The Diagnostic and Prognostic Value of Immunological Parameters in Pediatric Pulmonary Tuberculosis

Abdusalomova, Makhliyo, Абдусаломова, Махлиё, Abdusalomova, Mahliyo

Жамият ва инновациялар / Общество и инновации / Society and innovations · 2026-yil

Annotatsiya

Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, with children representing a population at heightened epidemiological risk. This prospective controlled study evaluated the diagnostic and prognostic significance of key immunological parameters in 84 pediatric patients aged 3–14 years: 42 with confirmed active pulmonary tuberculosis and 42 matched healthy controls. T-lymphocyte subpopulations (CD3+, CD4+, CD8+) were assessed by flow cytometry, and serum IFN-γ and IL-4 levels were quantified by ELISA. Active TB was associated with marked suppression of CD4+ T-helper lymphocytes, inversion of the immunoregulatory index (IRI), and profound Th1/Th2 cytokine dysregulation (elevated IL-4 and reduced IFN-γ). These findings substantiate the clinical utility of the CD4+/CD8+ ratio and IFN-γ/IL-4 balance as quantitative biomarkers for disease severity stratification and treatment monitoring in pediatric tuberculosis.

Maqola ma’lumotlari
MualliflarAbdusalomova, Makhliyo, Абдусаломова, Махлиё, Abdusalomova, Mahliyo
JurnalЖамият ва инновациялар / Общество и инновации / Society and innovations
NashriyotIn Science МЧЖ
ISSN2181-1415
Nashr sanasi2026-03-25
Jild7
Son3/S
Betlar42-49
TilIngliz
Ilmiy sohaTibbiyot
DOI10.47689/2181-1415-vol7-iss3/s-pp42-49
Indeksga qo‘shilgan2026-08-26

DOI: 10.47689/2181-1415-vol7-iss3/s-pp42-49 · Maqolaning asl sahifasi

Kalit so‘zlar

туберкулёз, дети, клеточный иммунитет, субпопуляции Т-лимфоцитов, иммунорегуляторный индекс, интерферон-гамма, интерлейкин-4, иммунологические биомаркеры, педиатрический туберкулёз, tuberculosis, children, cellular immunity, T-lymphocyte subpopulations, CD4, CD8 ratio, interferon-gamma, interleukin-4, immunological biomarkers, pediatric tuberculosis, sil, bolalar, hujayraviy immunitet, T-limfotsitlar subpopulyatsiyalari, immunoregulyator indeks, gamma-interferon, interleykin-4, immunologik biomarkerlar, pediatrik sil

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAbdusalomova, Makhliyo, Абдусаломова, Махлиё, & Abdusalomova, Mahliyo (2026). The Diagnostic and Prognostic Value of Immunological Parameters in Pediatric Pulmonary Tuberculosis. Жамият ва инновациялар / Общество и инновации / Society and innovations, 7(3/S), 42-49. https://doi.org/10.47689/2181-1415-vol7-iss3/s-pp42-49
GOST (OAK)Abdusalomova, Makhliyo, Абдусаломова, Махлиё, Abdusalomova, Mahliyo The Diagnostic and Prognostic Value of Immunological Parameters in Pediatric Pulmonary Tuberculosis // Жамият ва инновациялар / Общество и инновации / Society and innovations. – 2026. – T. 7, № 3/S. – P. 42-49. – DOI: 10.47689/2181-1415-vol7-iss3/s-pp42-49.
MLAAbdusalomova, Makhliyo, Абдусаломова, Махлиё, and Abdusalomova, Mahliyo. “The Diagnostic and Prognostic Value of Immunological Parameters in Pediatric Pulmonary Tuberculosis.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 7(3/S), 42-49, 2026. https://doi.org/10.47689/2181-1415-vol7-iss3/s-pp42-49
ChicagoAbdusalomova, Makhliyo, Абдусаломова, Махлиё, and Abdusalomova, Mahliyo. “The Diagnostic and Prognostic Value of Immunological Parameters in Pediatric Pulmonary Tuberculosis.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 7(3/S), 42-49 (2026). https://doi.org/10.47689/2181-1415-vol7-iss3/s-pp42-49
HarvardAbdusalomova, Makhliyo, Абдусаломова, Махлиё, and Abdusalomova, Mahliyo (2026) ‘The Diagnostic and Prognostic Value of Immunological Parameters in Pediatric Pulmonary Tuberculosis’, Жамият ва инновациялар / Общество и инновации / Society and innovations, 7(3/S), 42-49. https://doi.org/10.47689/2181-1415-vol7-iss3/s-pp42-49
BibTeX
@article{abdusalomovamakhliyo2026,
  title = {The Diagnostic and Prognostic Value of Immunological Parameters in Pediatric Pulmonary Tuberculosis},
  author = {Abdusalomova, Makhliyo and Абдусаломова, Махлиё and Abdusalomova, Mahliyo},
  journal = {Жамият ва инновациялар / Общество и инновации / Society and innovations},
  year = {2026},
  volume = {7},
  number = {3/S},
  pages = {42-49},
  doi = {10.47689/2181-1415-vol7-iss3/s-pp42-49},
  url = {https://doi.org/10.47689/2181-1415-vol7-iss3/s-pp42-49}
}

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