Post-covid changes in clinical and laboratory parameters and their interrelationships in children with bronchial asthma

Khalmatova, Barno, Tashmatova, Gulnoza, Халматова, Барно, Ташматова, Гулноза, Khalmatova, Barno, Tashmatova, Gulnoza

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Relevance. The COVID-19 pandemic has significantly altered the clinical course of many chronic pathologies. Despite the relatively mild course of infection in most children, in the post-COVID period patients with bronchial asthma increasingly present with persistent functional impairments, immune imbalances, and biochemical shifts that can affect disease severity, frequency of exacerbations, and the effectiveness of basic therapy. Objective: to identify the clinical and laboratory features and their correlations in children with bronchial asthma during the post-COVID period. Materials and Methods. To comprehensively study the immune status of children suffering from bronchial asthma (BA) who had previously contracted COVID-19, a clinical and laboratory study was conducted, covering 135 children aged 7 to 15 years. All patients were under observation in pediatric inpatient and outpatient settings. Results and Discussion. A moderate correlation was found between the duration of wheezing and serum potassium (K⁺) levels (r = +0.57), while the relationship with calcium (Ca²⁺) was weak (r = –0.37). The annual frequency of exacerbations correlated negatively with Ca²⁺ (r = –0.42), but showed a strong positive correlation with K⁺ (r = +0.80) and phosphorus (P) (r = +0.71). These findings indicate that clinical manifestations of BA are directly associated with microelements such as potassium and phosphorus, which may aggravate the disease course. Conclusion. The identified changes in microelement levels confirm their importance in the pathogenesis of bronchial asthma, especially in the context of viral infection, and they may be considered as additional markers of disease severity and therapeutic effectiveness.

Maqola ma’lumotlari
MualliflarKhalmatova, Barno, Tashmatova, Gulnoza, Халматова, Барно, Ташматова, Гулноза, Khalmatova, Barno, Tashmatova, Gulnoza
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-12-24
Jild4
Son6
Betlar94-100
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-6-94-100
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-6-94-100 · Maqolaning asl sahifasi

Kalit so‘zlar

bronchial asthma, children, COVID-19, post-COVID period, clinical and laboratory indicators, immune status, correlation analysis, бронхиальная астма, дети, COVID-19, пост-COVID период, клинико-лабораторные показатели, иммунный статус, корреляционный анализ, bronxial astma, bolalar, COVID-19, post-COVID davri, klinik-laboratoriya ko’rsatkichlar, immun holat, korrelyatsion tahlil

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKhalmatova, Barno, Tashmatova, Gulnoza, Халматова, Барно, Ташматова, Гулноза, Khalmatova, Barno, & Tashmatova, Gulnoza (2025). POST-COVID CHANGES IN CLINICAL AND LABORATORY PARAMETERS AND THEIR INTERRELATIONSHIPS IN CHILDREN WITH BRONCHIAL ASTHMA. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 94-100. https://doi.org/10.56121/2181-3612-2025-6-94-100
GOST (OAK)Khalmatova, Barno va b. POST-COVID CHANGES IN CLINICAL AND LABORATORY PARAMETERS AND THEIR INTERRELATIONSHIPS IN CHILDREN WITH BRONCHIAL ASTHMA // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 6. – P. 94-100. – DOI: 10.56121/2181-3612-2025-6-94-100.
MLAKhalmatova, Barno, Tashmatova, Gulnoza, Халматова, Барно, Ташматова, Гулноза, Khalmatova, Barno, and Tashmatova, Gulnoza. “POST-COVID CHANGES IN CLINICAL AND LABORATORY PARAMETERS AND THEIR INTERRELATIONSHIPS IN CHILDREN WITH BRONCHIAL ASTHMA.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 94-100, 2025. https://doi.org/10.56121/2181-3612-2025-6-94-100
ChicagoKhalmatova, Barno, Tashmatova, Gulnoza, Халматова, Барно, Ташматова, Гулноза, Khalmatova, Barno, and Tashmatova, Gulnoza. “POST-COVID CHANGES IN CLINICAL AND LABORATORY PARAMETERS AND THEIR INTERRELATIONSHIPS IN CHILDREN WITH BRONCHIAL ASTHMA.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 94-100 (2025). https://doi.org/10.56121/2181-3612-2025-6-94-100
HarvardKhalmatova, Barno, Tashmatova, Gulnoza, Халматова, Барно, Ташматова, Гулноза, Khalmatova, Barno, and Tashmatova, Gulnoza (2025) ‘POST-COVID CHANGES IN CLINICAL AND LABORATORY PARAMETERS AND THEIR INTERRELATIONSHIPS IN CHILDREN WITH BRONCHIAL ASTHMA’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 94-100. https://doi.org/10.56121/2181-3612-2025-6-94-100
BibTeX
@article{khalmatovabarno2025,
  title = {POST-COVID CHANGES IN CLINICAL AND LABORATORY PARAMETERS AND THEIR INTERRELATIONSHIPS IN CHILDREN WITH BRONCHIAL ASTHMA},
  author = {Khalmatova, Barno and Tashmatova, Gulnoza and Халматова, Барно and Ташматова, Гулноза and Khalmatova, Barno and Tashmatova, Gulnoza},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {6},
  pages = {94-100},
  doi = {10.56121/2181-3612-2025-6-94-100},
  url = {https://doi.org/10.56121/2181-3612-2025-6-94-100}
}

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