Aim. The aim of this study was to investigate the relationship between clinical-hemodynamic parameters and inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-α) in patients with dilated cardiomyopathy. Materials and methods. The study included 42 patients (mean age 38.5±1.2 years) with dilated cardiomyopathy and chronic heart failure classified as NYHA functional class II–IV. The patients were divided into two groups: Group I – class II (n=12) and Group II – class III–IV (n=30). Results. As heart failure severity increased (class III–IV), serum levels of C-reactive protein (7.6±1.1 mg/L vs. 4.1±0.6 mg/L, p<0.05), IL-6 (7.5±0.8 pg/mL vs. 4.6±0.2 pg/mL, p<0.01), and TNF- α (8.1±0.9 pg/mL vs. 5.6±0.7 pg/mL, p<0.05) were significantly elevated. These changes were associated with left ventricular dilatation (LVEDD 58±1 mm, p<0.05) and reduced ejection fraction (34.7±1.8%, p<0.05). Conclusion. The findings suggest that inflammatory markers play a crucial role in assessing the severity and prognosis of dilated cardiomyopathy and chronic heart failure.
| Mualliflar | Абдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev , Timur, Raxmatov , Mahmud, Gulomov , Xumoyun, Abdullayev , Timur, Rakhmatov , Mahmud, Gulomov , Khumoyun |
|---|---|
| Jurnal | O‘zbekiston кardiologiyasi |
| Nashr sanasi | 2025-11-10 |
| Jild | 2 |
| Son | 4 |
| Betlar | 348-354 |
| Til | Rus |
| DOI | 10.70626/cardiouz-2025-2-00065 |
DOI: 10.70626/cardiouz-2025-2-00065 · Maqolaning asl sahifasi
dilated cardiomyopathy, chronic heart failure, inflammation, C-reactive protein, interleukin-6, tumor necrosis factor-α, colchicine, дилатационная кардиомиопатия, хроническая сердечная недостаточность, воспаление, С-реактивный белок, интерлейкин-6, фактор некроза опухоли-α, колхицин, dilatatsion katdiomiopatiya, surunkali yurak yetishmovchiligi, yallig‘lanish, C-reaktiv oqsil, interleykin-6, o‘sma nekrozi omili-α, kolxitsin
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