The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting

Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

The progression of chronic heart failure (CHF) after coronary artery bypass grafting (CABG) remains a pressing issue in cardiac surgery. This review systematizes current data on the impact of the A1166C (rs5186) single nucleotide polymorphism of the angiotensin II type 1 receptor gene (AGTR1) on post-infarction remodeling and surgical revascularization outcomes. The molecular genetic mechanism is considered, in which the transition of adenine to cytosine disrupts the binding of microRNA-155 to the gene’s mRNA, leading to pathological overexpression of AT1R on cell membranes. Under conditions of surgical stress, carrying the mutant C allele is associated with systemic inflammation, endothelial dysfunction, accelerated myocardial fibrosis, an increased risk of graft thrombosis, and the development of atrial fibrillation. Special attention is paid to the pharmacogenetic aspect: the phenomenon of "escape"during ACE inhibitor therapy is described in carriers of the C allele, which makes the prioritized prescription of angiotensin receptor blockers (ARBs/sartans) pathogenetically justified. The clinical significance of genotyping the rs5186 locus for personalizing neurohumoral blockade and improving the long-term prognosis of patients is emphasized.

Maqola ma’lumotlari
MualliflarUmerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-06-29
Jild3
Son2
Betlar55-62
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00087
Indeksga qo‘shilgan2026-10-21

DOI: 10.70626/cardiouz-2026-3-00087 · Maqolaning asl sahifasi

Kalit so‘zlar

хроническая сердечная недостаточность, аортокоронарное шунтирование, ген AGTR1, полиморфизм А1166С, rs5186, фармакогенетика, ремоделирование миокарда, ренин-ангиотензин-альдостероновая система, chronic heart failure, coronary artery bypass grafting, AGTR1 gene, A1166C polymorphism, rs5186, pharmacogenetics, myocardial remodeling, renin–angiotensin–aldosterone system, surunkali yurak yetishmovchiligi, aortokoronar shuntlash, AGTR1 geni, A1166C polimorfizmi, rs5186, farmakogenetika, miokard remodellanishi, renin-angiotenzin-aldosteron tizimi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUmerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, & Kurbanov, Nurali (2026). The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting. O‘zbekiston кardiologiyasi, 3(2), 55-62. https://doi.org/10.70626/cardiouz-2026-3-00087
GOST (OAK)Umerov, Suleyman va b. The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 2. – P. 55-62. – DOI: 10.70626/cardiouz-2026-3-00087.
MLAUmerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, and Kurbanov, Nurali. “The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting.” O‘zbekiston кardiologiyasi, 3(2), 55-62, 2026. https://doi.org/10.70626/cardiouz-2026-3-00087
ChicagoUmerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, and Kurbanov, Nurali. “The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting.” O‘zbekiston кardiologiyasi, 3(2), 55-62 (2026). https://doi.org/10.70626/cardiouz-2026-3-00087
HarvardUmerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, Kurbanov, Nurali, Умеров, С, Курбанов, Нурали, Ганиев, О, Юсупов, Ж, Курбанов, Н, Umerov, Suleyman, Asanov, David, Ganiyev, Otamurod, Yusupov, Jorabek, and Kurbanov, Nurali (2026) ‘The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting’, O‘zbekiston кardiologiyasi, 3(2), 55-62. https://doi.org/10.70626/cardiouz-2026-3-00087
BibTeX
@article{umerovsuleyman2026,
  title = {The role of agtr1 gene a1166c (rs5186) polymorphism in the clinical course of chronic heart failure in patients after coronary artery bypass grafting},
  author = {Umerov, Suleyman and Asanov, David and Ganiyev, Otamurod and Yusupov, Jorabek and Kurbanov, Nurali and Умеров, С and Курбанов, Нурали and Ганиев, О and Юсупов, Ж and Курбанов, Н and Umerov, Suleyman and Asanov, David and Ganiyev, Otamurod and Yusupov, Jorabek and Kurbanov, Nurali},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {2},
  pages = {55-62},
  doi = {10.70626/cardiouz-2026-3-00087},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00087}
}

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