Innovative methods of early diagnosis of tubulointerstitial lesions in acute pyelonephritis in children

AKHMEDZHANOVA Nargiza Ismailovna, GANIEVA Marifat Shokirovna, MAJIDOVA Nilufar Mansuralievna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

The COVID-19 pandemic has revealed previously unrecognized clinical features of infectious and inflammatory kidney diseases in pediatric patients. Objective: To determine the significance of tubuloglomerular abnormalities biomarkers (γ-GT, β2M, NGAL, KIM-1) in clinical and laboratory diagnostics in children with acute pyelonephritis after COVID-19. Methods. The study included 100 children with clinically and laboratory-confirmed acute pyelonephritis. The control group consisted of 25 apparently healthy children, matched for age and gender. Results. The study results revealed a statistically significant increase in urinary γ-GT, KIM-1, NGAL, and β₂-microglobulin concentrations compared to the control group. In patients in the first group, γ-GT levels were 4.57 times higher than the control group, KIM-1 levels were 3.77 times higher, NGAL levels were 25.96 times higher, and β₂M levels were 7.64 times higher. Conclusion. Determining the concentrations of these parameters allows us to identify early signs of tubulointerstitial damage, assess the activity of the pathological process in the renal tubular apparatus, and identify risk groups for chronic pyelonephritis.

Maqola ma’lumotlari
MualliflarAKHMEDZHANOVA Nargiza Ismailovna, GANIEVA Marifat Shokirovna, MAJIDOVA Nilufar Mansuralievna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-04-24
Jild11
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

постковидные осложнения, острый пиелонефрит, тубулоинтерстициальные поражения, KIM-1, NGAL, β₂-микроглобулин, γ-ГТ, : Acute cholecystitis, navigational surgery, surgical and anesthetic risk, percutaneous transhepatic microcholecystostomy, endoscopic papilosphincterotomy

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAAKHMEDZHANOVA Nargiza Ismailovna, GANIEVA Marifat Shokirovna, & MAJIDOVA Nilufar Mansuralievna (2026). INNOVATIVE METHODS OF EARLY DIAGNOSIS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13503
GOST (OAK)AKHMEDZHANOVA Nargiza Ismailovna, GANIEVA Marifat Shokirovna, MAJIDOVA Nilufar Mansuralievna INNOVATIVE METHODS OF EARLY DIAGNOSIS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 1.
MLAAKHMEDZHANOVA Nargiza Ismailovna, GANIEVA Marifat Shokirovna, and MAJIDOVA Nilufar Mansuralievna. “INNOVATIVE METHODS OF EARLY DIAGNOSIS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13503
ChicagoAKHMEDZHANOVA Nargiza Ismailovna, GANIEVA Marifat Shokirovna, and MAJIDOVA Nilufar Mansuralievna. “INNOVATIVE METHODS OF EARLY DIAGNOSIS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13503
HarvardAKHMEDZHANOVA Nargiza Ismailovna, GANIEVA Marifat Shokirovna, and MAJIDOVA Nilufar Mansuralievna (2026) ‘INNOVATIVE METHODS OF EARLY DIAGNOSIS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13503
BibTeX
@article{akhmedzhanovanargizaismailovna2026,
  title = {INNOVATIVE METHODS OF EARLY DIAGNOSIS OF TUBULOINTERSTITIAL LESIONS IN ACUTE PYELONEPHRITIS IN CHILDREN},
  author = {AKHMEDZHANOVA Nargiza Ismailovna and GANIEVA Marifat Shokirovna and MAJIDOVA Nilufar Mansuralievna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13503}
}

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