The COVID-19 pandemic has revealed previously unrecognized clinical features of infectious and inflammatory kidney diseases in pediatric patients. Objective: To determine the significance of tubuloglomerular abnormalities biomarkers (γ-GT, β2M, NGAL, KIM-1) in clinical and laboratory diagnostics in children with acute pyelonephritis after COVID-19. Methods. The study included 100 children with clinically and laboratory-confirmed acute pyelonephritis. The control group consisted of 25 apparently healthy children, matched for age and gender. Results. The study results revealed a statistically significant increase in urinary γ-GT, KIM-1, NGAL, and β₂-microglobulin concentrations compared to the control group. In patients in the first group, γ-GT levels were 4.57 times higher than the control group, KIM-1 levels were 3.77 times higher, NGAL levels were 25.96 times higher, and β₂M levels were 7.64 times higher. Conclusion. Determining the concentrations of these parameters allows us to identify early signs of tubulointerstitial damage, assess the activity of the pathological process in the renal tubular apparatus, and identify risk groups for chronic pyelonephritis.
| Mualliflar | AKHMEDZHANOVA Nargiza Ismailovna, GANIEVA Marifat Shokirovna, MAJIDOVA Nilufar Mansuralievna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2026-04-24 |
| Jild | 11 |
| Son | 1 |
| Til | Ingliz |
постковидные осложнения, острый пиелонефрит, тубулоинтерстициальные поражения, KIM-1, NGAL, β₂-микроглобулин, γ-ГТ, : Acute cholecystitis, navigational surgery, surgical and anesthetic risk, percutaneous transhepatic microcholecystostomy, endoscopic papilosphincterotomy
The choice of treatment strategy for dolichosigma requires an individualized approach based on a comprehensive analysis of the clinical and functional state of the intestine. The effectiveness of conservative therapy…
To perform a comparative evaluation of the effectiveness of endoscopic correction methods (STING, HIT-1, HIT-2) in the treatment of patients with primary high-grade vesicoureteral reflux. A total of 65 patients (39…
A retrospective study of 29 children aged 3 months to 17 years treated from 2019 to 2025 was performed. Chest radiography and multislice computed tomography were used for diagnosis. Unilateral involvement was detected…
Background: Acute rheumatic fever (ARF) remains a significant pediatric health concern in developing countries. Recent studies suggest that vitamin D plays an important immunomodulatory role in inflammatory diseases…
Kidney stone disease in children is a multifactorial disease based on persistent metabolic disorders, which determine a high risk of recurrence even after successful removal of concretions. Modern minimally invasive…
Soft tissue necrosis in children is a severe pathological condition that develops under the influence of traumatic, infectious, ischemic, or toxic factors. Although relatively rare, this condition is characterized by…
Ibragimova Sapura Zakhidovna, Almedova Nargiza Nigmatjonovna, Botirov Mirzokhid Mansurzhon Ugli, Shadibekova Oksana Borisovna, Aripova Nazokat Bahodirovna, Erimbetova Indira Oralbaevna. Results of the use of emicizumab…
The complexity of treatment and rehabilitation of patients with open bifocal comminuted long bone fractures with extensive bone tissue defects is due to the combination of an increased risk of infectious complications…
The results of this study confirm the feasibility of a comprehensive assessment of vitamin D and CRP levels in young children with recurrent respiratory tract infections in a hospital setting. Vitamin D deficiency and…
Проанализированы результаты лечения 95 пациентов в возрасте от 1 года до 18 лет. В зависимости от метода лечения больные были разделены на 2 группы. В основной группе применяли закрытую репозицию и фиксацию переломов…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar