Comparison between Triglyceride Glucose Index and Homeostasis Model Assessment of Insulin Resistance in Their Associations with Vascular Dysfunction: Danyang Study

Junya Liang, Tianna Zhou, Xinyue Wang, Weina Guo, Zhicong Pi, Ziwen Zheng, Xiwu Yan, Yun Gao, Mulian Hua, Siqi Zhang, Ji Soo Song, Ming Liu

PULSE · 2025-yil

Annotatsiya

Introduction: While insulin resistance (IR) is an established risk factor for cardiovascular disease, vascular dysfunction represents a critical early pathological link. Although prior studies support the association between IR and vascular dysfunction, it remains unknown whether IR assessed by homeostasis model assessment of IR (HOMA-IR) or the triglyceride-glucose index (TyG index) is more closely related to specific markers of vascular dysfunction. Methods: A total of 2,278 participants (59.3% women; average age, 56.7 ± 11.0 years) were recruited in this study. The HOMA-IR and TyG index was calculated using (fasting insulin [μIU/mL] × fasting glucose [mmol/L]/22.5) and ln (fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2), respectively. Vascular measurements included brachial-ankle pulse wave velocity (baPWV), cardio-ankle vascular index (CAVI), and urinary albumin-to-creatinine ratio (UACR), representing macro- and microvascular dysfunction, respectively. Results: Irrespective of the assessment methods of IR, both the TyG index and HOMA-IR were all significantly associated with the vascular indices before (p < 0.001) and after full adjustment (p ≤ 0.041). The standardized regression coefficients of the vascular dysfunction with the TyG index were comparable to those with the HOMA-IR after adjustment for various confounders (0.07–15.8 versus 0.05–18.2; Pcompare ≥ 0.108). In multivariable logistic regression analysis, the TyG index was significantly associated with higher risk of arterial stiffness (odds ratio [OR] = 1.37 and 1.26 for abnormal baPWV and CAVI, respectively; p ≤ 0.035), while the HOMA-IR was tightly associated with higher risk of abnormal CAVI (OR = 1.54; p < 0.001) and albuminuria (OR = 1.40; p = 0.006). Further subgroup analyses showed that a more significant association between the TyG index and the prevalence of increased arterial stiffness was observed in women and nondiabetic participants, and participants without chronic kidney disease (CKD) (p ≤ 0.025), while a more significant association between the HOMA-IR and the prevalence of abnormal CAVI and albuminuria was detected in younger individuals, females, normotensive, or normoglycemic subjects (p ≤ 0.035). Conclusion: The TyG index demonstrated a stronger association with arterial stiffness (baPWV) than HOMA-IR, whereas the HOMA-IR showed a more pronounced association with albuminuria, especially in women.

Maqola ma’lumotlari
MualliflarJunya Liang, Tianna Zhou, Xinyue Wang, Weina Guo, Zhicong Pi, Ziwen Zheng, Xiwu Yan, Yun Gao, Mulian Hua, Siqi Zhang, Ji Soo Song, Ming Liu
JurnalPULSE
Nashr sanasi2025-10-07
Jild13
Son1
Betlar166-176
Tilen
DOI10.1159/000548848

DOI: 10.1159/000548848 · Maqolaning asl sahifasi · PDF

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