POST-COVID-19 diabetes mellitus in a cross-sectional study: autoimmune disease with endothelial dysfunction?

Алиева Анна Валерьевна, Хайдарова Феруза Алимовна, Халилова Диловар Захриддиновна, Саидова Саодат Хожиакбаровна, Салимова Алинур Самадовна, Арипова Малика Дильшадовна

Марказий Осиё эндокринологик журнали · 2025-yil

Annotatsiya

Purpose: To study the characteristics of diabetes occurring after contracting COVID-19. Methods: Hemostasis parameters, vitamin D levels, and beta cell-specific autoantibodies were tested in 70 patients with post-COVID-19-diagnosed diabetes. Results: In our cross-sectional study, we found a relatively high incidence of type 1 DM (16.7%) and LADA (4.76%) among adults who were diagnosed with DM after COVID-19. Adult patients with type 1 DM were younger, predominantly female, and had a high rate of family history of DM. The majority of patients with type 1 DM had mild COVID-19 and did not use corticosteroids during acute COVID-19. Patients with severe or mild COVID-19 also had a risk of diabetes onset. All patients with newly diagnosed DM had low vitamin D levels, although Uzbekistan has good insolation. New cases of DM were registered within 0 to 24 months after COVID-19. The majority of type 1 patients were diagnosed during the first 2 months and at 15-20 months after acute COVID-19. The incidence of new type 2 DM cases was consistent during the 2-year period after COVID-19. As expected, patients with type 2 HELLP syndrome had high D-dimer and von Willebrand factor levels. Type 1 DM patients, both adults and children, also had increased D-dimer and von Willebrand factor levels. VCAM-1 levels were high in all patients, including children, with the highest levels occurring in patients with LADA, indicating endothelial dysfunction. Conclusion. The increased incidence of type 1 DM with positive diabetes-specific antibodies after COVID-19 indicates damage to islet cells and their components by SARS-CoV-2 with further activation of autoimmune mechanisms. Young females with a family history of DM who were diagnosed with diabetes after COVID-19 should be tested for diabetes-specific antibodies for proper differentiation of the type of disease and timely insulin treatment. Type 1 DM that develops after COVID-19 should be treated as a disease associated with CVD and endothelial dysfunction.

Maqola ma’lumotlari
MualliflarАлиева Анна Валерьевна, Хайдарова Феруза Алимовна, Халилова Диловар Захриддиновна, Саидова Саодат Хожиакбаровна, Салимова Алинур Самадовна, Арипова Малика Дильшадовна
JurnalМарказий Осиё эндокринологик журнали
NashriyotРеспублика ихтисослаштирилган эндокринология илмий-амалий тиббиёт маркази
ISSN2181-3426
Nashr sanasi2025-01-24
Jild4
Son3
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-09-06

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Kalit so‘zlar

пост-COVID-19, эндотелиальная дисфункция, ICAM-1, VCAM-1, диабетспецифические антитела, post-COVID-19, endothelial dysfunction, ICAM-1, VCAM-1, diabetes-specific antibodies, post-COVID-19, endoteliya disfunktsiyasi, ICAM-1, VCAM-1, diabetga xos antitanachalar

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Iqtibos keltirish

APAАлиева Анна Валерьевна, Хайдарова Феруза Алимовна, Халилова Диловар Захриддиновна, Саидова Саодат Хожиакбаровна, Салимова Алинур Самадовна, & Арипова Малика Дильшадовна (2025). POST-COVID-19 DIABETES MELLITUS IN A CROSS-SECTIONAL STUDY: AUTOIMMUNE DISEASE WITH ENDOTHELIAL DYSFUNCTION?. Марказий Осиё эндокринологик журнали, 4(3). https://www.tadqiqot.uz/index.php/cae/article/view/10747
GOST (OAK)Алиева Анна Валерьевна va b. POST-COVID-19 DIABETES MELLITUS IN A CROSS-SECTIONAL STUDY: AUTOIMMUNE DISEASE WITH ENDOTHELIAL DYSFUNCTION? // Марказий Осиё эндокринологик журнали. – 2025. – T. 4, № 3.
MLAАлиева Анна Валерьевна, Хайдарова Феруза Алимовна, Халилова Диловар Захриддиновна, Саидова Саодат Хожиакбаровна, Салимова Алинур Самадовна, and Арипова Малика Дильшадовна. “POST-COVID-19 DIABETES MELLITUS IN A CROSS-SECTIONAL STUDY: AUTOIMMUNE DISEASE WITH ENDOTHELIAL DYSFUNCTION?.” Марказий Осиё эндокринологик журнали, 4(3), 2025. https://www.tadqiqot.uz/index.php/cae/article/view/10747
ChicagoАлиева Анна Валерьевна, Хайдарова Феруза Алимовна, Халилова Диловар Захриддиновна, Саидова Саодат Хожиакбаровна, Салимова Алинур Самадовна, and Арипова Малика Дильшадовна. “POST-COVID-19 DIABETES MELLITUS IN A CROSS-SECTIONAL STUDY: AUTOIMMUNE DISEASE WITH ENDOTHELIAL DYSFUNCTION?.” Марказий Осиё эндокринологик журнали, 4(3) (2025). https://www.tadqiqot.uz/index.php/cae/article/view/10747
HarvardАлиева Анна Валерьевна, Хайдарова Феруза Алимовна, Халилова Диловар Захриддиновна, Саидова Саодат Хожиакбаровна, Салимова Алинур Самадовна, and Арипова Малика Дильшадовна (2025) ‘POST-COVID-19 DIABETES MELLITUS IN A CROSS-SECTIONAL STUDY: AUTOIMMUNE DISEASE WITH ENDOTHELIAL DYSFUNCTION?’, Марказий Осиё эндокринологик журнали, 4(3). https://www.tadqiqot.uz/index.php/cae/article/view/10747
BibTeX
@article{article2025,
  title = {POST-COVID-19 DIABETES MELLITUS IN A CROSS-SECTIONAL STUDY: AUTOIMMUNE DISEASE WITH ENDOTHELIAL DYSFUNCTION?},
  author = {Алиева Анна Валерьевна and Хайдарова Феруза Алимовна and Халилова Диловар Захриддиновна and Саидова Саодат Хожиакбаровна and Салимова Алинур Самадовна and Арипова Малика Дильшадовна},
  journal = {Марказий Осиё эндокринологик журнали},
  year = {2025},
  volume = {4},
  number = {3},
  url = {https://www.tadqiqot.uz/index.php/cae/article/view/10747}
}

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