Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome

Kim, Andrey, Shek, Aleksandr, Alieva, Rano, Ким, Андрей, Шек, Александр, Алиева, Рано, Kim, Andrey, Shek, Aleksandr, Aliyeva, Rano

O‘zbekiston кardiologiyasi · 2025-yil

Annotatsiya

Aim. To evaluate the influence of combined hypolipidemic therapy (statins in combination with ezetimibe and fenofibrate) and sodium-glucose cotransporter 2 inhibitors on epicardial fat thickness in patients with coronary heart disease and metabolic syndrome. Materials and methods: The study included 49 patients with coronary heart disease and metabolic syndrome who underwent treatment at the Republican Specialized Scientific and Practical Medical Center of Cardiology. The patients were divided into 2 groups: 1) intensive statin therapy in combination with ezetimibe, 2) with the addition of fenofibrate and SGLT2 inhibitors. All patients underwent biochemical tests and imaging marker assessments, followed by comparison of the dynamics within and between groups. Results. When comparing two groups receiving different types of therapy, both groups demonstrated a significant decrease in lipid parameters: LDL-C p<0.001, TC p<0.001, TG p<0.001. Additionally, the group treated with fenofibrate and SGLT2 inhibitors showed a more significant reduction in epicardial fat (11.4 mm in the first group and 10.4 mm in the second group, p<0.05). Conclusion: Pathogenetic therapy with the inclusion of fenofibrate and SGLT2 inhibitors more effectively reduces the level of EFT, as well as TG, VLDL-C, and the TG/HDL index.

Maqola ma’lumotlari
MualliflarKim, Andrey, Shek, Aleksandr, Alieva, Rano, Ким, Андрей, Шек, Александр, Алиева, Рано, Kim, Andrey, Shek, Aleksandr, Aliyeva, Rano
JurnalO‘zbekiston кardiologiyasi
NashriyotЎзбекистон кардиологлар ассоциацияси
ISSN3060-4850
Nashr sanasi2025-09-30
Jild2
Son3
Betlar202-211
TilIngliz
Ilmiy sohaTibbiyot
DOI10.70626/cardiouz-2025-2-00052
Indeksga qo‘shilgan2026-08-26

DOI: 10.70626/cardiouz-2025-2-00052 · Maqolaning asl sahifasi

Kalit so‘zlar

coronary artery disease, epicardial fat thickness, sodium glucose co-transporter 2 inhibitors, metabolic syndrome, fenofibrate, толщина эпикардиального жира, ишемическая болезнь сердца, ингибиторы натрий глюкозного котранспортера 2, метаболический синдром, фенофибрат, Epikardial yog‘ qatlami qalinligi, yurak ishemik kasalligi, natriy-glyukoza kotransporter 2 ingibitorlari, metabolik sindrom, fenofibrat

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Tibbiyot

Iqtibos keltirish

APAKim, Andrey, Shek, Aleksandr, Alieva, Rano, Ким, Андрей, Шек, Александр, Алиева, Рано, Kim, Andrey, Shek, Aleksandr, & Aliyeva, Rano (2025). Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome. O‘zbekiston кardiologiyasi, 2(3), 202-211. https://doi.org/10.70626/cardiouz-2025-2-00052
GOST (OAK)Kim, Andrey va b. Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome // O‘zbekiston кardiologiyasi. – 2025. – T. 2, № 3. – P. 202-211. – DOI: 10.70626/cardiouz-2025-2-00052.
MLAKim, Andrey, Shek, Aleksandr, Alieva, Rano, Ким, Андрей, Шек, Александр, Алиева, Рано, Kim, Andrey, Shek, Aleksandr, and Aliyeva, Rano. “Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome.” O‘zbekiston кardiologiyasi, 2(3), 202-211, 2025. https://doi.org/10.70626/cardiouz-2025-2-00052
ChicagoKim, Andrey, Shek, Aleksandr, Alieva, Rano, Ким, Андрей, Шек, Александр, Алиева, Рано, Kim, Andrey, Shek, Aleksandr, and Aliyeva, Rano. “Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome.” O‘zbekiston кardiologiyasi, 2(3), 202-211 (2025). https://doi.org/10.70626/cardiouz-2025-2-00052
HarvardKim, Andrey, Shek, Aleksandr, Alieva, Rano, Ким, Андрей, Шек, Александр, Алиева, Рано, Kim, Andrey, Shek, Aleksandr, and Aliyeva, Rano (2025) ‘Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome’, O‘zbekiston кardiologiyasi, 2(3), 202-211. https://doi.org/10.70626/cardiouz-2025-2-00052
BibTeX
@article{kimandrey2025,
  title = {Influence of combined pathogenetic treatment on the dynamics of epicardial fat thickness in patients with cad and metabolic syndrome},
  author = {Kim, Andrey and Shek, Aleksandr and Alieva, Rano and Ким, Андрей and Шек, Александр and Алиева, Рано and Kim, Andrey and Shek, Aleksandr and Aliyeva, Rano},
  journal = {O‘zbekiston кardiologiyasi},
  year = {2025},
  volume = {2},
  number = {3},
  pages = {202-211},
  doi = {10.70626/cardiouz-2025-2-00052},
  url = {https://doi.org/10.70626/cardiouz-2025-2-00052}
}

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