The role of inflammatory markers and innate immunity parameters in predicting the severity of community-acquired pneumonia in children

Abrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, Axrorxonov, Rustamxon, Абриева, Нодира, Шарипов, Алишер, Сафаров, Зафар, Шукуров, Бобир, Ахрорхонов, Рустамхон, Abrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, Axrorxonov, Rustamxon

Халқаро илмий педиатрия журнали · 2025-yil

Annotatsiya

Introduction. Community-acquired pneumonia (CAP) is one of the most common respiratory infections in children and remains a major challenge in contemporary pediatrics. Assessing the risk of severe disease and predicting treatment outcomes in pediatric patients is of practical importance. Immunological biomarkers – including immunoglobulins, cellular subpopulations, and inflammatory indicators – play a key role in the pathogenesis of CAP and help characterize the immune response and disease severity. Objective. To evaluate the diagnostic and prognostic value of inflammatory markers and innate immunity parameters in children with varying severity of community-acquired pneumonia (CAP). Materials and Methods. The study included 80 children aged 1 month to 3 years with a clinically and radiologically confirmed diagnosis of CAP. Patients were divided into two groups based on disease severity: 40 children with mild CAP and 40 with severe CAP. Severity stratification was performed using clinical criteria, including respiratory rate, degree of intoxication, presence of respiratory failure, and oxygen therapy requirement. Plasma levels of procalcitonin and C-reactive protein, along with immunological parameters – CD16+, CD64+, and neutrophil phagocytic activity—were assessed as indicators of inflammation and innate immunity. Results. Significant differences were found between mild and severe CAP groups in leukocyte count, absolute lymphocyte count, procalcitonin and C-reactive protein concentrations, CD64+ expression, and neutrophil phagocytic activity. Elevated leukocytes, procalcitonin, C-reactive protein, and CD64+ expression (p<0.001) were associated with severe disease, while lymphopenia reflected impaired adaptive immunity (p<0.001). Phagocytic activity was also higher in severe cases (p<0.001). CD16+ did not reach statistical significance, though a tendency toward increased levels was observed. The most informative combination of markers included leukocyte count, procalcitonin/CRP, CD64+, phagocytosis, and lymphocyte count. Conclusion. A combined assessment of inflammatory and immunological biomarkers provides high diagnostic value for early risk stratification of severe CAP in children. The most significant predictors were leukocytosis, lymphopenia, elevated procalcitonin, C-reactive protein, and CD64+, as well as enhanced neutrophil phagocytic activity. Incorporating this biomarker panel may improve early identification of patients requiring intensive monitoring and therapy. The role of CD16+ warrants further investigation.

Maqola ma’lumotlari
MualliflarAbrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, Axrorxonov, Rustamxon, Абриева, Нодира, Шарипов, Алишер, Сафаров, Зафар, Шукуров, Бобир, Ахрорхонов, Рустамхон, Abrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, Axrorxonov, Rustamxon
JurnalХалқаро илмий педиатрия журнали
NashriyotАндижон давлат тиббиёт институти; In Science МЧЖ
ISSN2181-2926, 2181-2926
Nashr sanasi2025-12-23
Jild4
Son6
Betlar1160-1164
TilIngliz
Ilmiy sohaTibbiyot
DOI10.56121/2181-2926-2025-4-6-1160-1164
Indeksga qo‘shilgan2026-08-26

DOI: 10.56121/2181-2926-2025-4-6-1160-1164 · Maqolaning asl sahifasi

Kalit so‘zlar

внебольничная пневмония, дети, воспалительные маркеры, врождённый иммунитет, сommunity-acquired pneumonia, children, inflammatory markers, innate immunity, procalcitonin, C-reactive protein, CD64, phagocytosis, kasalxonadan tashqarida orttirilgan pnevmoniya, bolalar, lig‘lanish markerlari, tug‘ma immunitet, prokaltsitonin, C-reaktiv oqsil, CD64, fagotsitoz

