Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy

Абдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev , Timur, Raxmatov , Mahmud, Gulomov , Xumoyun, Abdullayev , Timur, Rakhmatov , Mahmud, Gulomov , Khumoyun

O‘zbekiston кardiologiyasi · 2025-yil

Annotatsiya

Aim. The aim of this study was to investigate the relationship between clinical-hemodynamic parameters and inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-α) in patients with dilated cardiomyopathy. Materials and methods. The study included 42 patients (mean age 38.5±1.2 years) with dilated cardiomyopathy and chronic heart failure classified as NYHA functional class II–IV. The patients were divided into two groups: Group I – class II (n=12) and Group II – class III–IV (n=30). Results. As heart failure severity increased (class III–IV), serum levels of C-reactive protein (7.6±1.1 mg/L vs. 4.1±0.6 mg/L, p<0.05), IL-6 (7.5±0.8 pg/mL vs. 4.6±0.2 pg/mL, p<0.01), and TNF- α (8.1±0.9 pg/mL vs. 5.6±0.7 pg/mL, p<0.05) were significantly elevated. These changes were associated with left ventricular dilatation (LVEDD 58±1 mm, p<0.05) and reduced ejection fraction (34.7±1.8%, p<0.05). Conclusion. The findings suggest that inflammatory markers play a crucial role in assessing the severity and prognosis of dilated cardiomyopathy and chronic heart failure.

Maqola ma’lumotlari
MualliflarАбдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev , Timur, Raxmatov , Mahmud, Gulomov , Xumoyun, Abdullayev , Timur, Rakhmatov , Mahmud, Gulomov , Khumoyun
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2025-11-10
Jild2
Son4
Betlar348-354
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2025-2-00065
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2025-2-00065 · Maqolaning asl sahifasi

Kalit so‘zlar

dilated cardiomyopathy, chronic heart failure, inflammation, C-reactive protein, interleukin-6, tumor necrosis factor-α, colchicine, дилатационная кардиомиопатия, хроническая сердечная недостаточность, воспаление, С-реактивный белок, интерлейкин-6, фактор некроза опухоли-α, колхицин, dilatatsion katdiomiopatiya, surunkali yurak yetishmovchiligi, yallig‘lanish, C-reaktiv oqsil, interleykin-6, o‘sma nekrozi omili-α, kolxitsin

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAАбдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev , Timur, Raxmatov , Mahmud, Gulomov , Xumoyun, Abdullayev , Timur, Rakhmatov , Mahmud, & Gulomov , Khumoyun (2025). Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy. O‘zbekiston кardiologiyasi, 2(4), 348-354. https://doi.org/10.70626/cardiouz-2025-2-00065
GOST (OAK)Абдуллаев, Т va b. Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy // O‘zbekiston кardiologiyasi. – 2025. – T. 2, № 4. – P. 348-354. – DOI: 10.70626/cardiouz-2025-2-00065.
MLAАбдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev , Timur, Raxmatov , Mahmud, Gulomov , Xumoyun, Abdullayev , Timur, Rakhmatov , Mahmud, and Gulomov , Khumoyun. “Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy.” O‘zbekiston кardiologiyasi, 2(4), 348-354, 2025. https://doi.org/10.70626/cardiouz-2025-2-00065
ChicagoАбдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev , Timur, Raxmatov , Mahmud, Gulomov , Xumoyun, Abdullayev , Timur, Rakhmatov , Mahmud, and Gulomov , Khumoyun. “Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy.” O‘zbekiston кardiologiyasi, 2(4), 348-354 (2025). https://doi.org/10.70626/cardiouz-2025-2-00065
HarvardАбдуллаев, Т, Рахматов, М, Гуломов, Х, Abdullayev , Timur, Raxmatov , Mahmud, Gulomov , Xumoyun, Abdullayev , Timur, Rakhmatov , Mahmud, and Gulomov , Khumoyun (2025) ‘Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy’, O‘zbekiston кardiologiyasi, 2(4), 348-354. https://doi.org/10.70626/cardiouz-2025-2-00065
BibTeX
@article{article2025,
  title = {Association between disease severity and systemic inflammation in patients with dilated cardiomyopathy},
  author = {Абдуллаев, Т and Рахматов, М and Гуломов, Х and Abdullayev , Timur and Raxmatov , Mahmud and Gulomov , Xumoyun and Abdullayev , Timur and Rakhmatov , Mahmud and Gulomov , Khumoyun},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2025},
  volume = {2},
  number = {4},
  pages = {348-354},
  doi = {10.70626/cardiouz-2025-2-00065},
  url = {https://doi.org/10.70626/cardiouz-2025-2-00065}
}

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