The effect of fixed combination therapy with telmisartan/ amlodipine on cardiometabolic risks in patients with arterial hypertension

Atoeva, Munisa, Abdullaeva, Guzal, Khamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Khafiza, Mansurova, Vasila, Атоева, М, Абдуллаева, Г, Хамидуллаева, Г, Бекметова, С, Юсупова, Х, Мансурова, В, Atoeva, Munisa, Abdullaeva, Guzal, Xamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Xafiza, Mansurova, Vasila

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

Aim. To evaluate the antihypertensive efficacy, effects on cardiometabolic risk factors, regression of target organ damage, and safety of 6-month fixed-combination therapy with telmisartan/amlodipine in patients with arterial hypertension (AH).Materials and Methods. The study enrolled 52 patients aged 18–65 years (mean age 51.90±13.84 years) with grade I–II AH according to the ESH 2023 classification. All patients received a fixed combination of telmisartan/amlodipine Assessment was performed at baseline and after 6 months, including office blood pressure measurement, echocardiography, applanation tonometry, duplex scanning of the carotid arteries, and evaluation of glucose, lipids, uric acid, hepatic transaminases, creatinine with calculation of glomerular filtration rate (GFR), and microalbuminuria (MAU) in morning urine.Results. After 6 months of fixed-combination telmisartan/amlodipine therapy, systolic blood pressure (SBP) decreased by 19.54% and diastolic blood pressure (DBP) by 16.67% (p<0.001). Significant regression of left ventricular hypertrophy (LVH) was observed, as indicated by a 7.6% reduction in left ventricular mass index (LVMI) (p<0.001). Pulse wave velocity (PWV) decreased significantly from 9.95±2.13 m/s to 9.00±1.12 m/s (p=0.019). The lipid profile improved during therapy, with reductions in total cholesterol (p=0.009) and LDL cholesterol (p=0.018).Conclusion. Six-month fixed-combination therapy with telmisartan/amlodipine demonstrated high antihypertensive efficacy, pronounced cardio-, vaso-, and nephroprotective effects, as well as a favorable impact on the metabolic profile in patients with AH, establishing it as a combination of choice, particularly in the presence of cardiometabolic risk factors.

Maqola ma’lumotlari
MualliflarAtoeva, Munisa, Abdullaeva, Guzal, Khamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Khafiza, Mansurova, Vasila, Атоева, М, Абдуллаева, Г, Хамидуллаева, Г, Бекметова, С, Юсупова, Х, Мансурова, В, Atoeva, Munisa, Abdullaeva, Guzal, Xamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Xafiza, Mansurova, Vasila
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-06-29
Jild3
Son2
Betlar43-54
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00086
Indeksga qo‘shilgan2026-10-21

DOI: 10.70626/cardiouz-2026-3-00086 · Maqolaning asl sahifasi

Kalit so‘zlar

cardiovascular diseases, left ventricular hypertrophy, pulse wave velocity, intima-media thickness, сердечно-сосудистые заболевания, гипертрофия левого желудочка, скорость распространения пульсовой волны, толщина комплекса интима-медиа, yurak-qon tomir kasalliklari, chap qorincha gipertrofiyasi, puls to'lqinining tarqalish tezligi, intima-media kompleksining qalinligi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAtoeva, Munisa, Abdullaeva, Guzal, Khamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Khafiza, Mansurova, Vasila, Атоева, М, Абдуллаева, Г, Хамидуллаева, Г, Бекметова, С, Юсупова, Х, Мансурова, В, Atoeva, Munisa, Abdullaeva, Guzal, Xamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Xafiza, & Mansurova, Vasila (2026). The effect of fixed combination therapy with telmisartan/ amlodipine on cardiometabolic risks in patients with arterial hypertension. O‘zbekiston кardiologiyasi, 3(2), 43-54. https://doi.org/10.70626/cardiouz-2026-3-00086
GOST (OAK)Atoeva, Munisa va b. The effect of fixed combination therapy with telmisartan/ amlodipine on cardiometabolic risks in patients with arterial hypertension // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 2. – P. 43-54. – DOI: 10.70626/cardiouz-2026-3-00086.
MLAAtoeva, Munisa, Abdullaeva, Guzal, Khamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Khafiza, Mansurova, Vasila, Атоева, М, Абдуллаева, Г, Хамидуллаева, Г, Бекметова, С, Юсупова, Х, Мансурова, В, Atoeva, Munisa, Abdullaeva, Guzal, Xamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Xafiza, and Mansurova, Vasila. “The effect of fixed combination therapy with telmisartan/ amlodipine on cardiometabolic risks in patients with arterial hypertension.” O‘zbekiston кardiologiyasi, 3(2), 43-54, 2026. https://doi.org/10.70626/cardiouz-2026-3-00086
ChicagoAtoeva, Munisa, Abdullaeva, Guzal, Khamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Khafiza, Mansurova, Vasila, Атоева, М, Абдуллаева, Г, Хамидуллаева, Г, Бекметова, С, Юсупова, Х, Мансурова, В, Atoeva, Munisa, Abdullaeva, Guzal, Xamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Xafiza, and Mansurova, Vasila. “The effect of fixed combination therapy with telmisartan/ amlodipine on cardiometabolic risks in patients with arterial hypertension.” O‘zbekiston кardiologiyasi, 3(2), 43-54 (2026). https://doi.org/10.70626/cardiouz-2026-3-00086
HarvardAtoeva, Munisa, Abdullaeva, Guzal, Khamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Khafiza, Mansurova, Vasila, Атоева, М, Абдуллаева, Г, Хамидуллаева, Г, Бекметова, С, Юсупова, Х, Мансурова, В, Atoeva, Munisa, Abdullaeva, Guzal, Xamidullaeva, Gulnoz, Bekmetova, Sevara, Yusupova, Xafiza, and Mansurova, Vasila (2026) ‘The effect of fixed combination therapy with telmisartan/ amlodipine on cardiometabolic risks in patients with arterial hypertension’, O‘zbekiston кardiologiyasi, 3(2), 43-54. https://doi.org/10.70626/cardiouz-2026-3-00086
BibTeX
@article{atoevamunisa2026,
  title = {The effect of fixed combination therapy with telmisartan/ amlodipine on cardiometabolic risks in patients with arterial hypertension},
  author = {Atoeva, Munisa and Abdullaeva, Guzal and Khamidullaeva, Gulnoz and Bekmetova, Sevara and Yusupova, Khafiza and Mansurova, Vasila and Атоева, М and Абдуллаева, Г and Хамидуллаева, Г and Бекметова, С and Юсупова, Х and Мансурова, В and Atoeva, Munisa and Abdullaeva, Guzal and Xamidullaeva, Gulnoz and Bekmetova, Sevara and Yusupova, Xafiza and Mansurova, Vasila},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {2},
  pages = {43-54},
  doi = {10.70626/cardiouz-2026-3-00086},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00086}
}

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