Frequency of occurrence of alleles and genotypes of CYP3A5 gene polymorphism (A6986G) in children with systemic lupus erythematosus

Faizullaeva, N, Ashurova, D, Ruzibakieva , M, Shermatova, Z, Raufov, A, Файзуллаева, Н, Ашурова, Д, Рузибакиева, М, Шерматова, З, Рауфов, А, Faizullayeva, N, Ashurova, D, Ruzibakiyeva, M, Shermatova, Z, Raufov, А

Жамият ва инновациялар / Общество и инновации / Society and innovations · 2025-yil

Annotatsiya

The article presents the results of the analysis of the association of CYP3A5 polymorphism (A6986G) with the development of systemic lupus erythematosus (SLE) in children. Forty-five children with SLE and 72 healthy donors were examined. The frequency of the A allele was 88.9% in patients versus 93.75% in the control group, the differences are statistically insignificant (p> 0.05). The G/A genotype was found in 54.5% of patients and 47.2% of healthy people, and G/G in 35.6% of patients and 45.8% in the control, without significant differences (p> 0.05). The potential role of CYP3A5 polymorphism as a pharmacogenetic marker of sensitivity to glucocorticoid therapy in children with SLE is emphasized, which requires further studies with an expanded sample.

Maqola ma’lumotlari
MualliflarFaizullaeva, N, Ashurova, D, Ruzibakieva , M, Shermatova, Z, Raufov, A, Файзуллаева, Н, Ашурова, Д, Рузибакиева, М, Шерматова, З, Рауфов, А, Faizullayeva, N, Ashurova, D, Ruzibakiyeva, M, Shermatova, Z, Raufov, А
JurnalЖамият ва инновациялар / Общество и инновации / Society and innovations
NashriyotIn Science МЧЖ
ISSN2181-1415
Nashr sanasi2025-07-15
Jild6
Son4
Betlar141-148
TilIngliz
Ilmiy sohaTibbiyot
DOI10.47689/2181-1415-vol6-iss4-pp141-148
Indeksga qo‘shilgan2026-08-26

DOI: 10.47689/2181-1415-vol6-iss4-pp141-148 · Maqolaning asl sahifasi

Kalit so‘zlar

tizimli qizil yuguruk, bolalar, CYP3A5, A6986G, glyukokortikoidlar, farmakogenetika, genotiplash, immunogenetika, системная красная волчанка, дети, CYP3A5, A6986G, глюкокортикоиды, фармакогенетика, генотипирование, иммуногенетика, systemic lupus erythematosus, children, CYP3A5, A6986G, glucocorticoids, pharmacogenetics, genotyping, immunogenetics

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAFaizullaeva, N, Ashurova, D, Ruzibakieva , M, Shermatova, Z, Raufov, A, Файзуллаева, Н, Ашурова, Д, Рузибакиева, М, Шерматова, З, Рауфов, А, Faizullayeva, N, Ashurova, D, Ruzibakiyeva, M, Shermatova, Z, & Raufov, А (2025). Frequency of occurrence of alleles and genotypes of CYP3A5 gene polymorphism (A6986G) in children with systemic lupus erythematosus. Жамият ва инновациялар / Общество и инновации / Society and innovations, 6(4), 141-148. https://doi.org/10.47689/2181-1415-vol6-iss4-pp141-148
GOST (OAK)Faizullaeva, N va b. Frequency of occurrence of alleles and genotypes of CYP3A5 gene polymorphism (A6986G) in children with systemic lupus erythematosus // Жамият ва инновациялар / Общество и инновации / Society and innovations. – 2025. – T. 6, № 4. – P. 141-148. – DOI: 10.47689/2181-1415-vol6-iss4-pp141-148.
MLAFaizullaeva, N, Ashurova, D, Ruzibakieva , M, Shermatova, Z, Raufov, A, Файзуллаева, Н, Ашурова, Д, Рузибакиева, М, Шерматова, З, Рауфов, А, Faizullayeva, N, Ashurova, D, Ruzibakiyeva, M, Shermatova, Z, and Raufov, А. “Frequency of occurrence of alleles and genotypes of CYP3A5 gene polymorphism (A6986G) in children with systemic lupus erythematosus.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 6(4), 141-148, 2025. https://doi.org/10.47689/2181-1415-vol6-iss4-pp141-148
ChicagoFaizullaeva, N, Ashurova, D, Ruzibakieva , M, Shermatova, Z, Raufov, A, Файзуллаева, Н, Ашурова, Д, Рузибакиева, М, Шерматова, З, Рауфов, А, Faizullayeva, N, Ashurova, D, Ruzibakiyeva, M, Shermatova, Z, and Raufov, А. “Frequency of occurrence of alleles and genotypes of CYP3A5 gene polymorphism (A6986G) in children with systemic lupus erythematosus.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 6(4), 141-148 (2025). https://doi.org/10.47689/2181-1415-vol6-iss4-pp141-148
HarvardFaizullaeva, N, Ashurova, D, Ruzibakieva , M, Shermatova, Z, Raufov, A, Файзуллаева, Н, Ашурова, Д, Рузибакиева, М, Шерматова, З, Рауфов, А, Faizullayeva, N, Ashurova, D, Ruzibakiyeva, M, Shermatova, Z, and Raufov, А (2025) ‘Frequency of occurrence of alleles and genotypes of CYP3A5 gene polymorphism (A6986G) in children with systemic lupus erythematosus’, Жамият ва инновациялар / Общество и инновации / Society and innovations, 6(4), 141-148. https://doi.org/10.47689/2181-1415-vol6-iss4-pp141-148
BibTeX
@article{faizullaevan2025,
  title = {Frequency of occurrence of alleles and genotypes of CYP3A5 gene polymorphism (A6986G) in children with systemic lupus erythematosus},
  author = {Faizullaeva, N and Ashurova, D and Ruzibakieva , M and Shermatova, Z and Raufov, A and Файзуллаева, Н and Ашурова, Д and Рузибакиева, М and Шерматова, З and Рауфов, А and Faizullayeva, N and Ashurova, D and Ruzibakiyeva, M and Shermatova, Z and Raufov, А},
  journal = {Жамият ва инновациялар / Общество и инновации / Society and innovations},
  year = {2025},
  volume = {6},
  number = {4},
  pages = {141-148},
  doi = {10.47689/2181-1415-vol6-iss4-pp141-148},
  url = {https://doi.org/10.47689/2181-1415-vol6-iss4-pp141-148}
}

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