Aging-Related Morphological Remodeling in Cerebral Arteries: A Quantitative Magnetic Resonance Angiography Study

Mi-Yeon Eun, Jong-Un Choi, Ha‑Na Song, Hwan-ho Cho, Wook Kim, Hyung Jun Kim, Jong-Won Chung, Oh-Young Bang, Gyeong-Moon Kim, David S. Liebeskind, Hyunjin Park, Woo-Keun Seo

PULSE · 2026-yil

Annotatsiya

Introduction: Age-related arterial remodeling is a key contributor to cardiovascular disease, but morphological changes in cerebral arteries with aging remain poorly characterized. We aimed to investigate age-related alterations in cerebral arterial morphology using quantitative analysis. Methods: This retrospective observational study analyzed brain magnetic resonance angiography images from 1,168 healthy individuals without cerebrovascular disease. An automated arterial measurement system was used to quantify morphological features, categorized into size metrics (e.g., area), shape metrics (e.g., minimum [min]-maximum [max] diameter ratio), and tortuosity metrics (e.g., curvature). Correlation analyses were performed between age and arterial features, and multivariable regression analyses were conducted to evaluate age-related effects across the entire cerebrovascular tree and individual cerebral arterial segments. Results: < 0.001), reflecting more circular vessel configurations. Curvature did not change significantly with age. Age was independently associated with the global features of cerebral arteries, including mean area (β = 0.285; 95% CI, 0.222-0.347) and mean min-max diameter ratio (β = 0.215; 95% CI, 0.147-0.282). At the level of individual artery analysis, the effect of age on luminal area was more pronounced in internal carotid arteries, whereas age-related changes in the min-max diameter ratio were more evident in medium-sized arteries, including the middle, anterior, and posterior cerebral arteries. Interaction analysis between age and vascular risk factors revealed a significant effect of interaction on arterial shape. Conclusions: Cerebral arteries show distinct age-related morphological alterations, characterized by luminal enlargement and greater circularity. These changes vary with arterial size and location, suggesting differential susceptibility of cerebral arteries to the effects of aging.

Maqola ma’lumotlari
MualliflarMi-Yeon Eun, Jong-Un Choi, Ha‑Na Song, Hwan-ho Cho, Wook Kim, Hyung Jun Kim, Jong-Won Chung, Oh-Young Bang, Gyeong-Moon Kim, David S. Liebeskind, Hyunjin Park, Woo-Keun Seo
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2026-02-03
Jild14
Son1
Betlar20-30
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000550775
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000550775 · Maqolaning asl sahifasi · PDF

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Psixologiya

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APAMi-Yeon Eun, Jong-Un Choi, Ha‑Na Song, Hwan-ho Cho, Wook Kim, Hyung Jun Kim, Jong-Won Chung, Oh-Young Bang, Gyeong-Moon Kim, David S. Liebeskind, Hyunjin Park, & Woo-Keun Seo (2026). Aging-Related Morphological Remodeling in Cerebral Arteries: A Quantitative Magnetic Resonance Angiography Study. PULSE, 14(1), 20-30. https://doi.org/10.1159/000550775
GOST (OAK)Mi-Yeon Eun va b. Aging-Related Morphological Remodeling in Cerebral Arteries: A Quantitative Magnetic Resonance Angiography Study // PULSE. – 2026. – T. 14, № 1. – P. 20-30. – DOI: 10.1159/000550775.
MLAMi-Yeon Eun, Jong-Un Choi, Ha‑Na Song, Hwan-ho Cho, Wook Kim, Hyung Jun Kim, Jong-Won Chung, Oh-Young Bang, Gyeong-Moon Kim, David S. Liebeskind, Hyunjin Park, and Woo-Keun Seo. “Aging-Related Morphological Remodeling in Cerebral Arteries: A Quantitative Magnetic Resonance Angiography Study.” PULSE, 14(1), 20-30, 2026. https://doi.org/10.1159/000550775
ChicagoMi-Yeon Eun, Jong-Un Choi, Ha‑Na Song, Hwan-ho Cho, Wook Kim, Hyung Jun Kim, Jong-Won Chung, Oh-Young Bang, Gyeong-Moon Kim, David S. Liebeskind, Hyunjin Park, and Woo-Keun Seo. “Aging-Related Morphological Remodeling in Cerebral Arteries: A Quantitative Magnetic Resonance Angiography Study.” PULSE, 14(1), 20-30 (2026). https://doi.org/10.1159/000550775
HarvardMi-Yeon Eun, Jong-Un Choi, Ha‑Na Song, Hwan-ho Cho, Wook Kim, Hyung Jun Kim, Jong-Won Chung, Oh-Young Bang, Gyeong-Moon Kim, David S. Liebeskind, Hyunjin Park, and Woo-Keun Seo (2026) ‘Aging-Related Morphological Remodeling in Cerebral Arteries: A Quantitative Magnetic Resonance Angiography Study’, PULSE, 14(1), 20-30. https://doi.org/10.1159/000550775
BibTeX
@article{miyeoneun2026,
  title = {Aging-Related Morphological Remodeling in Cerebral Arteries: A Quantitative Magnetic Resonance Angiography Study},
  author = {Mi-Yeon Eun and Jong-Un Choi and Ha‑Na Song and Hwan-ho Cho and Wook Kim and Hyung Jun Kim and Jong-Won Chung and Oh-Young Bang and Gyeong-Moon Kim and David S. Liebeskind and Hyunjin Park and Woo-Keun Seo},
  journal = {PULSE},
  year = {2026},
  volume = {14},
  number = {1},
  pages = {20-30},
  doi = {10.1159/000550775},
  url = {https://doi.org/10.1159/000550775}
}

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