Assessment of the immun system status in acute destructive pancreatitis

ABDURAHMONOV Ma’mur, UMEDOV Xushvaqt Alisherovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

To assess the degree of immunodeficiency in acute destructive pancreatitis.This study is based on the results of a prospective examination of 97 patients with acute pancreatitis who were treated in the surgical departments of the Samarkand branch of republican research center of emergency medicine from 2020 to 2025. The diagnostic and therapeutic procedures were carried out in accordance with the protocols for the diagnosis and treatment of acute pancreatitis. In the destructive form of acute pancreatitis, the absolute number of T-lymphocytes decreased from 0.97±0.03 to 0.43±0.06 g/l, and in percentage terms - from 55.9% to 50.9%. This indicates a pronounced immunodeficiency due to a reduction in T-helpers. The slight decrease in T-suppressors was not statistically significant. The number of NK cells remained within normal limits. The immunoregulatory index (IRI) decreased significantly, indicating marked cellular immunodeficiency. No statistically significant changes were observed in the phagocytic component. Circulating immune complexes (CIC) were slightly reduced at the time of examination. The nature and degree of immunodeficiency are directly related to the severity of the disease. It should be noted that there is a correlation between the level of immunodeficiency and the volume of pancreatic necrosis. As evidence of this relationship, the simultaneous manifestation of two processes - the formation of pancreatic necrosis foci and the appearance of signs of immunodeficiency was observed within the first 48 hours after the onset of acute pancreatitis.

Maqola ma’lumotlari
MualliflarABDURAHMONOV Ma’mur, UMEDOV Xushvaqt Alisherovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-04-24
Jild11
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

острый панкреатит, иммунодефицит, тяжёлое течение., acute pancreatitis, immunodeficiency, hard course, O’tkir pankreatit, immunodefitsit, og’ir kechishi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAABDURAHMONOV Ma’mur, & UMEDOV Xushvaqt Alisherovich (2026). ASSESSMENT OF THE IMMUN SYSTEM STATUS IN ACUTE DESTRUCTIVE PANCREATITIS. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13509
GOST (OAK)ABDURAHMONOV Ma’mur, UMEDOV Xushvaqt Alisherovich ASSESSMENT OF THE IMMUN SYSTEM STATUS IN ACUTE DESTRUCTIVE PANCREATITIS // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 1.
MLAABDURAHMONOV Ma’mur, and UMEDOV Xushvaqt Alisherovich. “ASSESSMENT OF THE IMMUN SYSTEM STATUS IN ACUTE DESTRUCTIVE PANCREATITIS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13509
ChicagoABDURAHMONOV Ma’mur, and UMEDOV Xushvaqt Alisherovich. “ASSESSMENT OF THE IMMUN SYSTEM STATUS IN ACUTE DESTRUCTIVE PANCREATITIS.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13509
HarvardABDURAHMONOV Ma’mur, and UMEDOV Xushvaqt Alisherovich (2026) ‘ASSESSMENT OF THE IMMUN SYSTEM STATUS IN ACUTE DESTRUCTIVE PANCREATITIS’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13509
BibTeX
@article{abdurahmonovmamur2026,
  title = {ASSESSMENT OF THE IMMUN SYSTEM STATUS IN ACUTE DESTRUCTIVE PANCREATITIS},
  author = {ABDURAHMONOV Ma’mur and UMEDOV Xushvaqt Alisherovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13509}
}

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