Study of the circadian rhythm of catecholamine metabolism and lipid peroxidation processes in young individuals engaged in IT professions

Oybекova, Gulasal, Xujamberdiyev, Mamazoir, Vaxabov, Bahromjon, Ойбекова, Гуласал, Хужамбердиев, Мамазоир, Вахабов, Бахромжон, Oybекova, Gulasal, Xujamberdiyev, Mamazoir, Vaxabov, Bahromjon

Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi · 2025-yil

Annotatsiya

Relevance. At present, there is a growing interest in studying the role of the central and especially the autonomic nervous system in the development and pathogenetic course of hypertension. However, many aspects of this disease remain insufficiently explored. In particular, the available literature lacks comprehensive scientific studies that describe catecholamine metabolism, the activity of the main catecholamine deamination enzyme-monoamine oxidase, the levels of the final deamination product (VMA), and lipid peroxidation products such as MDA. In recent decades, a priority area of scientific research has been the identification of informative and easily accessible laboratory and instrumental markers that enable early detection of hypertension in young individuals. Aim of the study. To investigate the characteristics of sympathoadrenal system dysfunction and lipid peroxidation processes in young individuals engaged in the IT profession. Materials and methods. A total of 90 men aged 25-44 years were examined; the mean age was 33,2±0.93 years. Clinical, instrumental, and specific laboratory methods were used. Results and conclusions. It was found that young individuals actively engaged in the IT profession exhibit disorders in the functional activity of the sympathoadrenal system, manifested by increased excretion of catecholamines (particularly adrenaline and noradrenaline), disruption of the circadian rhythm of catecholamine excretion, reduced activity of monoamine oxidase (MAO) — the key enzyme responsible for catecholamine deamination — increased levels of vanillylmandelic acid, a secondary metabolite of catecholamines, as well as elevated malondialdehyde (MDA), a secondary product of lipid peroxidation.

Maqola ma’lumotlari
MualliflarOybекova, Gulasal, Xujamberdiyev, Mamazoir, Vaxabov, Bahromjon, Ойбекова, Гуласал, Хужамбердиев, Мамазоир, Вахабов, Бахромжон, Oybекova, Gulasal, Xujamberdiyev, Mamazoir, Vaxabov, Bahromjon
JurnalMedical science of Uzbekistan / O'zbekiston tibbiyot ilmi
NashriyotАндижон давлат тиббиёт институти
ISSN2181-3612
Nashr sanasi2025-12-24
Jild4
Son6
Betlar154-161
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-3612-2025-6-154-161
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-3612-2025-6-154-161 · Maqolaning asl sahifasi

Kalit so‘zlar

hypertension, men, IT, catecholamines, adrenaline, noradrenaline, dopamine, monoamine oxidase, circadian rhythm, vanillylmandelic acid, malondialdehyde, гипертоническая болезнь, мужчины, IT, катехоламины, адреналин, норадреналин, дофамин, моноаминоксидаза, циркадный ритм, ванинилминдальная кислота, малоновый диальдегид, gipertoniya kasalligi, erkaklar, IT, katexolaminlar, adrenalin, noradrenalin, dofamin, monoaminooksidaza, sirkad ritm, vanillinmindal kislotasi, malon dialdegid

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAOybекova, Gulasal, Xujamberdiyev, Mamazoir, Vaxabov, Bahromjon, Ойбекова, Гуласал, Хужамбердиев, Мамазоир, Вахабов, Бахромжон, Oybекova, Gulasal, Xujamberdiyev, Mamazoir, & Vaxabov, Bahromjon (2025). STUDY OF THE CIRCADIAN RHYTHM OF CATECHOLAMINE METABOLISM AND LIPID PEROXIDATION PROCESSES IN YOUNG INDIVIDUALS ENGAGED IN IT PROFESSIONS. Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 154-161. https://doi.org/10.56121/2181-3612-2025-6-154-161
GOST (OAK)Oybекova, Gulasal va b. STUDY OF THE CIRCADIAN RHYTHM OF CATECHOLAMINE METABOLISM AND LIPID PEROXIDATION PROCESSES IN YOUNG INDIVIDUALS ENGAGED IN IT PROFESSIONS // Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi. – 2025. – T. 4, № 6. – P. 154-161. – DOI: 10.56121/2181-3612-2025-6-154-161.
MLAOybекova, Gulasal, Xujamberdiyev, Mamazoir, Vaxabov, Bahromjon, Ойбекова, Гуласал, Хужамбердиев, Мамазоир, Вахабов, Бахромжон, Oybекova, Gulasal, Xujamberdiyev, Mamazoir, and Vaxabov, Bahromjon. “STUDY OF THE CIRCADIAN RHYTHM OF CATECHOLAMINE METABOLISM AND LIPID PEROXIDATION PROCESSES IN YOUNG INDIVIDUALS ENGAGED IN IT PROFESSIONS.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 154-161, 2025. https://doi.org/10.56121/2181-3612-2025-6-154-161
ChicagoOybекova, Gulasal, Xujamberdiyev, Mamazoir, Vaxabov, Bahromjon, Ойбекова, Гуласал, Хужамбердиев, Мамазоир, Вахабов, Бахромжон, Oybекova, Gulasal, Xujamberdiyev, Mamazoir, and Vaxabov, Bahromjon. “STUDY OF THE CIRCADIAN RHYTHM OF CATECHOLAMINE METABOLISM AND LIPID PEROXIDATION PROCESSES IN YOUNG INDIVIDUALS ENGAGED IN IT PROFESSIONS.” Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 154-161 (2025). https://doi.org/10.56121/2181-3612-2025-6-154-161
HarvardOybекova, Gulasal, Xujamberdiyev, Mamazoir, Vaxabov, Bahromjon, Ойбекова, Гуласал, Хужамбердиев, Мамазоир, Вахабов, Бахромжон, Oybекova, Gulasal, Xujamberdiyev, Mamazoir, and Vaxabov, Bahromjon (2025) ‘STUDY OF THE CIRCADIAN RHYTHM OF CATECHOLAMINE METABOLISM AND LIPID PEROXIDATION PROCESSES IN YOUNG INDIVIDUALS ENGAGED IN IT PROFESSIONS’, Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi, 4(6), 154-161. https://doi.org/10.56121/2181-3612-2025-6-154-161
BibTeX
@article{oybovagulasal2025,
  title = {STUDY OF THE CIRCADIAN RHYTHM OF CATECHOLAMINE METABOLISM AND LIPID PEROXIDATION PROCESSES IN YOUNG INDIVIDUALS ENGAGED IN IT PROFESSIONS},
  author = {Oybекova, Gulasal and Xujamberdiyev, Mamazoir and Vaxabov, Bahromjon and Ойбекова, Гуласал and Хужамбердиев, Мамазоир and Вахабов, Бахромжон and Oybекova, Gulasal and Xujamberdiyev, Mamazoir and Vaxabov, Bahromjon},
  journal = {Medical science of Uzbekistan / O'zbekiston tibbiyot ilmi},
  year = {2025},
  volume = {4},
  number = {6},
  pages = {154-161},
  doi = {10.56121/2181-3612-2025-6-154-161},
  url = {https://doi.org/10.56121/2181-3612-2025-6-154-161}
}

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