Diabetic retinopathy (DR) is recognised as the leading cause of blindness and low vision among people of working age. Diagnosis and grading of the disease is based on detection and statement, first of all, of vascular changes in the retina: haemorrhages, microaneurysms, non-vascular zones and newly formed vessels. However, in the last decade, there has been considerable research and data suggesting that retinal neurodegeneration occurs at earlier stages than vascular abnormalities. This suggests that neuronal damage may play a key role in the development of the disease and may be considered as an independent therapeutic target. This review will discuss the existing evidence and its possible clinical implications for understanding diabetic retinal neurodegeneration. Accumulating research data show that patients with qandli diabet(QD) experience progressive to’r parda thinning and visual impairment even before signs of diabetic retinopathy appear. At the same time, modern methods of to’r parda vascular imaging show signs of vascular remodelling and chorioideal changes at early stages. Histological studies of tissues from experimental animals with diabetes and in-vitro experiments confirm that QD can directly affect to’r parda nerve and glial cells, supporting the hypothesis that to’r parda neurodegeneration begins early in the disease and revealing possible disease mechanisms and potential targets for treatment.
| Mualliflar | Ботирхужа Лазизхужа Бобир угли, Юлдашева Нодира Махмуджановна |
|---|---|
| Jurnal | Марказий Осиё эндокринологик журнали |
| Nashr sanasi | 2025-01-24 |
| Jild | 4 |
| Son | 3 |
| Til | Rus |
Диабетическая ретинопатия, нейродегенерация, сахарный диабет,, эпидемиология, факторы риска, Diabetic retinopathy, neurodegeneration, diabetes mellitus, Epidemiology, risk factors, Diabetik retinopatiya, neyrodegeneratsiya, qandli diabet, epidemiologiya, xavf omillari
Purpose: To study the characteristics of diabetes occurring after contracting COVID-19. Methods: Hemostasis parameters, vitamin D levels, and beta cell-specific autoantibodies were tested in 70 patients with…
Currently, thyroid gland (TG) diseases with nodular formations are widespread, and due to ultrasound examination, it is possible to detect even the smallest nodules. The prevalence rate among the elderly population…
Relevance: Genetic factors play a significant role in the development of type 2 diabetes. This study aims to analyze genetic polymorphisms across different populations to determine susceptibility to the disease and to…
Background. Research shows that excess weight negatively affects the development and progression of respiratory diseases. As the SARS-CoV-2 pandemic continues, it is important to understand how body mass index (BMI)…
Background. The Bethesda Classification for Reporting Thyroid Cytopathology (BSRTC) was developed in 2010 to provide a standardized framework for interpreting and reporting FNA…
Endocrine ophthalmopathy is an autoimmune disease often associated with thyroid dysfunction. It affects the tissues of the orbit and periorbital structures, causing their edema and degenerative changes. One of the most…
Relevance: Type 2 diabetes mellitus (DM) is a global epidemic associated with severe vascular complications development. Diabetic neuropathy is the most common chronic…
From numerous studies, it is known about the role of SGLT-2 inhibitors in reducing glycemia, cardio- and nephroprotection in patients with type 2 diabetes. SGLT-type 1 has been studied somewhat less, the management and…
Analysis of thyroid cancer incidence rates (by regions, age, gender, histological type of thyroid cancer and laboratory data) based on the data of RSSMPCE named after Academician Yo.Kh. Turakulov in 2010-2016.
Relevance. Type 2 diabetes mellitus (DM2) is a chronic disease that requires gradual intensification of therapy to control glycemia. Studies show that poor control lasts up to seven years, increasing the risk of…