Relevance: Type 2 diabetes mellitus (DM) is a global epidemic associated with severe vascular complications development. Diabetic neuropathy is the most common chronic complication of DM that worsens patients’ life quality and prognosis. Therefore, studies dealing with DM and diabetic neuropathy underlying mechanisms are extremely relevant. The review discusses current views on vitamin D role in glucose metabolism and inflammatory processes. It is reported that vitamin D deficiency can contribute to insulin resistance development, and change in vitamin D receptor activity or extra- and intracellular calcium concentration due to vitamin D deficiency can affect pancreatic β-cells function and lead to decrease in insulin production. Key pathogenic mechanisms of diabetic neuropathy as well as possible relationship between vitamin D deficiency and neuropathy development are in focus of this review. Results of recent clinical trials regarding vitamin D supplementation in patients with DM are also discussed. The presented data suggest that vitamin D deficiency can be considered as a non-classical risk factor for the development of not only DM but its complications as well.
| Mualliflar | Базарова Сайёра Абдувоситовна, Нажмутдинова Дилором Камаритдиновна, Кузиева Мамура Махмудовна |
|---|---|
| Jurnal | Марказий Осиё эндокринологик журнали |
| Nashr sanasi | 2025-01-24 |
| Jild | 4 |
| Son | 3 |
| Til | O‘zbek |
Диабет, диабетические осложнения, дефицит витамина D3, diabetes mellitus; diabetic neuropathy; vitamin D deficiency, Qandli diabet , diabetik asoratlar, Vitamin D 3 yetishmovchiligi
Analysis of thyroid cancer incidence rates (by regions, age, gender, histological type of thyroid cancer and laboratory data) based on the data of RSSMPCE named after Academician Yo.Kh. Turakulov in 2010-2016.
Background. The Bethesda Classification for Reporting Thyroid Cytopathology (BSRTC) was developed in 2010 to provide a standardized framework for interpreting and reporting FNA…
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Relevance: Genetic factors play a significant role in the development of type 2 diabetes. This study aims to analyze genetic polymorphisms across different populations to determine susceptibility to the disease and to…
Background. Thyroid nodules are often detected by ultrasound of the neck. Most nodules are benign; therefore, many nodes are biopsied to identify the small number of nodes that are malignant or require surgery for…
Purpose: To study the characteristics of diabetes occurring after contracting COVID-19. Methods: Hemostasis parameters, vitamin D levels, and beta cell-specific autoantibodies were tested in 70 patients with…
Thyroid nodules have received attention due to changes in population surveillance systems and growing concerns about the associated financial burden on health care systems, payers, and patients. In this review, we found…
Diabetic retinopathy (DR) is recognised as the leading cause of blindness and low vision among people of working age. Diagnosis and grading of the disease is…
The article highlights the role of vitamin B12 in patients with diabetes mellitus (DM) and diabetic polyneuropathy. The possible mechanisms for the development of vitamin B12 deficiency in patients with DM are…
Currently, thyroid gland (TG) diseases with nodular formations are widespread, and due to ultrasound examination, it is possible to detect even the smallest nodules. The prevalence rate among the elderly population…