Molecular Genetic Aspects of Sudden Death in Young Individuals

Kurbanov, Ravshanbek, Srojidinova, Nigora, Tursunov, Ergashali, Курбанов, Р, Срожидинова, Н, Турсунов, Э, Kurbanov, Ravshanbek, Srojidinova, Nigora, Tursunov, Ergashali

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

Sudden cardiac death (SCD) in young individuals is a significant medical and social problem, a substantial proportion of which is caused by inherited disorders of myocardial electrical activity. The aim of this review was to summarize current concepts of the molecular genetic mechanisms of sudden cardiac death in young patients. An analytical review was conducted of current national and international scientific publications, clinical guidelines, and molecular genetic research data devoted to inherited channelopathies. It was shown that the main causes of SCD in children and young adults are inherited channelopathies, including long and short QT syndromes, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and early ventricular repolarization syndrome. The role of mutations in ion channel genes and regulatory proteins in the formation of the arrhythmogenic substrate is described. Genetic heterogeneity and the overlapping involvement of individual genes in the pathogenesis of various forms of channelopathies are noted. Timely identification of molecular genetic markers of SCD and comprehensive clinical genetic risk assessment make it possible to improve the prevention of life-threatening arrhythmias and optimize the management of patients and their relatives.

Maqola ma’lumotlari
MualliflarKurbanov, Ravshanbek, Srojidinova, Nigora, Tursunov, Ergashali, Курбанов, Р, Срожидинова, Н, Турсунов, Э, Kurbanov, Ravshanbek, Srojidinova, Nigora, Tursunov, Ergashali
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-03-29
Jild3
Son1
Betlar39-50
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00076
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2026-3-00076 · Maqolaning asl sahifasi

Kalit so‘zlar

Sudden cardiac death, channelopathies, molecular genetic mechanisms, ion channels, arrhythmias, Внезапная сердечная смерть, каналопатии, молекулярно-генетические механизмы, ионные каналы, аритмии, To‘satdan yurak o‘limi, kanalopatiyalar, molekulyar-genetik mexanizmlar, ion kanallari, aritmiyalar

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAKurbanov, Ravshanbek, Srojidinova, Nigora, Tursunov, Ergashali, Курбанов, Р, Срожидинова, Н, Турсунов, Э, Kurbanov, Ravshanbek, Srojidinova, Nigora, & Tursunov, Ergashali (2026). Molecular Genetic Aspects of Sudden Death in Young Individuals. O‘zbekiston кardiologiyasi, 3(1), 39-50. https://doi.org/10.70626/cardiouz-2026-3-00076
GOST (OAK)Kurbanov, Ravshanbek va b. Molecular Genetic Aspects of Sudden Death in Young Individuals // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 1. – P. 39-50. – DOI: 10.70626/cardiouz-2026-3-00076.
MLAKurbanov, Ravshanbek, Srojidinova, Nigora, Tursunov, Ergashali, Курбанов, Р, Срожидинова, Н, Турсунов, Э, Kurbanov, Ravshanbek, Srojidinova, Nigora, and Tursunov, Ergashali. “Molecular Genetic Aspects of Sudden Death in Young Individuals.” O‘zbekiston кardiologiyasi, 3(1), 39-50, 2026. https://doi.org/10.70626/cardiouz-2026-3-00076
ChicagoKurbanov, Ravshanbek, Srojidinova, Nigora, Tursunov, Ergashali, Курбанов, Р, Срожидинова, Н, Турсунов, Э, Kurbanov, Ravshanbek, Srojidinova, Nigora, and Tursunov, Ergashali. “Molecular Genetic Aspects of Sudden Death in Young Individuals.” O‘zbekiston кardiologiyasi, 3(1), 39-50 (2026). https://doi.org/10.70626/cardiouz-2026-3-00076
HarvardKurbanov, Ravshanbek, Srojidinova, Nigora, Tursunov, Ergashali, Курбанов, Р, Срожидинова, Н, Турсунов, Э, Kurbanov, Ravshanbek, Srojidinova, Nigora, and Tursunov, Ergashali (2026) ‘Molecular Genetic Aspects of Sudden Death in Young Individuals’, O‘zbekiston кardiologiyasi, 3(1), 39-50. https://doi.org/10.70626/cardiouz-2026-3-00076
BibTeX
@article{kurbanovravshanbek2026,
  title = {Molecular Genetic Aspects of Sudden Death in Young Individuals},
  author = {Kurbanov, Ravshanbek and Srojidinova, Nigora and Tursunov, Ergashali and Курбанов, Р and Срожидинова, Н and Турсунов, Э and Kurbanov, Ravshanbek and Srojidinova, Nigora and Tursunov, Ergashali},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {1},
  pages = {39-50},
  doi = {10.70626/cardiouz-2026-3-00076},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00076}
}

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