The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index

Юсупалиева , Д, Алиева, Р, Ахмедова , Ш, Шек , А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova , Shoxista, Shek , Aleksandr, Yusupaliyeva, Dilnora, Aliyeva , Rano, Akhmedova , Shokhista, Shek , Aleksandr

O‘zbekiston кardiologiyasi · 2025-yil

Annotatsiya

In recent years, researchers have focused on the role of various adipose tissue depots in the development of coronary artery disease (CAD), extending beyond traditional obesity assessments based on body mass index (BMI). Visceral adipose tissue, epicardial fat, fatty liver disease (currently termed metabolic dysfunction-associated steatotic liver disease), and perivascular adipose tissue actively participate in CAD pathogenesis through mechanisms of systemic inflammation, oxidative stress, endothelial dysfunction, and atherosclerosis. Visceral fat, characterized by high metabolic activity, secretes proinflammatory cytokines that promote insulin resistance and atherosclerosis. Epicardial fat surrounding the coronary arteries exerts local effects by releasing adipokines that may accelerate the progression of atherosclerotic plaques. Fatty liver disease is associated with dyslipidemia and enhanced systemic inflammation, increasing cardiovascular risk. Perivascular adipose tissue regulates vascular tone and inflammation, and its dysfunction contributes to arterial stiffness and hypertension. The relevance of studying these adipose depots lies in the need to identify new biomarkers and targets for personalized prevention and treatment of CAD. Traditional obesity assessment methods such as BMI, fail to reflect adipose tissue distribution and metabolic activity, underscoring the importance of more detailed investigation into the role of various fat depots in cardiovascular pathology.

Maqola ma’lumotlari
MualliflarЮсупалиева , Д, Алиева, Р, Ахмедова , Ш, Шек , А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova , Shoxista, Shek , Aleksandr, Yusupaliyeva, Dilnora, Aliyeva , Rano, Akhmedova , Shokhista, Shek , Aleksandr
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2025-09-30
Jild2
Son3
Betlar248-263
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2025-2-56
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2025-2-56 · Maqolaning asl sahifasi

Kalit so‘zlar

ишемическая болезнь сердца, локальные жировые депо, ожирение, висцеральное ожирение, эпикардиальная жировая ткань, ассоциированная с метаболической дисфункцией стеатозная болезнь печени, периваскулярная жировая ткань, coronary artery disease, local adipose depots, obesity, visceral obesity, epicardial adipose tissue, metabolic dysfunction-associated steatotic liver disease, perivascular adipose tissue, ishemik yurak kasalligi, lokal yog‘ to‘planmalari, semirish, visseral semirish, yurak atrofi (epikardial) yog‘ to‘qimasi, metabolik disfunktsiya bilan bog‘liq steatoz kasalligi, tomir atrofi yog‘ to‘qimasi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAЮсупалиева , Д, Алиева, Р, Ахмедова , Ш, Шек , А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova , Shoxista, Shek , Aleksandr, Yusupaliyeva, Dilnora, Aliyeva , Rano, Akhmedova , Shokhista, & Shek , Aleksandr (2025). The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index. O‘zbekiston кardiologiyasi, 2(3), 248-263. https://doi.org/10.70626/cardiouz-2025-2-56
GOST (OAK)Юсупалиева , Д va b. The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index // O‘zbekiston кardiologiyasi. – 2025. – T. 2, № 3. – P. 248-263. – DOI: 10.70626/cardiouz-2025-2-56.
MLAЮсупалиева , Д, Алиева, Р, Ахмедова , Ш, Шек , А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova , Shoxista, Shek , Aleksandr, Yusupaliyeva, Dilnora, Aliyeva , Rano, Akhmedova , Shokhista, and Shek , Aleksandr. “The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index.” O‘zbekiston кardiologiyasi, 2(3), 248-263, 2025. https://doi.org/10.70626/cardiouz-2025-2-56
ChicagoЮсупалиева , Д, Алиева, Р, Ахмедова , Ш, Шек , А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova , Shoxista, Shek , Aleksandr, Yusupaliyeva, Dilnora, Aliyeva , Rano, Akhmedova , Shokhista, and Shek , Aleksandr. “The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index.” O‘zbekiston кardiologiyasi, 2(3), 248-263 (2025). https://doi.org/10.70626/cardiouz-2025-2-56
HarvardЮсупалиева , Д, Алиева, Р, Ахмедова , Ш, Шек , А, Yusupaliyeva, Dilnora, Aliyeva, Rano, Axmedova , Shoxista, Shek , Aleksandr, Yusupaliyeva, Dilnora, Aliyeva , Rano, Akhmedova , Shokhista, and Shek , Aleksandr (2025) ‘The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index’, O‘zbekiston кardiologiyasi, 2(3), 248-263. https://doi.org/10.70626/cardiouz-2025-2-56
BibTeX
@article{article2025,
  title = {The Role of Adipose Tissue Depots in the Pathogenesis of Coronary Artery Disease: Beyond Body Mass Index},
  author = {Юсупалиева , Д and Алиева, Р and Ахмедова , Ш and Шек , А and Yusupaliyeva, Dilnora and Aliyeva, Rano and Axmedova , Shoxista and Shek , Aleksandr and Yusupaliyeva, Dilnora and Aliyeva , Rano and Akhmedova , Shokhista and Shek , Aleksandr},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2025},
  volume = {2},
  number = {3},
  pages = {248-263},
  doi = {10.70626/cardiouz-2025-2-56},
  url = {https://doi.org/10.70626/cardiouz-2025-2-56}
}

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