The Impact of Nocturnal Obstructive Sleep Apnea Syndrome on Cerebrovascular Complications in Patients with Ischemic Heart Disease

Rakhmanov, Eldor, Mahkamova, Nargiza, Рахманов, Э, Махкамова, Н, Raxmanov, Eldor, Mahkamova, Nargiza

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

Obstructive sleep apnea syndrome (OSAS) and ischemic heart disease (IHD) frequently coexist as comorbid conditions that mutually exacerbate one another. The aim of this review is to evaluate the impact of OSAS on cerebrovascular complications in patients with IHD based on a systematic review of the available literature. Ischemic heart disease (IHD) and sleep disorders, particularly obstructive sleep apnea syndrome (OSAS), represent one of the most significant challenges in contemporary medicine. Over the past decade, substantial evidence has demonstrated that the coexistence of these two conditions constitutes an independent risk factor for the development of cerebrovascular diseases. According to the World Health Organization (WHO), cardiovascular diseases accounted for approximately 31% of all global deaths in 2023. Meanwhile, the global prevalence of OSAS is estimated to range from 15% to 30%, with the condition occurring 2–3 times more frequently in men than in women. Among patients with IHD, the prevalence of OSAS is estimated to reach 40–60%. Cerebrovascular complications, including ischemic stroke, transient ischemic attack (TIA), subcortical leukoencephalopathy, and cognitive impairment, are particularly common in patients with concomitant IHD and OSAS. Pathophysiologically, these complications are associated with hypertension, endothelial dysfunction, oxidative stress, and sympathetic overactivation. However, the precise mechanisms underlying these associations remain incompletely understood.

Maqola ma’lumotlari
MualliflarRakhmanov, Eldor, Mahkamova, Nargiza, Рахманов, Э, Махкамова, Н, Raxmanov, Eldor, Mahkamova, Nargiza
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-03-29
Jild3
Son1
Betlar66-74
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00079
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2026-3-00079 · Maqolaning asl sahifasi

Kalit so‘zlar

Obstructive sleep apnea syndrome, ischemic heart disease, ischemic stroke, cerebrovascular complications, CPAP, endothelial dysfunction, cognitive impairment, Синдром обструктивного апноэ сна, ишемическая болезнь сердца, ишемический инсульт, цереброваскулярные осложнения, CPAP, эндотелиальная дисфункция, когнитивные нарушения, Obstruktiv uyqu apnoe sindromi, yurak ishemik kasalligi, ishemik insult, serebrovaskulyar asoratlar, CPAP, endotelial disfunksiya, kognitiv buzilishlar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARakhmanov, Eldor, Mahkamova, Nargiza, Рахманов, Э, Махкамова, Н, Raxmanov, Eldor, & Mahkamova, Nargiza (2026). The Impact of Nocturnal Obstructive Sleep Apnea Syndrome on Cerebrovascular Complications in Patients with Ischemic Heart Disease. O‘zbekiston кardiologiyasi, 3(1), 66-74. https://doi.org/10.70626/cardiouz-2026-3-00079
GOST (OAK)Rakhmanov, Eldor va b. The Impact of Nocturnal Obstructive Sleep Apnea Syndrome on Cerebrovascular Complications in Patients with Ischemic Heart Disease // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 1. – P. 66-74. – DOI: 10.70626/cardiouz-2026-3-00079.
MLARakhmanov, Eldor, Mahkamova, Nargiza, Рахманов, Э, Махкамова, Н, Raxmanov, Eldor, and Mahkamova, Nargiza. “The Impact of Nocturnal Obstructive Sleep Apnea Syndrome on Cerebrovascular Complications in Patients with Ischemic Heart Disease.” O‘zbekiston кardiologiyasi, 3(1), 66-74, 2026. https://doi.org/10.70626/cardiouz-2026-3-00079
ChicagoRakhmanov, Eldor, Mahkamova, Nargiza, Рахманов, Э, Махкамова, Н, Raxmanov, Eldor, and Mahkamova, Nargiza. “The Impact of Nocturnal Obstructive Sleep Apnea Syndrome on Cerebrovascular Complications in Patients with Ischemic Heart Disease.” O‘zbekiston кardiologiyasi, 3(1), 66-74 (2026). https://doi.org/10.70626/cardiouz-2026-3-00079
HarvardRakhmanov, Eldor, Mahkamova, Nargiza, Рахманов, Э, Махкамова, Н, Raxmanov, Eldor, and Mahkamova, Nargiza (2026) ‘The Impact of Nocturnal Obstructive Sleep Apnea Syndrome on Cerebrovascular Complications in Patients with Ischemic Heart Disease’, O‘zbekiston кardiologiyasi, 3(1), 66-74. https://doi.org/10.70626/cardiouz-2026-3-00079
BibTeX
@article{rakhmanoveldor2026,
  title = {The Impact of Nocturnal Obstructive Sleep Apnea Syndrome on Cerebrovascular Complications in Patients with Ischemic Heart Disease},
  author = {Rakhmanov, Eldor and Mahkamova, Nargiza and Рахманов, Э and Махкамова, Н and Raxmanov, Eldor and Mahkamova, Nargiza},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {1},
  pages = {66-74},
  doi = {10.70626/cardiouz-2026-3-00079},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00079}
}

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