Plasma Metabolomic Signature Predicting Deviation from Healthy Vascular Aging in Two European Cohorts

Dong-Yan Zhang, Dries S. Martens, De-Wei An, Vannina González Marrachelli, Yu-Ling Yu, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Yan Li, Peter Verhamme, Tim S. Nawrot, Daniel Monleon, Josep Redón, Jan A. Staessen

PULSE · 2026-yil

Annotatsiya

Introduction: Biological rather than chronological age (C-age) drives deviation from healthy aging. This study aimed to identify a plasma metabolomic signature indicative of age-related cardiovascular risk (pMTB-age) predicting vascular morbidity and mortality. Methods: = 811 [2001]). Results: The trained model (pMTB-age), relating C-age to the plasma metabolome derived by elastic net regression, included 18 metabolites (six amino acids) and explained from 28.6% to 22.9% of C-age in the discovery and replication data. Feature importance of the retained metabolites derived by SHapley Additive exPlanation showed large interindividual variability in the relation between C-age and pMTB-age. In Flemish and Spanish, cardiovascular risk factors were significantly associated with C-age, pMTB-age, and pMTB-age uncorrelated from C-age (pMTB-age-R). In Flemish (median follow-up 12.3 years) and Spanish (18.8 years), mortality and cardiovascular complications correlated with C-age and pMTB-age. In Flemish, cardiac endpoints (hazard ratio [95% CI] 1.28 [1.00-1.63]) and its components kept significance in relation to pMTB-age-R. The pathway analysis revealed overrepresentation of glycine, serine, and threonine. Conclusions: pMTB-age is a multidimensional biomarker, which identifies individuals with accelerated vascular aging with high precision and combined with the pathway analysis highlights the role of amino acids in vascular disease. Therefore, pMTB-age can guide risk stratification and the personalized and timely prevention and treatment tailored to an individual's unique pMTB-age profile.

Maqola ma’lumotlari
MualliflarDong-Yan Zhang, Dries S. Martens, De-Wei An, Vannina González Marrachelli, Yu-Ling Yu, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Yan Li, Peter Verhamme, Tim S. Nawrot, Daniel Monleon, Josep Redón, Jan A. Staessen
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2026-04-03
Jild14
Son1
Betlar62-77
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000551883
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000551883 · Maqolaning asl sahifasi · PDF

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Psixologiya

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APADong-Yan Zhang, Dries S. Martens, De-Wei An, Vannina González Marrachelli, Yu-Ling Yu, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Yan Li, Peter Verhamme, Tim S. Nawrot, Daniel Monleon, Josep Redón, & Jan A. Staessen (2026). Plasma Metabolomic Signature Predicting Deviation from Healthy Vascular Aging in Two European Cohorts. PULSE, 14(1), 62-77. https://doi.org/10.1159/000551883
GOST (OAK)Dong-Yan Zhang va b. Plasma Metabolomic Signature Predicting Deviation from Healthy Vascular Aging in Two European Cohorts // PULSE. – 2026. – T. 14, № 1. – P. 62-77. – DOI: 10.1159/000551883.
MLADong-Yan Zhang, Dries S. Martens, De-Wei An, Vannina González Marrachelli, Yu-Ling Yu, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Yan Li, Peter Verhamme, Tim S. Nawrot, Daniel Monleon, Josep Redón, and Jan A. Staessen. “Plasma Metabolomic Signature Predicting Deviation from Healthy Vascular Aging in Two European Cohorts.” PULSE, 14(1), 62-77, 2026. https://doi.org/10.1159/000551883
ChicagoDong-Yan Zhang, Dries S. Martens, De-Wei An, Vannina González Marrachelli, Yu-Ling Yu, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Yan Li, Peter Verhamme, Tim S. Nawrot, Daniel Monleon, Josep Redón, and Jan A. Staessen. “Plasma Metabolomic Signature Predicting Deviation from Healthy Vascular Aging in Two European Cohorts.” PULSE, 14(1), 62-77 (2026). https://doi.org/10.1159/000551883
HarvardDong-Yan Zhang, Dries S. Martens, De-Wei An, Vannina González Marrachelli, Yu-Ling Yu, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Yan Li, Peter Verhamme, Tim S. Nawrot, Daniel Monleon, Josep Redón, and Jan A. Staessen (2026) ‘Plasma Metabolomic Signature Predicting Deviation from Healthy Vascular Aging in Two European Cohorts’, PULSE, 14(1), 62-77. https://doi.org/10.1159/000551883
BibTeX
@article{dongyanzhang2026,
  title = {Plasma Metabolomic Signature Predicting Deviation from Healthy Vascular Aging in Two European Cohorts},
  author = {Dong-Yan Zhang and Dries S. Martens and De-Wei An and Vannina González Marrachelli and Yu-Ling Yu and Katarzyna Stolarz-Skrzypek and Marek Rajzer and Yan Li and Peter Verhamme and Tim S. Nawrot and Daniel Monleon and Josep Redón and Jan A. Staessen},
  journal = {PULSE},
  year = {2026},
  volume = {14},
  number = {1},
  pages = {62-77},
  doi = {10.1159/000551883},
  url = {https://doi.org/10.1159/000551883}
}

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