Lipid metabolism and modern approaches to lipid-lowering therapy

Yakhyoeva, Malika, Alieva, Rano, Shek, Aleksandr, Яхъёева, М, Алиева, Р, Шек, А, Yaxyoeva, Malika, Alieva, Rano, Shek, Aleksandr

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

Lipid metabolism disorders are one of the leading risk factors for the development of atherosclerotic cardiovascular diseases and remain of high importance worldwide. Despite substantial advances in reducing low-density lipoprotein (LDL) cholesterol, many patients still have a residual cardiovascular risk associated with triglyceride-rich lipoproteins, remnant cholesterol, and Lp (a). This review summarizes current information on lipid metabolism, including exogenous and endogenous lipoprotein transport pathways, as well as modern strategies for lipid-lowering therapy, in particular drugs agents targeting PCSK9, ANGPTL3, ApoC III and LP(a). Special attention is paid to promising technologies based on small interfering RNAs, antisense oligonucleotides, and CRISP/Cas9 genomic editing. The collected data indicate that an deeper understanding of the mechanisms of lipid metabolism contributes to the development of innovative treatment methods that can more effectively control dyslipidemia and reduce the risk of cardiovascular complications.

Maqola ma’lumotlari
MualliflarYakhyoeva, Malika, Alieva, Rano, Shek, Aleksandr, Яхъёева, М, Алиева, Р, Шек, А, Yaxyoeva, Malika, Alieva, Rano, Shek, Aleksandr
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-03-30
Jild3
Son1
Betlar75-91
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00080
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2026-3-00080 · Maqolaning asl sahifasi

Kalit so‘zlar

lipid metabolism, atherosclerosis, residual cardiovascular risk, LDL cholesterol, TG, TG-rich lipoproteins, LP(a), lipidlowering therapy, липидный обмен, атеросклероз, остаточный сердечно-сосудистый риск, ХС ЛПНП, ТГ, ТГ-содержащие липопротеины, ЛП (а), гиполипидемическая терапия, lipid almashinuvi, ateroskleroz, qoldiq yurak-qon tomir xavfi, past zichlikdagi lipoproteinlar xolesterini, TG, triglitseridlarga boy lipoproteinlar, LP(a), gipolipidemik terapiya

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAYakhyoeva, Malika, Alieva, Rano, Shek, Aleksandr, Яхъёева, М, Алиева, Р, Шек, А, Yaxyoeva, Malika, Alieva, Rano, & Shek, Aleksandr (2026). Lipid metabolism and modern approaches to lipid-lowering therapy. O‘zbekiston кardiologiyasi, 3(1), 75-91. https://doi.org/10.70626/cardiouz-2026-3-00080
GOST (OAK)Yakhyoeva, Malika va b. Lipid metabolism and modern approaches to lipid-lowering therapy // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 1. – P. 75-91. – DOI: 10.70626/cardiouz-2026-3-00080.
MLAYakhyoeva, Malika, Alieva, Rano, Shek, Aleksandr, Яхъёева, М, Алиева, Р, Шек, А, Yaxyoeva, Malika, Alieva, Rano, and Shek, Aleksandr. “Lipid metabolism and modern approaches to lipid-lowering therapy.” O‘zbekiston кardiologiyasi, 3(1), 75-91, 2026. https://doi.org/10.70626/cardiouz-2026-3-00080
ChicagoYakhyoeva, Malika, Alieva, Rano, Shek, Aleksandr, Яхъёева, М, Алиева, Р, Шек, А, Yaxyoeva, Malika, Alieva, Rano, and Shek, Aleksandr. “Lipid metabolism and modern approaches to lipid-lowering therapy.” O‘zbekiston кardiologiyasi, 3(1), 75-91 (2026). https://doi.org/10.70626/cardiouz-2026-3-00080
HarvardYakhyoeva, Malika, Alieva, Rano, Shek, Aleksandr, Яхъёева, М, Алиева, Р, Шек, А, Yaxyoeva, Malika, Alieva, Rano, and Shek, Aleksandr (2026) ‘Lipid metabolism and modern approaches to lipid-lowering therapy’, O‘zbekiston кardiologiyasi, 3(1), 75-91. https://doi.org/10.70626/cardiouz-2026-3-00080
BibTeX
@article{yakhyoevamalika2026,
  title = {Lipid metabolism and modern approaches to lipid-lowering therapy},
  author = {Yakhyoeva, Malika and Alieva, Rano and Shek, Aleksandr and Яхъёева, М and Алиева, Р and Шек, А and Yaxyoeva, Malika and Alieva, Rano and Shek, Aleksandr},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {1},
  pages = {75-91},
  doi = {10.70626/cardiouz-2026-3-00080},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00080}
}

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