Chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) are among the leading causes of morbidity and mortality in the world. The high comorbidity burden presents important clinical challenges in exacerbating the issues of diagnosis and treatment due to overlapping symptom profiles, shared risk factors, and interconnected pathophysiological processes. This narrative review summarizes recent evidence on the epidemiology, pathophysiology, diagnostic challenges and therapeutic strategies for these patients. Peer-reviewed studies were identified by conducting a systematic search of PubMed, MEDLINE, and EMBASE from 2016 to 2024. Existing data suggests that COPD occurs in 20–30\% of patients with CHF, and a comparable proportion of moderate-to-severe COPD has left ventricular dysfunction. Coginitive impairment is an independent predictor of adverse clinical outcomes, including higher rates of hospitalization and mortality. Systemic inflammation, oxidative stress, skeletal muscle dysfunction and neurohormonal activation are shared pathways linking these different diseases. Differential diagnosis is limited because of clinical symptom overlap; however, each mentioned biomarker has complementary diagnostic utility in general: natriuretic peptides will identify pulmonary hypertension due to left heart failure, echocardiography can assess underlying structural heart disease and pulmonary function testing helps characterize the underlying pathology. Management should be a personalized and multi-faceted approach focusing on drug safety related to beta-blockers and bronchodilators along with non-pharmacologic strategies such as pulmonary rehabilitation and cardiac rehabilitation. This review underscores the need for joint clinical assessment and supports more prospective studies of this high-risk group.
| Mualliflar | Gadayev, Abdigaffor, Turakulov, Rustam, Nurullayev, Bakhtiyor, Гадаев, A, Туракулов, Р, Нуруллаев, Б, Gadayev, Abdigaffor, Turakulov, Rustam, Nurullayev, Baxtiyor |
|---|---|
| Jurnal | Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi |
| Nashr sanasi | 2026-02-27 |
| Jild | 5 |
| Son | 1 |
| Betlar | 21-31 |
| Til | Ingliz |
| DOI | 10.56121/msu-2026-1-00003 |
DOI: 10.56121/msu-2026-1-00003 · Maqolaning asl sahifasi
COPD, congestive heart failure, cardiopulmonary comorbidity, dyspnea, diagnosis, pharmacotherapy, rehabilitation, ХОБЛ, застойная сердечная недостаточность, кардиопульмональная коморбидность, одышка, диагностика, фармакотерапия, реабилитация, SOKK, konjestiv yurak yetishmovchiligi, kardiopulmonar komorbidlik, disneya, diagnostika, farmakoterapiya, reabilitatsiya
Chronic gastroduodenal diseases (CGD), including peptic ulcers, chronic gastritis, and gastroduodenitis, are common among people living with HIV. One of the major risk factors associated with these conditions is…
Case: A 1-year-old female patient presented for the workup of a cystic abdominal lesion that was first discovered at 6 to 7 months of life. A first CT scan of the abdomen and retroperitoneal space showed a cystic mass…
Cases of gunshot wounds of the extremities are increasing every year in the Republic of Uzbekistan and other countries of the world. The urgency of this problem is justified by the high rates of death, purulent-septic…
The study of the pharmacokinetics of antibiotics on model objects makes it possible to optimize their dosage and method of administration for further clinical practice. Aim. The aim of this study was to compare…
Combined acute traumatic cerebral injury causes direct damage to brain structures and disrupts the work of distant organs, depending on the severity of the traumatic factor. Neuroendocrine disorders are often…
Non–ST-segment elevation myocardial infarction (NSTEMI) is one of the most common forms of acute coronary syndromes and represents a leading cause of cardiovascular morbidity and mortality. In recent years, a…
Aim. To evaluate the organizational structure, logistics, spectrum of surgical interventions, and clinical outcomes of the Department of Minimally Invasive Surgery and Transplantation of the National Children's Medical…
Relevance. At present, there is a growing interest in studying the role of the central and especially the autonomic nervous system in the development and pathogenetic course of hypertension. However, many aspects of…
Aim. Surgical site infection (SSI) remains a major postoperative complication and contributes to prolonged wound care, antibiotic exposure, antimicrobial resistance and healthcare costs. Bacteriophage therapy has…
Background. Community-acquired pneumonia (CAP) in young children remains a leading cause of morbidity and complications, necessitating early detection of clinical, laboratory, and immunological markers of severe…
Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi — barcha maqolalar