанова, Фания, Заидова, Дилнура, Babadjanova, Faniya, Zaidova, Dilnura |
|---|---|
| Jurnal | Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi |
| Nashr sanasi | 2025-12-24 |
| Jild | 4 |
| Son | 6 |
| Betlar | 143-147 |
| Til | Rus |
| DOI | 10.56121/2181-3612-2025-6-143-147 |
DOI: 10.56121/2181-3612-2025-6-143-147 · Maqolaning asl sahifasi
respiratory syncytial virus, RSV infection, bronchiolitis, pneumonia, young children, infants, nirsevimab, респираторно-синцитиальный вирус, РСВ-инфекция, бронхиолит, пневмония, дети раннего возраста, respiratorno-sintsitsial virus, RSV-infeksiya, bronxiolit, pnevmoniya, erta yoshdagi bolalar
Background. Community-acquired pneumonia (CAP) in young children remains a leading cause of morbidity and complications, necessitating early detection of clinical, laboratory, and immunological markers of severe…
Bronchial asthma and atopic dermatitis occupy a leading place among chronic allergic diseases of childhood. Their prevalence worldwide shows a steady upward trend, which is associated with changes in the ecological…
Relevance. At present, there is a growing interest in studying the role of the central and especially the autonomic nervous system in the development and pathogenetic course of hypertension. However, many aspects of…
Respiratory distress syndrome (P22.0; ICD-10) is a condition associated with lung immaturity and surfactant deficiency in neonates born prematurely. Treatment of RDS remains a key component of neonatal intensive care…
Non–ST-segment elevation myocardial infarction (NSTEMI) is one of the most common forms of acute coronary syndromes and represents a leading cause of cardiovascular morbidity and mortality. In recent years, a…
Main The pathogenesis is linked to impaired cortisol synthesis, a deficiency of which, through a feedback loop, stimulates ACTH secretion, leading to adrenal cortex hyperplasia and increased steroidogenesis. Moreover…
The study of the pharmacokinetics of antibiotics on model objects makes it possible to optimize their dosage and method of administration for further clinical practice. Aim. The aim of this study was to compare…
Most literature devoted to analyzing the course of novel coronavirus infection in pregnant women, women in labor, and newborns has assessed the somatic status and morphofunctional characteristics of children born to…
Case: A 1-year-old female patient presented for the workup of a cystic abdominal lesion that was first discovered at 6 to 7 months of life. A first CT scan of the abdomen and retroperitoneal space showed a cystic mass…
This article is devoted to the study of clinical and functional features in children with bronchial asthma combined with gastrointestinal tract disorders. The work reviews current data on the prevalence of comorbid…
Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar