This article is devoted to the study of clinical and functional features in children with bronchial asthma combined with gastrointestinal tract disorders. The work reviews current data on the prevalence of comorbid conditions in pediatric patients, their pathogenetic mechanisms, and clinical significance. Particular attention is paid to the relationship between immunological disorders, the state of the intestinal microbiota, and functional indicators of the respiratory system. The study demonstrated that in children with bronchial asthma and concomitant gastrointestinal diseases, the course of the illness is characterized by a higher frequency of exacerbations, significant changes in pulmonary function, reduced levels of fecal elastase-1, and dysbiotic alterations of the intestine. These factors are associated with more severe clinical manifestations, decreased effectiveness of basic therapy, and impaired quality of life. A comprehensive diagnostic approach, including assessment of respiratory function, gastrointestinal examination, analysis of the microbiota, and evaluation of immunological parameters, makes it possible to identify comorbid conditions in a timely manner and to individualize therapy. The findings emphasize the necessity of a multidisciplinary approach in the management of children with bronchial asthma and concomitant gastrointestinal disorders.
| Mualliflar | Ergasheva, Dilsora, Xudoyqulov, Erkin, Tashmatova, Gulnoza, Эргашева, Дилсора, Худойкулов, Эркин, Ташматова, Гулноза, Ergasheva, Dilsora, Xudoyqulov, Erkin, Tashmatova, Gulnoza |
|---|---|
| Jurnal | Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi |
| Nashr sanasi | 2025-12-24 |
| Jild | 4 |
| Son | 6 |
| Betlar | 113-116 |
| Til | Rus |
| DOI | 10.56121/2181-3612-2025-6-113-116 |
DOI: 10.56121/2181-3612-2025-6-113-116 · Maqolaning asl sahifasi
bronchial asthma, children, gastrointestinal tract, microbiota, fecal elastase-1, clinical and functional features, бронхиальная астма, дети, желудочно-кишечный тракт, микробиота, фекальная эластаза-1, клинико-функциональные особенности, bronxial astma, bolalar, oshqozon-ichak trakti, mikrobiota, fekal elastaza-1, kliniko-funktsional xususiyatlar
Most literature devoted to analyzing the course of novel coronavirus infection in pregnant women, women in labor, and newborns has assessed the somatic status and morphofunctional characteristics of children born to…
Relevance. Anemia in preschool children remains one of the major medical and social problems in pediatrics, affecting physical and cognitive development, resistance to infections, and the formation of chronic…
Main The pathogenesis is linked to impaired cortisol synthesis, a deficiency of which, through a feedback loop, stimulates ACTH secretion, leading to adrenal cortex hyperplasia and increased steroidogenesis. Moreover…
Introduction. Hypoxic-ischemic encephalopathy (HIE) in newborns is one of the most severe forms of perinatal central nervous system injury. This condition develops as a result of oxygen deficiency and impaired cerebral…
Respiratory distress syndrome (P22.0; ICD-10) is a condition associated with lung immaturity and surfactant deficiency in neonates born prematurely. Treatment of RDS remains a key component of neonatal intensive care…
Relevance. The COVID-19 pandemic has significantly altered the clinical course of many chronic pathologies. Despite the relatively mild course of infection in most children, in the post-COVID period patients with…
Bronchial asthma and atopic dermatitis occupy a leading place among chronic allergic diseases of childhood. Their prevalence worldwide shows a steady upward trend, which is associated with changes in the ecological…
Relevance. Pneumonia is a polyetiological disease; its risk and severity depend on the infectious agent, age-related and comorbid factors, as well as on socioeconomic and environmental conditions. The etiology of…
Relevance. Respiratory syncytial virus (RSV) infection remains one of the leading causes of acute respiratory diseases in infants and young children, representing a serious medical and socio-economic problem…
Objective To study the clinical and microbiological alterations of the intestinal microbiota in children with bronchial asthma associated with Mycoplasma pneumoniae and Chlamydia pneumoniae infections, and to…
Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar