Clinical and microbiological characteristics of the intestinal microbiota in children with bronchial asthma associated with mycoplasma pneumoniae and chlamydia pneumoniae

Tashmatova, Gulnoza, Xalilova, Zilola, Ташматова, Гульноза, Халилова, Зилола, Tashmatova, Gulnoza, Xalilova, Zilola

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Objective To study the clinical and microbiological alterations of the intestinal microbiota in children with bronchial asthma associated with Mycoplasma pneumoniae and Chlamydia pneumoniae infections, and to determine their correlation with disease severity. Materials and Methods. From 2023 to 2025, 78 children aged 7–15 years with bronchial asthma were observed at the Department of Pediatric Allergology, Tashkent Medical Academy. Patients were distributed according to asthma severity: mild — 41 children, moderate — 23 children, and severe — 14 children. A control group consisted of 42 healthy children. All subjects underwent serological testing (for antibodies to M. pneumoniae and C. pneumoniae), spirometry, and microbiological analysis of intestinal flora. Results and Discussion. Infections caused by Mycoplasma pneumoniae and Chlamydia pneumoniae were found to exacerbate the clinical course of bronchial asthma in children. These infections lead to significant dysbiosis of the intestinal microbiota, characterized by a decrease in beneficial bacteria (Bifidobacterium, Lactobacillus) and an increase in opportunistic microorganisms (Escherichia coli, Clostridium, Bacteroides). The imbalance in the intestinal microbiome correlated with disease severity. In children with severe asthma, the level of beneficial bacteria decreased by 45–55%, while opportunistic flora increased by 30–40% compared to the control group. Additionally, elevated levels of pro-inflammatory cytokines (IL-4, TNF-α) and immunoglobulin E (IgE) were observed, indicating an intensified immune response and persistent airway inflammation. Conclusion. Mycoplasma pneumoniae and Chlamydia pneumoniae infections aggravate the course of bronchial asthma in children and induce intestinal dysbiosis. The reduction of beneficial bacteria and the overgrowth of conditionally pathogenic flora are associated with more severe forms of asthma. Alterations in the intestinal microbiota modulate immune activity by increasing IL-4, TNF-α, and IgE levels, which enhance inflammation and allergic reactivity. Early detection of dysbiosis and the inclusion of probiotic therapy in complex treatment regimens may improve the clinical course of bronchial asthma in children.

Maqola ma’lumotlari
MualliflarTashmatova, Gulnoza, Xalilova, Zilola, Ташматова, Гульноза, Халилова, Зилола, Tashmatova, Gulnoza, Xalilova, Zilola
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-12-24
Jild4
Son6
Betlar83-86
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-6-83-86
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-6-83-86 · Maqolaning asl sahifasi

Kalit so‘zlar

Bronchial asthma, children, Mycoplasma pneumoniae, Chlamydia pneumoniae, intestinal microbiota, dysbiosis, бронхиальная астма, дети, Mycoplasma pneumoniae, Chlamydia pneumoniae, кишечный микробиом, дисбиоз, bronxial astma, bolalar, Mycoplasma pneumoniae, Chlamydia pneumoniae, ichak mikrobiotasi, disbioz

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APATashmatova, Gulnoza, Xalilova, Zilola, Ташматова, Гульноза, Халилова, Зилола, Tashmatova, Gulnoza, & Xalilova, Zilola (2025). CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF THE INTESTINAL MICROBIOTA IN CHILDREN WITH BRONCHIAL ASTHMA ASSOCIATED WITH MYCOPLASMA PNEUMONIAE AND CHLAMYDIA PNEUMONIAE. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 83-86. https://doi.org/10.56121/2181-3612-2025-6-83-86
GOST (OAK)Tashmatova, Gulnoza va b. CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF THE INTESTINAL MICROBIOTA IN CHILDREN WITH BRONCHIAL ASTHMA ASSOCIATED WITH MYCOPLASMA PNEUMONIAE AND CHLAMYDIA PNEUMONIAE // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 6. – P. 83-86. – DOI: 10.56121/2181-3612-2025-6-83-86.
MLATashmatova, Gulnoza, Xalilova, Zilola, Ташматова, Гульноза, Халилова, Зилола, Tashmatova, Gulnoza, and Xalilova, Zilola. “CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF THE INTESTINAL MICROBIOTA IN CHILDREN WITH BRONCHIAL ASTHMA ASSOCIATED WITH MYCOPLASMA PNEUMONIAE AND CHLAMYDIA PNEUMONIAE.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 83-86, 2025. https://doi.org/10.56121/2181-3612-2025-6-83-86
ChicagoTashmatova, Gulnoza, Xalilova, Zilola, Ташматова, Гульноза, Халилова, Зилола, Tashmatova, Gulnoza, and Xalilova, Zilola. “CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF THE INTESTINAL MICROBIOTA IN CHILDREN WITH BRONCHIAL ASTHMA ASSOCIATED WITH MYCOPLASMA PNEUMONIAE AND CHLAMYDIA PNEUMONIAE.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 83-86 (2025). https://doi.org/10.56121/2181-3612-2025-6-83-86
HarvardTashmatova, Gulnoza, Xalilova, Zilola, Ташматова, Гульноза, Халилова, Зилола, Tashmatova, Gulnoza, and Xalilova, Zilola (2025) ‘CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF THE INTESTINAL MICROBIOTA IN CHILDREN WITH BRONCHIAL ASTHMA ASSOCIATED WITH MYCOPLASMA PNEUMONIAE AND CHLAMYDIA PNEUMONIAE’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 83-86. https://doi.org/10.56121/2181-3612-2025-6-83-86
BibTeX
@article{tashmatovagulnoza2025,
  title = {CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF THE INTESTINAL MICROBIOTA IN CHILDREN WITH BRONCHIAL ASTHMA ASSOCIATED WITH MYCOPLASMA PNEUMONIAE AND CHLAMYDIA PNEUMONIAE},
  author = {Tashmatova, Gulnoza and Xalilova, Zilola and Ташматова, Гульноза and Халилова, Зилола and Tashmatova, Gulnoza and Xalilova, Zilola},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {6},
  pages = {83-86},
  doi = {10.56121/2181-3612-2025-6-83-86},
  url = {https://doi.org/10.56121/2181-3612-2025-6-83-86}
}

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