Aim. To determine the association between polymorphisms of the PITX2 (rs6817105) and KCNN3 (rs13376333) genes and the development of atrial fibrillation (AF) in patients with arterial hypertension (AH) in the Uzbek population. Materials and methods. The study included 154 patients with AH. Among them, paroxysmal AF was initially diagnosed in 21 patients (13.64%), persistent AF in 44 patients (28.57%), and permanent AF in 89 patients (57.79%). At the beginning of the study, the mean age of patients with AH and AF was 64.1±10.35 years. The control group consisted of AH patients without AF (n=91), with a mean age of 56.03±12.18 years. Clinical and instrumental examinations, including ECG, echocardiography, and Holter monitoring, were performed. Molecular genetic analysis of isolated DNA was carried out using real-time PCR. The association of polymorphisms with AF was assessed using logistic regression analysis and various inheritance models. Statistical analysis was performed using Statistica 10.0 and SNPassoc (R) software. Results. The study revealed statistically significant associations between the risk of atrial fibrillation development and the PITX2 gene rs6817105 polymorphism as well as the KCNN3 gene rs13376333 polymorphism in Uzbek patients with arterial hypertension. The PITX2 rs6817105 polymorphism showed a strong association with atrial fibrillation: carriage of the minor C allele increased the risk of AF development 2.76-fold under the log-additive inheritance model (OR = 2.76; p = 3.27×10⁻⁷). The KCNN3 rs13376333 polymorphism also demonstrated a significant association with AF. The C allele was significantly more frequent in patients with rhythm disorders and increased the risk of AF development under the log-additive model (OR = 1.63; p = 0.020). Conclusion. For the first time, an association between the PITX2 gene rs6817105 polymorphism and the KCNN3 gene rs13376333 polymorphism with atrial fibrillation has been identified in AH patients of the Uzbek population. These findings confirm the importance of these genetic markers in the pathogenesis of atrial fibrillation complicated by arterial hypertension and emphasize the relevance of genetic testing in this group of patients.
| Mualliflar | Mashkurova, Zaringiz, Abdullaeva, Guzal, Zakirova, Darya, Rajabova, Gulrux, Xamidullayeva, Gulnoza, Abdullaev, Alisher, Rozibaev, Bekzod, Машкурова, З, Абдуллаева, Г, Закирова, Д, Раджабова, Г, Хамидуллаева, Г, Абдуллаев, А, Розибаев, Б, Mashkurova, Zaringiz, Abdullayeva, Guzal, Zakirova, Darya, Rajabova, Gulrux, Xamidullayeva, Gulnoza, Abdullayev, Alisher, Rozibayev, Bekzod |
|---|---|
| Jurnal | O‘zbekiston кardiologiyasi |
| Nashr sanasi | 2026-03-29 |
| Jild | 3 |
| Son | 1 |
| Betlar | 4-15 |
| Til | O‘zbek |
| DOI | 10.70626/cardiouz-2026-3-00073 |
DOI: 10.70626/cardiouz-2026-3-00073 · Maqolaning asl sahifasi
Arterial hypertension, atrial fibrillation, PITX2 gene rs6817105 polymorphism, KCNN3 gene rs13376333 polymorphism, Артериальная гипертензия, фибрилляция предсердий, полиморфизм rs6817105 гена PITX2, полиморфизм rs13376333 гена KCNN3, Arterial gipertenziya, bo‘lmachalar fibrillyatsiyasi, PITX2 genining rs6817105 polimorfizmi, KCNN3 genining rs13376333 polimorfizmi
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