Non–ST-segment elevation myocardial infarction (NSTEMI) is one of the most common forms of acute coronary syndromes and represents a leading cause of cardiovascular morbidity and mortality. In recent years, a substantial proportion of patients presenting with a clinical picture of NSTEMI have been found to have no significant coronary artery stenosis on coronary angiography; this condition is currently defined as myocardial infarction with non-obstructive coronary arteries (MINOCA). This review aims to highlight the pathogenetic mechanisms, diagnostic approaches, risk stratification, and principles of personalized management of myocardial infarction without obstructive coronary artery disease. Diagnostic and therapeutic strategies for MINOCA were analyzed based on international clinical guidelines, large registries, and systematic reviews. MINOCA is a heterogeneous syndrome encompassing multiple pathogenic mechanisms, and treatment tailored to the underlying etiology identified through contemporary imaging modalities significantly improves clinical outcomes. Comprehensive diagnostic evaluation and mechanism-oriented, personalized therapy represent the optimal clinical strategy for patients with NSTEMI presenting as MINOCA.
| Mualliflar | Maxmudov, Mamurjon, Tursunov, Xursand, Muhamedova, Barno, Nazarova, Maftuna, Kuryozov, Rasul, Макмудов, Мамуржон, Турсунов, Хурсанд, Мухамедова, Барно, Назарова, Мафтуна, Курёзов, Расул, Maxmudov, Mamurjon, Tursunov, Xursand, Muhamedova, Barno, Nazarova, Maftuna, Kuryozov, Rasul |
|---|---|
| Jurnal | Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi |
| Nashr sanasi | 2025-12-24 |
| Jild | 4 |
| Son | 6 |
| Betlar | 162-171 |
| Til | uz_Latn |
| DOI | 10.56121/2181-3612-2025-6-162-171 |
DOI: 10.56121/2181-3612-2025-6-162-171 · Maqolaning asl sahifasi
MINOCA, NSTEMI, myocardial infarction without coronary stenosis, acute coronary syndrome, high-sensitivity troponin, CMR, OCT, IVUS, MINOCA, NSTEMI, инфаркт миокарда без стеноза, рый коронарный синдром, высокочувствительный тропонин, CMR, OCT, IVUS, MINOCA, NSTEMI, stenozsiz miokard infarkti, o‘tkir koronar sindrom, yuqori sezgir troponin, CMR, OCT, IVUS
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Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar