Associations between Home, Office, and Central Blood Pressure and Microcirculatory Dysfunction in a Middle-Aged Population

Peder af Geijerstam, John Chalmers, Jan Engvall, Hanna Jonasson, Carl Johan Östgren, Sara Bergstrand, Tomas Strömberg, Fredrik H. Nyström, Karin Rådholm

PULSE · 2025-yil

Annotatsiya

Introduction: Hypertension is linked to endothelial dysfunction, but causality and direction is not entirely known. The aim was to study the cross-sectional associations between home, office, and central BP and microcirculatory peak oxygen saturation (OxyP). Methods: In the observational Swedish CArdioPulmonary bioImage Study (SCAPIS) Linköping subsample, office and home BP were measured using an oscillometric device and OxyP was measured in forearm skin after a 5-min occlusion of the brachial artery. A linear regression was fitted to evaluate the mean change in OxyP per SD increase in BP. A logistic regression was fitted to evaluate the associations between BP above the median and OxyP below the median. Results: Of participants, 3,291 were included in the analyses. Per SD increase in systolic home BP, the adjusted mean (95% CI) difference in OxyP was -0.4 (-0.6 to -0.1%). In subgroup analyses, the association remained for women but not men, although the interaction by sex was not statistically significant. Also, in women but not in men, OxyP was lower in those with white coat hypertension vs. sustained normotension, i.e., mean (95% CI) 88.8 (88.2-89.4%) vs. 89.6 (89.3-90.0%), and in those with masked hypertension vs. sustained normotension, i.e., 87.5 (85.9-89.1%) vs. 89.6 (89.3-90.0%). Conclusion: Home BP, which better predicts cardiovascular disease than office BP, was inversely associated with OxyP. This correlation remained in subgroup analyses of women but not men, suggesting possible sex-dependent microcirculatory dysfunction or that masked hypertension could be a more important cardiovascular risk marker in women, despite its higher prevalence in men.

Maqola ma’lumotlari
MualliflarPeder af Geijerstam, John Chalmers, Jan Engvall, Hanna Jonasson, Carl Johan Östgren, Sara Bergstrand, Tomas Strömberg, Fredrik H. Nyström, Karin Rådholm
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2025-11-25
Jild14
Son1
Betlar1-11
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000549752
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000549752 · Maqolaning asl sahifasi · PDF

Ilmiy soha

Psixologiya

Iqtibos keltirish

APAPeder af Geijerstam, John Chalmers, Jan Engvall, Hanna Jonasson, Carl Johan Östgren, Sara Bergstrand, Tomas Strömberg, Fredrik H. Nyström, & Karin Rådholm (2025). Associations between Home, Office, and Central Blood Pressure and Microcirculatory Dysfunction in a Middle-Aged Population. PULSE, 14(1), 1-11. https://doi.org/10.1159/000549752
GOST (OAK)Peder af Geijerstam va b. Associations between Home, Office, and Central Blood Pressure and Microcirculatory Dysfunction in a Middle-Aged Population // PULSE. – 2025. – T. 14, № 1. – P. 1-11. – DOI: 10.1159/000549752.
MLAPeder af Geijerstam, John Chalmers, Jan Engvall, Hanna Jonasson, Carl Johan Östgren, Sara Bergstrand, Tomas Strömberg, Fredrik H. Nyström, and Karin Rådholm. “Associations between Home, Office, and Central Blood Pressure and Microcirculatory Dysfunction in a Middle-Aged Population.” PULSE, 14(1), 1-11, 2025. https://doi.org/10.1159/000549752
ChicagoPeder af Geijerstam, John Chalmers, Jan Engvall, Hanna Jonasson, Carl Johan Östgren, Sara Bergstrand, Tomas Strömberg, Fredrik H. Nyström, and Karin Rådholm. “Associations between Home, Office, and Central Blood Pressure and Microcirculatory Dysfunction in a Middle-Aged Population.” PULSE, 14(1), 1-11 (2025). https://doi.org/10.1159/000549752
HarvardPeder af Geijerstam, John Chalmers, Jan Engvall, Hanna Jonasson, Carl Johan Östgren, Sara Bergstrand, Tomas Strömberg, Fredrik H. Nyström, and Karin Rådholm (2025) ‘Associations between Home, Office, and Central Blood Pressure and Microcirculatory Dysfunction in a Middle-Aged Population’, PULSE, 14(1), 1-11. https://doi.org/10.1159/000549752
BibTeX
@article{pederafgeijerstam2025,
  title = {Associations between Home, Office, and Central Blood Pressure and Microcirculatory Dysfunction in a Middle-Aged Population},
  author = {Peder af Geijerstam and John Chalmers and Jan Engvall and Hanna Jonasson and Carl Johan Östgren and Sara Bergstrand and Tomas Strömberg and Fredrik H. Nyström and Karin Rådholm},
  journal = {PULSE},
  year = {2025},
  volume = {14},
  number = {1},
  pages = {1-11},
  doi = {10.1159/000549752},
  url = {https://doi.org/10.1159/000549752}
}

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