The impact of ulinastatin in complex therapy on the incidence of early postoperative complications after coronary artery bypass grafting

Юсупов , Ж, Матлубов, М, Кушназаров , Р, Yusupov, Jasur, Matlubov, Mansur, Kushnazarov, Rustam, Yusupov, Jasur, Matlubov, Mansur, Kushnazarov , Rustam

O‘zbekiston кardiologiyasi · 2025-yil

Annotatsiya

Aim. To evaluate the effectiveness of ulinastatin as part of complex therapy in reducing the incidence of early postoperative complications in patients with multivessel coronary artery disease after CABG. Materials and methods. The study included 160 patients treated in the cardiac surgery intensive care unit. They were divided into a main group (80 patients, who underwent risk prediction using a multifactorial scale and received ulinastatin) and a control group (80 patients, who received standard treatment). Research methods comprised clinical observation, application of the prognostic risk assessment scale, laboratory determination of inflammatory markers, and statistical analysis using Student’s t-test, the Mann–Whitney test, and Pearson’s correlation. Results. In the main group, the incidence of hyperthermia and pneumonia was 50% and 10%, compared with 100% and 12.5% in the control group. ARDS and multiple organ failure were three times less frequent (1.25% vs. 3.75%), mediastinitis occurred in 1.25% vs. 3.75%, and postoperative wound infection in 3.75% vs. 6.25%. No lethal outcomes were recorded in the main group, whereas mortality in the control group reached 2.5%. Conclusion. The combined use of a multifactorial risk prediction scale and ulinastatin reduces the severity of systemic inflammatory response, lowers the frequency of early complications, and prevents mortality after CABG.

Maqola ma’lumotlari
MualliflarЮсупов , Ж, Матлубов, М, Кушназаров , Р, Yusupov, Jasur, Matlubov, Mansur, Kushnazarov, Rustam, Yusupov, Jasur, Matlubov, Mansur, Kushnazarov , Rustam
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2025-12-05
Jild2
Son4
Betlar330-337
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2025-2-00063
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2025-2-00063 · Maqolaning asl sahifasi

Kalit so‘zlar

Аортокоронарное шунтирование, послеоперационные осложнение, улинастатин, шкала прогнозирования, Coronary artery bypass grafting, postoperative complications, ulinastatin, risk prediction scale, Aortokoronar shuntlash, operatsiyadan keyingi asoratlar, ulinastatin, prognozlash shkalasi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAЮсупов , Ж, Матлубов, М, Кушназаров , Р, Yusupov, Jasur, Matlubov, Mansur, Kushnazarov, Rustam, Yusupov, Jasur, Matlubov, Mansur, & Kushnazarov , Rustam (2025). The impact of ulinastatin in complex therapy on the incidence of early postoperative complications after coronary artery bypass grafting. O‘zbekiston кardiologiyasi, 2(4), 330-337. https://doi.org/10.70626/cardiouz-2025-2-00063
GOST (OAK)Юсупов , Ж va b. The impact of ulinastatin in complex therapy on the incidence of early postoperative complications after coronary artery bypass grafting // O‘zbekiston кardiologiyasi. – 2025. – T. 2, № 4. – P. 330-337. – DOI: 10.70626/cardiouz-2025-2-00063.
MLAЮсупов , Ж, Матлубов, М, Кушназаров , Р, Yusupov, Jasur, Matlubov, Mansur, Kushnazarov, Rustam, Yusupov, Jasur, Matlubov, Mansur, and Kushnazarov , Rustam. “The impact of ulinastatin in complex therapy on the incidence of early postoperative complications after coronary artery bypass grafting.” O‘zbekiston кardiologiyasi, 2(4), 330-337, 2025. https://doi.org/10.70626/cardiouz-2025-2-00063
ChicagoЮсупов , Ж, Матлубов, М, Кушназаров , Р, Yusupov, Jasur, Matlubov, Mansur, Kushnazarov, Rustam, Yusupov, Jasur, Matlubov, Mansur, and Kushnazarov , Rustam. “The impact of ulinastatin in complex therapy on the incidence of early postoperative complications after coronary artery bypass grafting.” O‘zbekiston кardiologiyasi, 2(4), 330-337 (2025). https://doi.org/10.70626/cardiouz-2025-2-00063
HarvardЮсупов , Ж, Матлубов, М, Кушназаров , Р, Yusupov, Jasur, Matlubov, Mansur, Kushnazarov, Rustam, Yusupov, Jasur, Matlubov, Mansur, and Kushnazarov , Rustam (2025) ‘The impact of ulinastatin in complex therapy on the incidence of early postoperative complications after coronary artery bypass grafting’, O‘zbekiston кardiologiyasi, 2(4), 330-337. https://doi.org/10.70626/cardiouz-2025-2-00063
BibTeX
@article{article2025,
  title = {The impact of ulinastatin in complex therapy on the incidence of early postoperative complications after coronary artery bypass grafting},
  author = {Юсупов , Ж and Матлубов, М and Кушназаров , Р and Yusupov, Jasur and Matlubov, Mansur and Kushnazarov, Rustam and Yusupov, Jasur and Matlubov, Mansur and Kushnazarov , Rustam},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2025},
  volume = {2},
  number = {4},
  pages = {330-337},
  doi = {10.70626/cardiouz-2025-2-00063},
  url = {https://doi.org/10.70626/cardiouz-2025-2-00063}
}

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