Infiltrative-purulent forms of laryngitis in children represent one of the most clinically significant and potentially dangerous pathologies of the upper respiratory tract, characterized by a high risk of acute laryngeal stenosis and purulent-inflammatory complications. In the context of an evolving etiological structure of the disease and the growing prevalence of antibiotic resistance, the selection of optimal antibacterial therapy remains a complex and debated issue. This review systematizes current data on the etiology, pathogenesis, and clinical features of infiltrative-purulent laryngitis in children, and outlines the key principles of rational antibiotic prescribing. Special attention is given to the pathogenetic rationale for the use of various antibiotic classes, their pharmacokinetic properties, and their antimicrobial activity spectrum against common pathogens. The review also addresses issues related to increasing microbial resistance, the frequency of clinical prescribing errors, and insufficient patient compliance. A separate section examines the safety of antibacterial therapy in pediatric practice, including the risks of adverse reactions, age-related limitations, and the need for careful monitoring of potential complications. Furthermore, contemporary approaches to combined treatment are discussed, including the use of systemic glucocorticosteroids, anti-inflammatory agents, inhalation therapy, and surgical interventions in complicated cases. The review highlights key directions for improving antibacterial therapy, such as the development of personalized treatment regimens and the expansion of antibiotic resistance control programs.
| Mualliflar | Shamatov, Islom, Шаматов, Ислом, Shamatov, Islom |
|---|---|
| Jurnal | Халқаро илмий педиатрия журнали |
| Nashr sanasi | 2025-12-17 |
| Jild | 4 |
| Son | 6 |
| Betlar | 1153-1159 |
| Til | Rus |
| DOI | 10.56121/2181-2926-2025-4-6-1153-1159 |
DOI: 10.56121/2181-2926-2025-4-6-1153-1159 · Maqolaning asl sahifasi
инфильтративно-гнойный ларингит, дети, антибиотикотерапия, infiltrative-purulent laryngitis, children, antibiotic therapy, infiltrativ-yiringli laringit, bolalar, antibiotikoterapiya
Introduction. Community-acquired pneumonia (CAP) is one of the most common respiratory infections in children and remains a major challenge in contemporary pediatrics. Assessing the risk of severe disease and predicting…
Relevance. Systemic juvenile idiopathic arthritis (sJIA) is a distinct autoinflammatory subtype of juvenile arthritis, characterized by pronounced systemic inflammation and extra-articular manifestations such as fever…
Objective: This study aimed to evaluate the role of neohormones in the development of endocrine infertility in women with overweight and grade I–II obesity, and to determine the relationship between metabolic…
Relevance. Malocclusions, accompanied by overload or underload of individual teeth in a specific region of the jaw, can cause pathological changes in the alveolar process, similar to those observed in periodontal…
Intestinal obstruction in infants and young children is associated with high perioperative morbidity and mortality. Besides surgical factors, anesthesiological management and perioperative intensive care may…
In this article, the authors, referring to their own practice, cases from practice, present information about a rare syndrome in children - Melkersson-Rosenthal. Based on the results of their own clinical observation…
The pathogenesis of pectus excavatum involves not only osteochondral structures but also the soft tissue components of the anterior chest wall, including the sternodiaphragmatic ligament, which plays an important role…
This article presents data from a study of peptide YY-36 in obese children, which plays a key role in the regulation of eating behavior. This peptide is synthesized by L-cells in the distal small and large intestines…
Experimental studies have shown that volatile anesthetics can induce pharmacological preconditioning and reduce the degree of myocardial damage, however, clinical data in pediatric practice remain limited and…
Relevance. Congenital heart defects (CHD) represent the most common group of congenital developmental anomalies in children and remain one of the leading causes of neonatal and infant mortality. According to global…