Aortic Calcification and Pulse Wave Velocity Remain Associated after Adjustment for Kidney Function and Covariates

Jakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Sebastian Nielsen, Martin Bjergskov Thomsen, Michael Maeng, Jesper Møller Jensen, Bjarne Linde Nørgaard, Niels Henrik Buus

PULSE · 2026-yil

Annotatsiya

Introduction: Aortic wall calcification increases arterial stiffness which is often assessed by carotid-femoral pulse wave velocity (cfPWV). However, the impact of kidney function upon the association between calcification of the aortic wall and cfPWV remains unknown. Methods: To examine the association between aortic calcification and cfPWV, we prospectively recruited chronic kidney disease (CKD) patients (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2) and patients with normal renal function, planned for invasive coronary angiography. Participants underwent a non-contrast computed tomography scan of the entire aorta with subsequent Agatston scoring of the aortic wall in addition to a standardized cfPWV measurement and biochemical markers. Results: A total of 144 patients (67.1 ± 10.3 years, 24% female), of whom 110 had CKD (26 stage 3a, 33 stage 3b, 24 stage 4, and 27 stage 5), were included. Agatston score was associated with cfPWV in a univariate regression analysis (p < 0.001). So were age (p < 0.001) and diabetes (p = 0.001), but not gender, smoking status, eGFR, office systolic blood pressure, calcium-phosphate product, C-reactive protein nor vasodilator treatment. Multiple regression analysis including all these factors did not significantly change these associations and relative weight analysis revealed Agatston score to account for 30% of the variation in cfPWV in the model (total r2 = 0.31). Conclusion: In a cohort representing the entire spectrum of kidney function, aortic Agatston score, as well as age and diabetes, were associated with cfPWV after adjustment for other risk factors including eGFR. However, most of the variation in cfPWV remains unexplained by these factors.

Maqola ma’lumotlari
MualliflarJakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Sebastian Nielsen, Martin Bjergskov Thomsen, Michael Maeng, Jesper Møller Jensen, Bjarne Linde Nørgaard, Niels Henrik Buus
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2026-03-18
Jild14
Son1
Betlar43-52
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000551429
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000551429 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAJakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Sebastian Nielsen, Martin Bjergskov Thomsen, Michael Maeng, Jesper Møller Jensen, Bjarne Linde Nørgaard, & Niels Henrik Buus (2026). Aortic Calcification and Pulse Wave Velocity Remain Associated after Adjustment for Kidney Function and Covariates. PULSE, 14(1), 43-52. https://doi.org/10.1159/000551429
GOST (OAK)Jakob Nyvad va b. Aortic Calcification and Pulse Wave Velocity Remain Associated after Adjustment for Kidney Function and Covariates // PULSE. – 2026. – T. 14, № 1. – P. 43-52. – DOI: 10.1159/000551429.
MLAJakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Sebastian Nielsen, Martin Bjergskov Thomsen, Michael Maeng, Jesper Møller Jensen, Bjarne Linde Nørgaard, and Niels Henrik Buus. “Aortic Calcification and Pulse Wave Velocity Remain Associated after Adjustment for Kidney Function and Covariates.” PULSE, 14(1), 43-52, 2026. https://doi.org/10.1159/000551429
ChicagoJakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Sebastian Nielsen, Martin Bjergskov Thomsen, Michael Maeng, Jesper Møller Jensen, Bjarne Linde Nørgaard, and Niels Henrik Buus. “Aortic Calcification and Pulse Wave Velocity Remain Associated after Adjustment for Kidney Function and Covariates.” PULSE, 14(1), 43-52 (2026). https://doi.org/10.1159/000551429
HarvardJakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Sebastian Nielsen, Martin Bjergskov Thomsen, Michael Maeng, Jesper Møller Jensen, Bjarne Linde Nørgaard, and Niels Henrik Buus (2026) ‘Aortic Calcification and Pulse Wave Velocity Remain Associated after Adjustment for Kidney Function and Covariates’, PULSE, 14(1), 43-52. https://doi.org/10.1159/000551429
BibTeX
@article{jakobnyvad2026,
  title = {Aortic Calcification and Pulse Wave Velocity Remain Associated after Adjustment for Kidney Function and Covariates},
  author = {Jakob Nyvad and Kent Lodberg Christensen and Gratien Andersen and Mark Reinhard and Sebastian Nielsen and Martin Bjergskov Thomsen and Michael Maeng and Jesper Møller Jensen and Bjarne Linde Nørgaard and Niels Henrik Buus},
  journal = {PULSE},
  year = {2026},
  volume = {14},
  number = {1},
  pages = {43-52},
  doi = {10.1159/000551429},
  url = {https://doi.org/10.1159/000551429}
}

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