The PRMT–ADMA–DDAH Axis in Cardiovascular Disease: Linking Protein Arginine Methylation to Endothelial Dysfunction and Vascular Remodeling.

Makhkamova, Munisakhon, Nurillaeva, Nargiza, Махкамова, Мунисахон, Нуриллаева, Н, Maxkamova, Munisaxon, Nurillaeva, Nargiza

O‘zbekiston кardiologiyasi · 2026-yil

Annotatsiya

Endothelial dysfunction is a central pathophysiological process underlying the initiation and progression of cardiovascular disease and is characterized by impaired nitric oxide (NO) bioavailability, increased oxidative stress, inflammation, vasoconstriction, and prothrombotic vascular signaling. Among the endogenous regulators of the NO pathway, asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, has emerged as an important molecular link between metabolic stress and vascular dysfunction. However, circulating ADMA represents only one component of a broader regulatory network involving protein arginine methyltransferases (PRMTs), dimethylarginine dimethylaminohydrolases (DDAHs), and alternative methylarginine-metabolizing pathways. This review examines the molecular architecture of the PRMT–ADMA–DDAH–eNOS/NO axis and its contribution to atherosclerosis, coronary artery disease, hypertension, heart failure, cardiometabolic disorders, chronic kidney disease, and metabolic dysfunction-associated steatotic liver disease. Finally, we discuss the therapeutic potential and limitations of targeting PRMT activity, ADMA metabolism, DDAH1, AGXT2, and NO bioavailability. Understanding this regulatory network may provide a mechanistic framework for identifying endothelial phenotypes of residual cardiovascular risk and developing more individualized strategies for cardiovascular prevention and treatment.

Maqola ma’lumotlari
MualliflarMakhkamova, Munisakhon, Nurillaeva, Nargiza, Махкамова, Мунисахон, Нуриллаева, Н, Maxkamova, Munisaxon, Nurillaeva, Nargiza
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2026-09-02
Jild3
Son2
Betlar73-84
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2026-3-00090
Indeksga qo‘shilgan2026-10-21

DOI: 10.70626/cardiouz-2026-3-00090 · Maqolaning asl sahifasi

Kalit so‘zlar

PRMT1, ADMA, DDAH1, DDAH2, AGXT2, endothelial dysfunction, nitric oxide, eNOS, oxidative stress, cardiovascular disease;, cardiometabolic risk, PRMT1, ADMA, DDAH1, DDAH2, AGXT2, эндотелиальная дисфункция, eNOS, окислительный стресс, кардиометаболический риск, PRMT1, ADMA, DDAH1, DDAH2, AGXT2, endotelial disfunksiya, azot oksidi, oksidativ stress, yurak-qon tomir kasalliklari, kardiometabolik xavf

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMakhkamova, Munisakhon, Nurillaeva, Nargiza, Махкамова, Мунисахон, Нуриллаева, Н, Maxkamova, Munisaxon, & Nurillaeva, Nargiza (2026). The PRMT–ADMA–DDAH Axis in Cardiovascular Disease: Linking Protein Arginine Methylation to Endothelial Dysfunction and Vascular Remodeling.. O‘zbekiston кardiologiyasi, 3(2), 73-84. https://doi.org/10.70626/cardiouz-2026-3-00090
GOST (OAK)Makhkamova, Munisakhon va b. The PRMT–ADMA–DDAH Axis in Cardiovascular Disease: Linking Protein Arginine Methylation to Endothelial Dysfunction and Vascular Remodeling. // O‘zbekiston кardiologiyasi. – 2026. – T. 3, № 2. – P. 73-84. – DOI: 10.70626/cardiouz-2026-3-00090.
MLAMakhkamova, Munisakhon, Nurillaeva, Nargiza, Махкамова, Мунисахон, Нуриллаева, Н, Maxkamova, Munisaxon, and Nurillaeva, Nargiza. “The PRMT–ADMA–DDAH Axis in Cardiovascular Disease: Linking Protein Arginine Methylation to Endothelial Dysfunction and Vascular Remodeling..” O‘zbekiston кardiologiyasi, 3(2), 73-84, 2026. https://doi.org/10.70626/cardiouz-2026-3-00090
ChicagoMakhkamova, Munisakhon, Nurillaeva, Nargiza, Махкамова, Мунисахон, Нуриллаева, Н, Maxkamova, Munisaxon, and Nurillaeva, Nargiza. “The PRMT–ADMA–DDAH Axis in Cardiovascular Disease: Linking Protein Arginine Methylation to Endothelial Dysfunction and Vascular Remodeling..” O‘zbekiston кardiologiyasi, 3(2), 73-84 (2026). https://doi.org/10.70626/cardiouz-2026-3-00090
HarvardMakhkamova, Munisakhon, Nurillaeva, Nargiza, Махкамова, Мунисахон, Нуриллаева, Н, Maxkamova, Munisaxon, and Nurillaeva, Nargiza (2026) ‘The PRMT–ADMA–DDAH Axis in Cardiovascular Disease: Linking Protein Arginine Methylation to Endothelial Dysfunction and Vascular Remodeling.’, O‘zbekiston кardiologiyasi, 3(2), 73-84. https://doi.org/10.70626/cardiouz-2026-3-00090
BibTeX
@article{makhkamovamunisakhon2026,
  title = {The PRMT–ADMA–DDAH Axis in Cardiovascular Disease: Linking Protein Arginine Methylation to Endothelial Dysfunction and Vascular Remodeling.},
  author = {Makhkamova, Munisakhon and Nurillaeva, Nargiza and Махкамова, Мунисахон and Нуриллаева, Н and Maxkamova, Munisaxon and Nurillaeva, Nargiza},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2026},
  volume = {3},
  number = {2},
  pages = {73-84},
  doi = {10.70626/cardiouz-2026-3-00090},
  url = {https://doi.org/10.70626/cardiouz-2026-3-00090}
}

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