The role of scavenger receptor CD36 in atherogenesis: molecular mechanisms and therapeutic perspectives

Yusupalieva, Dilnora, Alieva, Rano, Мусабаева, Ширин, Nizamov, Ulugbek, Akhmedova, Shoxista, Shek, Aleksandr, Юсупалиева, Дилнора, Алиева, Рано, Мусабаева, Ширин, Низамов, Улугбек, Ахмедова, Шохиста, Шек, Александр, Aliyeva, Rano, Musabayeva, Shirin, Nizamov, Ulugbek, Axmedova, Shoxista, Shek, Aleksandr

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

Scavenger receptor class B type 2 (CD36) is a multiligand transmembrane glycoprotein that combines the functions of a long-chain fatty acid transporter, an oxidised low-density lipoprotein receptor, a pattern-recognition receptor and an intracellular signalling platform. This review summarises current data on CD36 structure, including ectodomain crystallography, and on its role in atherogenesis: modified lipoprotein uptake, foam cell formation, activation of the CD36–TLR4/TLR6–NF-κB and CD36–TLR2 axes and of the NLRP3 inflammasome, mitochondrial oxidative stress, impaired efferocytosis and necrotic core formation. The evidence linking CD36 to coronary artery disease is appraised critically: global and cell-specific knockout models, including inducible deletion of the receptor in macrophages and endothelium, receptor expression in human plaques and monocytes, conflicting soluble CD36 data, genetic association studies, and the paradoxical phenotype of inherited CD36 deficiency. Selective peptide and azapeptide ligands, antisense oligonucleotides, targeting of post-translational modifications, and plaque-directed nanocarriers are discussed. CD36 remains one of the best-argued candidate targets for residual inflammatory risk in atherosclerosis, provided that the receptor is modulated cell-selectively rather than suppressed systemically.

Maqola ma’lumotlari
MualliflarYusupalieva, Dilnora, Alieva, Rano, Мусабаева, Ширин, Nizamov, Ulugbek, Akhmedova, Shoxista, Shek, Aleksandr, Юсупалиева, Дилнора, Алиева, Рано, Мусабаева, Ширин, Низамов, Улугбек, Ахмедова, Шохиста, Шек, Александр, Aliyeva, Rano, Musabayeva, Shirin, Nizamov, Ulugbek, Axmedova, Shoxista, Shek, Aleksandr
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-09-02
Jild3
Son2
Betlar97-110
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00092
Indeksga qo‘shilgan2026-10-21

DOI: 10.70626/cardiouz-2026-3-00092 · Maqolaning asl sahifasi

Kalit so‘zlar

The role of scavenger receptor CD36 in atherogenesis, molecular mechanisms and therapeutic perspectives, CD36 антигены, скэвенджер-рецепторы класса, атеросклероз, ишемическая болезнь сердца, пенистые клетки, инфламмасомы, молекулярная таргетная терапия, Aterogenezda CD36 skavenjer-retseptorining o‘rni, molekulyar mexanizmlar va terapevtik istiqbollar

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Iqtibos keltirish

APAYusupalieva, Dilnora, Alieva, Rano, Мусабаева, Ширин, Nizamov, Ulugbek, Akhmedova, Shoxista, Shek, Aleksandr, Юсупалиева, Дилнора, Алиева, Рано, Мусабаева, Ширин, Низамов, Улугбек, Ахмедова, Шохиста, Шек, Александр, Aliyeva, Rano, Musabayeva, Shirin, Nizamov, Ulugbek, Axmedova, Shoxista, & Shek, Aleksandr (2026). The role of scavenger receptor CD36 in atherogenesis: molecular mechanisms and therapeutic perspectives. O‘zbekiston кardiologiyasi, 3(2), 97-110. https://doi.org/10.70626/cardiouz-2026-3-00092
GOST (OAK)Yusupalieva, Dilnora va b. The role of scavenger receptor CD36 in atherogenesis: molecular mechanisms and therapeutic perspectives // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 2. – P. 97-110. – DOI: 10.70626/cardiouz-2026-3-00092.
MLAYusupalieva, Dilnora, Alieva, Rano, Мусабаева, Ширин, Nizamov, Ulugbek, Akhmedova, Shoxista, Shek, Aleksandr, Юсупалиева, Дилнора, Алиева, Рано, Мусабаева, Ширин, Низамов, Улугбек, Ахмедова, Шохиста, Шек, Александр, Aliyeva, Rano, Musabayeva, Shirin, Nizamov, Ulugbek, Axmedova, Shoxista, and Shek, Aleksandr. “The role of scavenger receptor CD36 in atherogenesis: molecular mechanisms and therapeutic perspectives.” O‘zbekiston кardiologiyasi, 3(2), 97-110, 2026. https://doi.org/10.70626/cardiouz-2026-3-00092
ChicagoYusupalieva, Dilnora, Alieva, Rano, Мусабаева, Ширин, Nizamov, Ulugbek, Akhmedova, Shoxista, Shek, Aleksandr, Юсупалиева, Дилнора, Алиева, Рано, Мусабаева, Ширин, Низамов, Улугбек, Ахмедова, Шохиста, Шек, Александр, Aliyeva, Rano, Musabayeva, Shirin, Nizamov, Ulugbek, Axmedova, Shoxista, and Shek, Aleksandr. “The role of scavenger receptor CD36 in atherogenesis: molecular mechanisms and therapeutic perspectives.” O‘zbekiston кardiologiyasi, 3(2), 97-110 (2026). https://doi.org/10.70626/cardiouz-2026-3-00092
HarvardYusupalieva, Dilnora, Alieva, Rano, Мусабаева, Ширин, Nizamov, Ulugbek, Akhmedova, Shoxista, Shek, Aleksandr, Юсупалиева, Дилнора, Алиева, Рано, Мусабаева, Ширин, Низамов, Улугбек, Ахмедова, Шохиста, Шек, Александр, Aliyeva, Rano, Musabayeva, Shirin, Nizamov, Ulugbek, Axmedova, Shoxista, and Shek, Aleksandr (2026) ‘The role of scavenger receptor CD36 in atherogenesis: molecular mechanisms and therapeutic perspectives’, O‘zbekiston кardiologiyasi, 3(2), 97-110. https://doi.org/10.70626/cardiouz-2026-3-00092
BibTeX
@article{yusupalievadilnora2026,
  title = {The role of scavenger receptor CD36 in atherogenesis: molecular mechanisms and therapeutic perspectives},
  author = {Yusupalieva, Dilnora and Alieva, Rano and Мусабаева, Ширин and Nizamov, Ulugbek and Akhmedova, Shoxista and Shek, Aleksandr and Юсупалиева, Дилнора and Алиева, Рано and Мусабаева, Ширин and Низамов, Улугбек and Ахмедова, Шохиста and Шек, Александр and Aliyeva, Rano and Musabayeva, Shirin and Nizamov, Ulugbek and Axmedova, Shoxista and Shek, Aleksandr},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {2},
  pages = {97-110},
  doi = {10.70626/cardiouz-2026-3-00092},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00092}
}

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