Relevance. Recurrent obstructive bronchitis (ROB) is an inflammatory disease of the bronchi characterized by repeated episodes of inflammation of the mucous and submucosal layers of the bronchial tree, leading to bronchial obstruction due to edema, hypersecretion, and smooth muscle spasm. ROB remains one of the leading causes of pediatric morbidity in preschool-aged children. Objective. To study the clinical features of recurrent obstructive bronchitis (ROBB) in preschoolers and to assess the association between serum 25(OH)D levels and the frequency of exacerbations. Materials and methods. The study included 50 preschool children with ROB. Clinical, laboratory, and instrumental examinations were performed, along with the collection of data on vitamin D intake and environmental factors. Results. Fifty preschool children with recurrent obstructive syndrome were examined. Based on serum vitamin D levels, participants were divided into three groups: Group 1 – children with vitamin D deficiency (n = 15; 30.0%), mean 25(OH)D level 17.6 ± 1.2 ng/mL; Group 2 – children with vitamin D insufficiency (n = 19; 44.0%), mean 24.6 ± 1.2 ng/mL; Group 3 – children with normal vitamin D levels (n = 16; 32.0%), mean 30.6 ± 1.2 ng/mL. The mean age of the participants was 4.2 ± 1.1 years (median — 4.0 years); 28 (56%) were boys and 22 (44%) were girls. A high frequency of exacerbations was observed among children with low vitamin D levels. A statistically significant inverse correlation was found between serum 25(OH)D levels and the number of annual episodes (r = –0.45, p < 0.01). In the group with 25(OH)D < 20 ng/mL, the mean number of exacerbations per year was 5.2 ± 1.3, whereas in those with 25(OH)D ≥ 30 ng/mL it was 3.1 ± 1.1 (p = 0.002). Vitamin D deficiency may serve as a marker of increased risk for obstructive exacerbations in preschool children. It is recommended to include serum 25(OH)D assessment in clinical practice and to correct deficiency when necessary. Summary. Our study demonstrates that preschoolers with recurrent obstructive bronchitis and low 25(OH)D levels have a higher frequency of obstructive episodes, more severe disease course, and increased hospitalization rates. These findings suggest that vitamin D insufficiency may play a role in the pathogenesis of recurrent obstructive airway diseases in children. Larger prospective randomized studies are needed to confirm this hypothesis. In clinical practice, vitamin D assessment should be incorporated into the diagnostic and preventive algorithm for children with severe or recurrent ROB.
| Mualliflar | Kuryazova, Sharofat, Ilkhomova, Khilola, Erkinova, Gulnoza, Курьязова, Шарофат, Илхомова, Хилола, Эркинова, Гулноза, Kuryazova, Sharofat, Ilkhomova, Khilola, Erkinova, Gulnoza |
|---|---|
| Jurnal | Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi |
| Nashr sanasi | 2025-12-24 |
| Jild | 4 |
| Son | 6 |
| Betlar | 48-52 |
| Til | Rus |
| DOI | 10.56121/2181-3612-2025-6-48-52 |
DOI: 10.56121/2181-3612-2025-6-48-52 · Maqolaning asl sahifasi
recurrent obstructive bronchitis, preschool children, vitamin D, 25-hydroxyvitamin D, exacerbations, immunoregulation, рецидивирующий обструктивный бронхит, дошкольники, витамин D, 25-гидроксивитамин D, обострения, иммунорегуляция, qaytalanuvchi obstruktiv bronxit, maktabgacha yosh, vitamin D, 25-gidroksivitamin D, xurujlar, immunoregulyatsiya
Study Objective: To determine the feasibility of predicting the development of multiple organ dysfunction syndrome (MODS) in children with peritonitis based on an analysis of blood coagulation (hemostasis) parameters…
Relevance. Urinary tract infections (UTIs) in adolescent girls are among the most common childhood diseases, second only to respiratory tract infections. Special attention is required for cases with comorbid…
Objective: To determine the prevalence, risk factors, and clinical features of urate nephropathy (UN) in frequently ill children (FIC). Materials and Methods: The study was conducted at the multidisciplinary clinic of…
Introduction. Acute pneumonia remains one of the leading causes of morbidity and mortality in early childhood. According to WHO data, approximately 15–18% of deaths among children under five years of age are due to…
Relevance. In recent decades, there has been an increase in the proportion of atypical pneumonias caused by pathogens such as Mycoplasma pneumoniae, Chlamydophila pneumoniae, less frequently Legionella pneumophila, and…
Relevance. Inflammatory bronchopulmonary diseases in children, such as bronchitis, pneumonia, and bronchiolitis, remain among the most urgent problems in modern pediatrics. Microcirculatory dysfunction plays a central…
Relevance. In recent years, chronic kidney disease (CKD) has become a serious global health problem. Mortality due to CKD continues to rise, and according to forecasts, by 2040 these diseases may rank fifth among all…
Relevance.Exclusive breastfeeding during the first six months of life plays a decisive role in the development of the immune system and healthy growth of children. The aim of the study. To study and compare the…
Relevance. Nephrotic syndrome (NS) in children is a common kidney disorder often associated with immune and endocrine imbalance. Thyroid hormone changes may affect NS pathogenesis, clinical manifestations, and treatment…
Introduction. Preschool-aged children (1–5 years) represent a critical stage for growth and health development. Anemia and obesity remain major public health challenges affecting cognitive and physical outcomes. Early…
Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar