Clinical efficacy of combined treatment methods in uncontrolled arterial hypertension during pregnancy

Sadulloyeva, M, Zakirova, F, Садуллоева, Мохинур, Закирова, Феруза, Sadulloyeva, M, Zakirova, F

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

Aim: To evaluate the effect of combined antihypertensive therapy on arterial blood pressure parameters in pregnant women with uncontrolled gestational arterial hypertension. Materials and methods: The study included 60 pregnant women diagnosed with gestational arterial hypertension according to the 2018 ESC recommendations, with a gestational age of 20–24 weeks. The patients were randomly divided into two groups: Group 1 (n = 30) — methyldopa (500–1000 mg) + metoprolol succinate (25–50 mg), Group 2 (n = 30) — methyldopa (500–1000 mg) + amlodipine (5–10 mg). In all patients, office arterial blood pressure was measured and 24-hour ambulatory blood pressure monitoring was performed before the initiation of antihypertensive therapy. Results: A significant decrease in systolic, diastolic, and mean arterial blood pressure was recorded in both groups (p < 0.0001). The degree of blood pressure reduction was higher in Group 2 in terms of systolic and diastolic parameters, which may be explained by the vasodilatory effect of amlodipine. Target systolic blood pressure was observed in 75% of patients in Group 1 and 87% of patients in Group 2, while target diastolic blood pressure was observed in 75% and 91% of patients, respectively. However, no statistically significant difference was found between the groups. Conclusion: Both combined antihypertensive therapy regimens ensured the achievement of target arterial blood pressure levels in pregnant women with gestational arterial hypertension. Although the methyldopa and amlodipine combination showed a greater tendency toward blood pressure reduction, larger studies are required to confirm these results.

Maqola ma’lumotlari
MualliflarSadulloyeva, M, Zakirova, F, Садуллоева, Мохинур, Закирова, Феруза, Sadulloyeva, M, Zakirova, F
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-03-29
Jild3
Son1
Betlar16-25
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00074
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2026-3-00074 · Maqolaning asl sahifasi

Kalit so‘zlar

Gestational arterial hypertension, pregnancy, antihypertensive therapy, ABP target values, Гестационная артериальная гипертензия, беременность, антигипертензивная терапия, целевые показатели АД, Gestatsion arterial gipertenziya, homiladorlik, antigipertenziv terapiya, AQBning maqsadli ko‘rsatkichlari

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APASadulloyeva, M, Zakirova, F, Садуллоева, Мохинур, Закирова, Феруза, Sadulloyeva, M, & Zakirova, F (2026). Clinical efficacy of combined treatment methods in uncontrolled arterial hypertension during pregnancy. O‘zbekiston кardiologiyasi, 3(1), 16-25. https://doi.org/10.70626/cardiouz-2026-3-00074
GOST (OAK)Sadulloyeva, M va b. Clinical efficacy of combined treatment methods in uncontrolled arterial hypertension during pregnancy // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 1. – P. 16-25. – DOI: 10.70626/cardiouz-2026-3-00074.
MLASadulloyeva, M, Zakirova, F, Садуллоева, Мохинур, Закирова, Феруза, Sadulloyeva, M, and Zakirova, F. “Clinical efficacy of combined treatment methods in uncontrolled arterial hypertension during pregnancy.” O‘zbekiston кardiologiyasi, 3(1), 16-25, 2026. https://doi.org/10.70626/cardiouz-2026-3-00074
ChicagoSadulloyeva, M, Zakirova, F, Садуллоева, Мохинур, Закирова, Феруза, Sadulloyeva, M, and Zakirova, F. “Clinical efficacy of combined treatment methods in uncontrolled arterial hypertension during pregnancy.” O‘zbekiston кardiologiyasi, 3(1), 16-25 (2026). https://doi.org/10.70626/cardiouz-2026-3-00074
HarvardSadulloyeva, M, Zakirova, F, Садуллоева, Мохинур, Закирова, Феруза, Sadulloyeva, M, and Zakirova, F (2026) ‘Clinical efficacy of combined treatment methods in uncontrolled arterial hypertension during pregnancy’, O‘zbekiston кardiologiyasi, 3(1), 16-25. https://doi.org/10.70626/cardiouz-2026-3-00074
BibTeX
@article{sadulloyevam2026,
  title = {Clinical efficacy of combined treatment methods in uncontrolled arterial hypertension during pregnancy},
  author = {Sadulloyeva, M and Zakirova, F and Садуллоева, Мохинур and Закирова, Феруза and Sadulloyeva, M and Zakirova, F},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {1},
  pages = {16-25},
  doi = {10.70626/cardiouz-2026-3-00074},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00074}
}

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