Use of SGLT-2 Inhibitors in Acute Myocardial Infarction

aliyeva, Sayyora, Srojidinova, Nigora, Алиева, С, Срожидинова, Н, Aliyeva, Sayyora, Srojidinova, Nigora

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

Cardiorenometabolic syndrome (CRMS) is a multifactorial clinical condition reflecting complex and interrelated pathobiological processes involving the cardiovascular, renal, and metabolic systems. Its central mechanisms include visceral adiposity, insulin resistance, adipokine imbalance, chronic low-grade inflammation (metaflammation), and oxidative stress \cite{1, 2}. This pathological background contributes to the development of acute myocardial infarction (AMI) through endothelial dysfunction, reduced nitric oxide (NO) bioavailability, impaired microvascular perfusion, and destabilization of atherosclerotic plaques. In patients with CRMS, AMI differs from the classical ischemic model, as it is characterized not only by impaired coronary blood flow but also by an intense inflammatory response, activation of the immune system, and disturbances in cellular energy metabolism. During the early phase of infarction, damage-associated molecular patterns (DAMPs) activate Toll-like receptors, initiating the NF-κB signaling pathway and increasing the production of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Furthermore, mitochondrial dysfunction and excessive generation of reactive oxygen species (ROS) amplify oxidative stress, promoting lipid peroxidation, DNA damage, and cardiomyocyte apoptosis. In recent years, sodium-glucose cotransporter-2 (SGLT2) inhibitors, particularly dapagliflozin, have attracted considerable attention as agents with broad cardiorenometabolic benefits. Their therapeutic effects are multifaceted and extend well beyond glycemic control. SGLT2 inhibitors exert cardioprotective effects by suppressing inflammatory signaling pathways (NF-κB and the NLRP3 inflammasome), reducing oxidative stress, restoring mitochondrial function, inhibiting the sodium-hydrogen exchanger-1 (NHE1), and decreasing intracellular calcium overload in cardiomyocytes \cite{9, 12}. This review systematically analyzes the role of SGLT2 inhibitors in the pathogenesis of AMI, their molecular, cellular, and systemic mechanisms of action, and their cardiorenometabolic efficacy based on evidence from contemporary clinical studies, including the DAPA-MI (Dapagliflozin in Myocardial Infarction) trial.

Maqola ma’lumotlari
Mualliflaraliyeva, Sayyora, Srojidinova, Nigora, Алиева, С, Срожидинова, Н, Aliyeva, Sayyora, Srojidinova, Nigora
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-03-29
Jild3
Son1
Betlar58-65
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00078
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2026-3-00078 · Maqolaning asl sahifasi

Kalit so‘zlar

O'tkir miokard infarkti, SGLT2 ingibitorlari, dapagliflozin, kardiorenometabolik sindrom, yallig‘lanish, oksidlovchi stress, ventrikulyar remodeling, kardioproteksiya, mitoxondrial disfunksiya, reperfuziya shikastlanishi, Acute myocardial infarction, SGLT2 inhibitors, dapagliflozin, cardiorenometabolic syndrome, inflammation, oxidative stress, ventricular remodeling, cardioprotection, mitochondrial dysfunction, reperfusion injury, Острый инфаркт миокарда, ингибиторы SGLT2, дапаглифлозин, кардиоренометаболический синдром, воспаление, оксидативный стресс, ремоделирование желудочков, кардиопротекция, митохондриальная дисфункция, реперфузионное повреждение

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAaliyeva, Sayyora, Srojidinova, Nigora, Алиева, С, Срожидинова, Н, Aliyeva, Sayyora, & Srojidinova, Nigora (2026). Use of SGLT-2 Inhibitors in Acute Myocardial Infarction. O‘zbekiston кardiologiyasi, 3(1), 58-65. https://doi.org/10.70626/cardiouz-2026-3-00078
GOST (OAK)aliyeva, Sayyora va b. Use of SGLT-2 Inhibitors in Acute Myocardial Infarction // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 1. – P. 58-65. – DOI: 10.70626/cardiouz-2026-3-00078.
MLAaliyeva, Sayyora, Srojidinova, Nigora, Алиева, С, Срожидинова, Н, Aliyeva, Sayyora, and Srojidinova, Nigora. “Use of SGLT-2 Inhibitors in Acute Myocardial Infarction.” O‘zbekiston кardiologiyasi, 3(1), 58-65, 2026. https://doi.org/10.70626/cardiouz-2026-3-00078
Chicagoaliyeva, Sayyora, Srojidinova, Nigora, Алиева, С, Срожидинова, Н, Aliyeva, Sayyora, and Srojidinova, Nigora. “Use of SGLT-2 Inhibitors in Acute Myocardial Infarction.” O‘zbekiston кardiologiyasi, 3(1), 58-65 (2026). https://doi.org/10.70626/cardiouz-2026-3-00078
Harvardaliyeva, Sayyora, Srojidinova, Nigora, Алиева, С, Срожидинова, Н, Aliyeva, Sayyora, and Srojidinova, Nigora (2026) ‘Use of SGLT-2 Inhibitors in Acute Myocardial Infarction’, O‘zbekiston кardiologiyasi, 3(1), 58-65. https://doi.org/10.70626/cardiouz-2026-3-00078
BibTeX
@article{aliyevasayyora2026,
  title = {Use of SGLT-2 Inhibitors in Acute Myocardial Infarction},
  author = {aliyeva, Sayyora and Srojidinova, Nigora and Алиева, С and Срожидинова, Н and Aliyeva, Sayyora and Srojidinova, Nigora},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {1},
  pages = {58-65},
  doi = {10.70626/cardiouz-2026-3-00078},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00078}
}

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