Indices of Arterial Stiffness and the Alzheimer’s Disease Biomarker, p-tau217, in Non-Demented Midlife Women

Benecia Wan Qing Thia, Darren Yuen Zhang Tan, Beverly Wen Xin Wong, Liang Shen, Lingli Gong, Lieng‐Hsi Ling, Christopher Li-Hsian Chen, Eu‐Leong Yong

PULSE · 2026-yil

Annotatsiya

Introduction: The association between indices of arterial stiffness and/or pressure wave reflection with Alzheimer disease amyloid-β accumulation and tau pathology in the brain is unclear. Deficiency of estrogen post-menopause may be an important contributor to changes in these indices to affect Alzheimer’s disease progression. We aimed to assess the associations between indices of arterial stiffness and/or pressure wave reflection and the Alzheimer’s disease blood biomarker, p-tau217, in midlife women without dementia. Methods: This cross-sectional analysis of participants from the Integrated Women’s Health Program (IWHP) enrolled community-dwelling midlife women without dementia attending routine health screening at the National University Hospital in Singapore. Fasted blood p-tau217 was measured using the Simoa® ALZpath p-tau217 Advantage PLUS (Quanterix, MA, USA). Aortic augmentation index (AIx) and reflection index (RI) were obtained from peripheral arterial pressure waveforms and cardio-ankle vascular index (CAVI) measured using pressure cuffs on the extremities and a phonocardiogram. Multivariable linear regression was used to examine the independent associations between indices of arterial stiffness and serum levels of p-tau217. Results: Among 871 participants (mean age: 62.80 ± 6.02 years), every SD increase in AIx and RI scores was both associated with 0.010 pg/mL (95% CI: 0.003–0.017, p = 0.004) higher blood p-tau217 levels after adjustment for age, employment status, BMI, mild cognitive impairment, hypertension, cholesterol-HDL ratio, renal function, and ApoE4 carrier status. With natural logarithmic transformed p-tau217, RI remained significantly associated with ln(p-tau217), β = 0.026 (0.007, 0.045), p = 0.007, after covariate adjustment. For AIx, the association was attenuated but remained directionally consistent. Trends for the association between CAVI and blood p-tau217 level were not statistically significant after adjustment for covariates. Conclusion: Increases in indices of arterial stiffness and pressure wave reflection were associated with higher blood p-tau217 levels in community-dwelling midlife women without dementia. These indices may be markers of risk for tau-related pathologies in the brain.

Maqola ma’lumotlari
MualliflarBenecia Wan Qing Thia, Darren Yuen Zhang Tan, Beverly Wen Xin Wong, Liang Shen, Lingli Gong, Lieng‐Hsi Ling, Christopher Li-Hsian Chen, Eu‐Leong Yong
JurnalPULSE
NashriyotPROFI университетининг
ISSN2074-1855, 2235-8668
Nashr sanasi2026-05-04
Jild14
Son1
Betlar78-92
TilIngliz
Ilmiy sohaPsixologiya
DOI10.1159/000552328
Indeksga qo‘shilgan2026-09-02

DOI: 10.1159/000552328 · Maqolaning asl sahifasi

Ilmiy soha

Psixologiya

Iqtibos keltirish

APABenecia Wan Qing Thia, Darren Yuen Zhang Tan, Beverly Wen Xin Wong, Liang Shen, Lingli Gong, Lieng‐Hsi Ling, Christopher Li-Hsian Chen, & Eu‐Leong Yong (2026). Indices of Arterial Stiffness and the Alzheimer’s Disease Biomarker, p-tau217, in Non-Demented Midlife Women. PULSE, 14(1), 78-92. https://doi.org/10.1159/000552328
GOST (OAK)Benecia Wan Qing Thia va b. Indices of Arterial Stiffness and the Alzheimer’s Disease Biomarker, p-tau217, in Non-Demented Midlife Women // PULSE. – 2026. – T. 14, № 1. – P. 78-92. – DOI: 10.1159/000552328.
MLABenecia Wan Qing Thia, Darren Yuen Zhang Tan, Beverly Wen Xin Wong, Liang Shen, Lingli Gong, Lieng‐Hsi Ling, Christopher Li-Hsian Chen, and Eu‐Leong Yong. “Indices of Arterial Stiffness and the Alzheimer’s Disease Biomarker, p-tau217, in Non-Demented Midlife Women.” PULSE, 14(1), 78-92, 2026. https://doi.org/10.1159/000552328
ChicagoBenecia Wan Qing Thia, Darren Yuen Zhang Tan, Beverly Wen Xin Wong, Liang Shen, Lingli Gong, Lieng‐Hsi Ling, Christopher Li-Hsian Chen, and Eu‐Leong Yong. “Indices of Arterial Stiffness and the Alzheimer’s Disease Biomarker, p-tau217, in Non-Demented Midlife Women.” PULSE, 14(1), 78-92 (2026). https://doi.org/10.1159/000552328
HarvardBenecia Wan Qing Thia, Darren Yuen Zhang Tan, Beverly Wen Xin Wong, Liang Shen, Lingli Gong, Lieng‐Hsi Ling, Christopher Li-Hsian Chen, and Eu‐Leong Yong (2026) ‘Indices of Arterial Stiffness and the Alzheimer’s Disease Biomarker, p-tau217, in Non-Demented Midlife Women’, PULSE, 14(1), 78-92. https://doi.org/10.1159/000552328
BibTeX
@article{beneciawanqingthia2026,
  title = {Indices of Arterial Stiffness and the Alzheimer’s Disease Biomarker, p-tau217, in Non-Demented Midlife Women},
  author = {Benecia Wan Qing Thia and Darren Yuen Zhang Tan and Beverly Wen Xin Wong and Liang Shen and Lingli Gong and Lieng‐Hsi Ling and Christopher Li-Hsian Chen and Eu‐Leong Yong},
  journal = {PULSE},
  year = {2026},
  volume = {14},
  number = {1},
  pages = {78-92},
  doi = {10.1159/000552328},
  url = {https://doi.org/10.1159/000552328}
}

Boshqa maqola uchun iqtibos tayyorlash

PULSE jurnalidan boshqa maqolalar

PULSE — barcha maqolalar · 2026-yil arxivi

Psixologiya sohasidagi boshqa maqolalar

Psixologiya sohasidagi OAK jurnallari