Influence of thyroid hormonal imbalance on the severity of nephrotic syndrome in children

Rakhmanova, Lola, Boltaboeva, Mukaddas, Matkarimova, Shakhodat, Рахманова, Лола, Болтабоева, Мукаддас, Маткаримова, Шаходат, Raxmanova, Lola, Boltaboeva, Mukaddas, Matkarimova, Shakhodat

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Relevance. Nephrotic syndrome (NS) in children is a common kidney disorder often associated with immune and endocrine imbalance. Thyroid hormone changes may affect NS pathogenesis, clinical manifestations, and treatment response. Purpose of the study Evaluation of the effect of thyroid dysfunction on the clinical manifestations of NS in children. Materials and methods of the study. Eighty children (1–18 years) with NS and 30 healthy controls were studied. According to serum TSH, T3, and T4, patients were divided into groups with normal thyroid function, hypothyroidism, and hyperthyroidism. Clinical, biochemical, ultrasound, and immunological parameters were evaluated. Research results. Subclinical hypothyroidism was common in active NS. In hypothyroid patients, edema lasted longer, hypoproteinemia, hypercholesterolemia, and proteinuria were more severe (p<0,05), with frequent relapses and corticosteroid dependence. Conclusion. Thyroid dysfunction increases NS severity. Regular thyroid evaluation and endocrinologist involvement are crucial in pediatric management.

Maqola ma’lumotlari
MualliflarRakhmanova, Lola, Boltaboeva, Mukaddas, Matkarimova, Shakhodat, Рахманова, Лола, Болтабоева, Мукаддас, Маткаримова, Шаходат, Raxmanova, Lola, Boltaboeva, Mukaddas, Matkarimova, Shakhodat
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-12-24
Jild4
Son6
Betlar79-82
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-6-79-82
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-6-79-82 · Maqolaning asl sahifasi

Kalit so‘zlar

nephrotic syndrome, thyroid dysfunction, children, hypothyroidism, proteinuria, нефротический синдром, тиреоидная дисфункция, дети, гипотиреоз, протеинурия, nefrotik sindrom, tireoid disfunktsiya, bolalar, gipotireoz, proteinuriya, giperlipidemiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARakhmanova, Lola, Boltaboeva, Mukaddas, Matkarimova, Shakhodat, Рахманова, Лола, Болтабоева, Мукаддас, Маткаримова, Шаходат, Raxmanova, Lola, Boltaboeva, Mukaddas, & Matkarimova, Shakhodat (2025). INFLUENCE OF THYROID HORMONAL IMBALANCE ON THE SEVERITY OF NEPHROTIC SYNDROME IN CHILDREN. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 79-82. https://doi.org/10.56121/2181-3612-2025-6-79-82
GOST (OAK)Rakhmanova, Lola va b. INFLUENCE OF THYROID HORMONAL IMBALANCE ON THE SEVERITY OF NEPHROTIC SYNDROME IN CHILDREN // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 6. – P. 79-82. – DOI: 10.56121/2181-3612-2025-6-79-82.
MLARakhmanova, Lola, Boltaboeva, Mukaddas, Matkarimova, Shakhodat, Рахманова, Лола, Болтабоева, Мукаддас, Маткаримова, Шаходат, Raxmanova, Lola, Boltaboeva, Mukaddas, and Matkarimova, Shakhodat. “INFLUENCE OF THYROID HORMONAL IMBALANCE ON THE SEVERITY OF NEPHROTIC SYNDROME IN CHILDREN.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 79-82, 2025. https://doi.org/10.56121/2181-3612-2025-6-79-82
ChicagoRakhmanova, Lola, Boltaboeva, Mukaddas, Matkarimova, Shakhodat, Рахманова, Лола, Болтабоева, Мукаддас, Маткаримова, Шаходат, Raxmanova, Lola, Boltaboeva, Mukaddas, and Matkarimova, Shakhodat. “INFLUENCE OF THYROID HORMONAL IMBALANCE ON THE SEVERITY OF NEPHROTIC SYNDROME IN CHILDREN.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 79-82 (2025). https://doi.org/10.56121/2181-3612-2025-6-79-82
HarvardRakhmanova, Lola, Boltaboeva, Mukaddas, Matkarimova, Shakhodat, Рахманова, Лола, Болтабоева, Мукаддас, Маткаримова, Шаходат, Raxmanova, Lola, Boltaboeva, Mukaddas, and Matkarimova, Shakhodat (2025) ‘INFLUENCE OF THYROID HORMONAL IMBALANCE ON THE SEVERITY OF NEPHROTIC SYNDROME IN CHILDREN’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 79-82. https://doi.org/10.56121/2181-3612-2025-6-79-82
BibTeX
@article{rakhmanovalola2025,
  title = {INFLUENCE OF THYROID HORMONAL IMBALANCE ON THE SEVERITY OF NEPHROTIC SYNDROME IN CHILDREN},
  author = {Rakhmanova, Lola and Boltaboeva, Mukaddas and Matkarimova, Shakhodat and Рахманова, Лола and Болтабоева, Мукаддас and Маткаримова, Шаходат and Raxmanova, Lola and Boltaboeva, Mukaddas and Matkarimova, Shakhodat},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {6},
  pages = {79-82},
  doi = {10.56121/2181-3612-2025-6-79-82},
  url = {https://doi.org/10.56121/2181-3612-2025-6-79-82}
}

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