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAbrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, Axrorxonov, Rustamxon, Абриева, Нодира, Шарипов, Алишер, Сафаров, Зафар, Шукуров, Бобир, Ахрорхонов, Рустамхон, Abrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, & Axrorxonov, Rustamxon (2025). THE ROLE OF INFLAMMATORY MARKERS AND INNATE IMMUNITY PARAMETERS IN PREDICTING THE SEVERITY OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN. Халқаро илмий педиатрия журнали, 4(6), 1160-1164. https://doi.org/10.56121/2181-2926-2025-4-6-1160-1164
GOST (OAK)Abrieva, Nodira va b. THE ROLE OF INFLAMMATORY MARKERS AND INNATE IMMUNITY PARAMETERS IN PREDICTING THE SEVERITY OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN // Халқаро илмий педиатрия журнали. – 2025. – T. 4, № 6. – P. 1160-1164. – DOI: 10.56121/2181-2926-2025-4-6-1160-1164.
MLAAbrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, Axrorxonov, Rustamxon, Абриева, Нодира, Шарипов, Алишер, Сафаров, Зафар, Шукуров, Бобир, Ахрорхонов, Рустамхон, Abrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, and Axrorxonov, Rustamxon. “THE ROLE OF INFLAMMATORY MARKERS AND INNATE IMMUNITY PARAMETERS IN PREDICTING THE SEVERITY OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN.” Халқаро илмий педиатрия журнали, 4(6), 1160-1164, 2025. https://doi.org/10.56121/2181-2926-2025-4-6-1160-1164
ChicagoAbrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, Axrorxonov, Rustamxon, Абриева, Нодира, Шарипов, Алишер, Сафаров, Зафар, Шукуров, Бобир, Ахрорхонов, Рустамхон, Abrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, and Axrorxonov, Rustamxon. “THE ROLE OF INFLAMMATORY MARKERS AND INNATE IMMUNITY PARAMETERS IN PREDICTING THE SEVERITY OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN.” Халқаро илмий педиатрия журнали, 4(6), 1160-1164 (2025). https://doi.org/10.56121/2181-2926-2025-4-6-1160-1164
HarvardAbrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, Axrorxonov, Rustamxon, Абриева, Нодира, Шарипов, Алишер, Сафаров, Зафар, Шукуров, Бобир, Ахрорхонов, Рустамхон, Abrieva, Nodira, Sharipov, Alisher, Safarov, Zafar, Shukurov, Bobir, and Axrorxonov, Rustamxon (2025) ‘THE ROLE OF INFLAMMATORY MARKERS AND INNATE IMMUNITY PARAMETERS IN PREDICTING THE SEVERITY OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN’, Халқаро илмий педиатрия журнали, 4(6), 1160-1164. https://doi.org/10.56121/2181-2926-2025-4-6-1160-1164
BibTeX
@article{abrievanodira2025,
  title = {THE ROLE OF INFLAMMATORY MARKERS AND INNATE IMMUNITY PARAMETERS IN PREDICTING THE SEVERITY OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN},
  author = {Abrieva, Nodira and Sharipov, Alisher and Safarov, Zafar and Shukurov, Bobir and Axrorxonov, Rustamxon and Абриева, Нодира and Шарипов, Алишер and Сафаров, Зафар and Шукуров, Бобир and Ахрорхонов, Рустамхон and Abrieva, Nodira and Sharipov, Alisher and Safarov, Zafar and Shukurov, Bobir and Axrorxonov, Rustamxon},
  journal = {Халқаро илмий педиатрия журнали},
  year = {2025},
  volume = {4},
  number = {6},
  pages = {1160-1164},
  doi = {10.56121/2181-2926-2025-4-6-1160-1164},
  url = {https://doi.org/10.56121/2181-2926-2025-4-6-1160-1164}
}

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