Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease

Нуриллаева, Н, Срожидинова, Н, Махкамова, М, Хафизова, Л., Nurillayeva , Nargiza, Srojidinova, Nigora, Maxkamova, Munisaxon, Xafizova , Lola, Nurillayeva, Nargiza, Srojidinova , Nigora, Makhkamova, Munisakhon, Khafizova, Lola

O‘zbekiston кardiologiyasi · 2025-yil

Annotatsiya

This review synthesizes current evidence on early biomarkers of endothelial dysfunction (ED) in cardiovascular disease (CVD), emphasizing their role in diagnosis, prognosis, and management. ED, characterized by reduced nitric oxide bioavailability and increased inflammation, serves as a reversible precursor to atherosclerosis, thrombosis, and events like myocardial infarction. Established biomarkers, including adhesion molecules, cytokines, and inflammatory markers, reflect endothelial activation and predict CVD risk, with recent studies confirming their utility in hypertension. Emerging focus on L-arginine derivatives, particularly asymmetric dimethylarginine (ADMA), highlights its specificity as an endogenous nitric oxide synthase inhibitor, associated with vascular impairment in hypertension, diabetes, and CVD. Clinical trials, such as the AtheroGene and Framingham Offspring studies, demonstrate ADMA’s prognostic value for major adverse events. Future directions advocate integrating ADMA into multi-biomarker panels with AI and omics for personalized medicine, addressing gaps in standardization and early detection. Non-invasive techniques like flow-mediated dilation and ultrasound-derived markers complement biomarkers for subclinical CVD assessment. Overall, biomarker-driven strategies promise enhanced CVD prevention and tailored therapies.

Maqola ma’lumotlari
MualliflarНуриллаева, Н, Срожидинова, Н, Махкамова, М, Хафизова, Л., Nurillayeva , Nargiza, Srojidinova, Nigora, Maxkamova, Munisaxon, Xafizova , Lola, Nurillayeva, Nargiza, Srojidinova , Nigora, Makhkamova, Munisakhon, Khafizova, Lola
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2025-09-30
Jild2
Son3
Betlar264-272
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2025-2-57
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2025-2-57 · Maqolaning asl sahifasi

Kalit so‘zlar

endothelial dysfunction, asymmetric dimethylarginine, homeostasis, nitric oxide, biomarker, эндотелиальная дисфункция, асимметричный диметиларгинин, гомеостаз, оксид азота, биомаркер, endotel disfunktsiyasi, yurak-qon tomir kasalligi, asimmetrik dimetilarginin, gomeostaz, azot oksidi, biomarker

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAНуриллаева, Н, Срожидинова, Н, Махкамова, М, Хафизова, Л., Nurillayeva , Nargiza, Srojidinova, Nigora, Maxkamova, Munisaxon, Xafizova , Lola, Nurillayeva, Nargiza, Srojidinova , Nigora, Makhkamova, Munisakhon, & Khafizova, Lola (2025). Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease. O‘zbekiston кardiologiyasi, 2(3), 264-272. https://doi.org/10.70626/cardiouz-2025-2-57
GOST (OAK)Нуриллаева, Н va b. Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease // O‘zbekiston кardiologiyasi. – 2025. – T. 2, № 3. – P. 264-272. – DOI: 10.70626/cardiouz-2025-2-57.
MLAНуриллаева, Н, Срожидинова, Н, Махкамова, М, Хафизова, Л., Nurillayeva , Nargiza, Srojidinova, Nigora, Maxkamova, Munisaxon, Xafizova , Lola, Nurillayeva, Nargiza, Srojidinova , Nigora, Makhkamova, Munisakhon, and Khafizova, Lola. “Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease.” O‘zbekiston кardiologiyasi, 2(3), 264-272, 2025. https://doi.org/10.70626/cardiouz-2025-2-57
ChicagoНуриллаева, Н, Срожидинова, Н, Махкамова, М, Хафизова, Л., Nurillayeva , Nargiza, Srojidinova, Nigora, Maxkamova, Munisaxon, Xafizova , Lola, Nurillayeva, Nargiza, Srojidinova , Nigora, Makhkamova, Munisakhon, and Khafizova, Lola. “Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease.” O‘zbekiston кardiologiyasi, 2(3), 264-272 (2025). https://doi.org/10.70626/cardiouz-2025-2-57
HarvardНуриллаева, Н, Срожидинова, Н, Махкамова, М, Хафизова, Л., Nurillayeva , Nargiza, Srojidinova, Nigora, Maxkamova, Munisaxon, Xafizova , Lola, Nurillayeva, Nargiza, Srojidinova , Nigora, Makhkamova, Munisakhon, and Khafizova, Lola (2025) ‘Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease’, O‘zbekiston кardiologiyasi, 2(3), 264-272. https://doi.org/10.70626/cardiouz-2025-2-57
BibTeX
@article{article2025,
  title = {Early biomarkers of endothelial dysfunction: clinical implications for the diagnosis and management of cardiovascular disease},
  author = {Нуриллаева, Н and Срожидинова, Н and Махкамова, М and Хафизова, Л. and Nurillayeva , Nargiza and Srojidinova, Nigora and Maxkamova, Munisaxon and Xafizova , Lola and Nurillayeva, Nargiza and Srojidinova , Nigora and Makhkamova, Munisakhon and Khafizova, Lola},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2025},
  volume = {2},
  number = {3},
  pages = {264-272},
  doi = {10.70626/cardiouz-2025-2-57},
  url = {https://doi.org/10.70626/cardiouz-2025-2-57}
}

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