Results of the use of emicizumab in patients with hemophilia a – a pilot single-center study

IBRAGIMOVA Sapura Zakhidovna, ALMEDOVA Nargiza Nigmatjonovna, BOTIROV Mirzokhid Mansurzhon ugli, SHADIBEKOVA Oksana Borisovna, ARIPOVA Nazokat Bahodirovna, ERIMBETOVA Indira Oralbaevna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Ibragimova Sapura Zakhidovna, Almedova Nargiza Nigmatjonovna, Botirov Mirzokhid Mansurzhon Ugli, Shadibekova Oksana Borisovna, Aripova Nazokat Bahodirovna, Erimbetova Indira Oralbaevna. Results of the use of emicizumab in patients with hemophilia A – a pilot single-center study // Journal of Biomedicine and Practice. 2026, vol. 11, issue 1. Resume. It is known that patients with severe hemophilia A, a hereditary bleeding disorder caused by a deficiency of coagulation factor VIII, often experience uncontrolled bleeding, which occurs despite the administration of prophylactic replacement therapy with coagulation factors. Such conditions are characteristic of the inhibitor form of hemophilia A [1,2]. An inhibitor is a polyclonal high-affinity IgG antibody that specifically neutralizes the procoagulant activity of coagulation factors, making bleeding management difficult. The emergence of inhibitors is associated with a worsening prognosis: a higher incidence of bleeding, accelerated development of arthropathy, and a decrease in quality of life. In more severe cases, this could lead to the death of children [3,6]. In order to prevent the above-mentioned conditions, improve the quality of life of patients and prevent complications of the disease, the Scientific and Practical Medical Center for Pediatric Hematology, Oncology and Immunology used the "Hemlibra" (emicizumab) in 15 children with hereditary bleeding disorder caused by the inhibitory form of coagulation factor VIII deficiency.

Maqola ma’lumotlari
MualliflarIBRAGIMOVA Sapura Zakhidovna, ALMEDOVA Nargiza Nigmatjonovna, BOTIROV Mirzokhid Mansurzhon ugli, SHADIBEKOVA Oksana Borisovna, ARIPOVA Nazokat Bahodirovna, ERIMBETOVA Indira Oralbaevna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-04-24
Jild11
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

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Kalit so‘zlar

эмицизумаб, гемофилия А, фактор свёртывания крови VIII, ингибитор фактора свёртывания крови VIII, одностадийный клоттинговый метод, хромогенный метод, emicizumab, hemophilia A, coagulation factor VIII, coagulation factor VIII inhibitor, one-step clotting method, chromogenic method, emizizumab, gemofiliya A, VIII omil, VIII omil ingibitori, bir bosqichli ivish usuli, xromogen usul

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APAIBRAGIMOVA Sapura Zakhidovna, ALMEDOVA Nargiza Nigmatjonovna, BOTIROV Mirzokhid Mansurzhon ugli, SHADIBEKOVA Oksana Borisovna, ARIPOVA Nazokat Bahodirovna, & ERIMBETOVA Indira Oralbaevna (2026). RESULTS OF THE USE OF EMICIZUMAB IN PATIENTS WITH HEMOPHILIA A – A PILOT SINGLE-CENTER STUDY. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13507
GOST (OAK)IBRAGIMOVA Sapura Zakhidovna va b. RESULTS OF THE USE OF EMICIZUMAB IN PATIENTS WITH HEMOPHILIA A – A PILOT SINGLE-CENTER STUDY // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 1.
MLAIBRAGIMOVA Sapura Zakhidovna, ALMEDOVA Nargiza Nigmatjonovna, BOTIROV Mirzokhid Mansurzhon ugli, SHADIBEKOVA Oksana Borisovna, ARIPOVA Nazokat Bahodirovna, and ERIMBETOVA Indira Oralbaevna. “RESULTS OF THE USE OF EMICIZUMAB IN PATIENTS WITH HEMOPHILIA A – A PILOT SINGLE-CENTER STUDY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13507
ChicagoIBRAGIMOVA Sapura Zakhidovna, ALMEDOVA Nargiza Nigmatjonovna, BOTIROV Mirzokhid Mansurzhon ugli, SHADIBEKOVA Oksana Borisovna, ARIPOVA Nazokat Bahodirovna, and ERIMBETOVA Indira Oralbaevna. “RESULTS OF THE USE OF EMICIZUMAB IN PATIENTS WITH HEMOPHILIA A – A PILOT SINGLE-CENTER STUDY.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13507
HarvardIBRAGIMOVA Sapura Zakhidovna, ALMEDOVA Nargiza Nigmatjonovna, BOTIROV Mirzokhid Mansurzhon ugli, SHADIBEKOVA Oksana Borisovna, ARIPOVA Nazokat Bahodirovna, and ERIMBETOVA Indira Oralbaevna (2026) ‘RESULTS OF THE USE OF EMICIZUMAB IN PATIENTS WITH HEMOPHILIA A – A PILOT SINGLE-CENTER STUDY’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13507
BibTeX
@article{ibragimovasapurazakhidovna2026,
  title = {RESULTS OF THE USE OF EMICIZUMAB IN PATIENTS WITH HEMOPHILIA A – A PILOT SINGLE-CENTER STUDY},
  author = {IBRAGIMOVA Sapura Zakhidovna and ALMEDOVA Nargiza Nigmatjonovna and BOTIROV Mirzokhid Mansurzhon ugli and SHADIBEKOVA Oksana Borisovna and ARIPOVA Nazokat Bahodirovna and ERIMBETOVA Indira Oralbaevna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13507}
}

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