The article presents the results of the analysis of the association of CYP3A5 polymorphism (A6986G) with the development of systemic lupus erythematosus (SLE) in children. Forty-five children with SLE and 72 healthy donors were examined. The frequency of the A allele was 88.9% in patients versus 93.75% in the control group, the differences are statistically insignificant (p> 0.05). The G/A genotype was found in 54.5% of patients and 47.2% of healthy people, and G/G in 35.6% of patients and 45.8% in the control, without significant differences (p> 0.05). The potential role of CYP3A5 polymorphism as a pharmacogenetic marker of sensitivity to glucocorticoid therapy in children with SLE is emphasized, which requires further studies with an expanded sample.
| Mualliflar | Faizullaeva, N, Ashurova, D, Ruzibakieva , M, Shermatova, Z, Raufov, A, Файзуллаева, Н, Ашурова, Д, Рузибакиева, М, Шерматова, З, Рауфов, А, Faizullayeva, N, Ashurova, D, Ruzibakiyeva, M, Shermatova, Z, Raufov, А |
|---|---|
| Jurnal | Жамият ва инновациялар / Общество и инновации / Society and innovations |
| Nashr sanasi | 2025-07-15 |
| Jild | 6 |
| Son | 4 |
| Betlar | 141-148 |
| Til | Ingliz |
| DOI | 10.47689/2181-1415-vol6-iss4-pp141-148 |
DOI: 10.47689/2181-1415-vol6-iss4-pp141-148 · Maqolaning asl sahifasi
tizimli qizil yuguruk, bolalar, CYP3A5, A6986G, glyukokortikoidlar, farmakogenetika, genotiplash, immunogenetika, системная красная волчанка, дети, CYP3A5, A6986G, глюкокортикоиды, фармакогенетика, генотипирование, иммуногенетика, systemic lupus erythematosus, children, CYP3A5, A6986G, glucocorticoids, pharmacogenetics, genotyping, immunogenetics
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