Vitamin d deficiency as a predictor of inflammatory activity in children with acute rheumatic fever

UMAROVA Saodat Sulaymonovna

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2026-yil

Annotatsiya

Background: Acute rheumatic fever (ARF) remains a significant pediatric health concern in developing countries. Recent studies suggest that vitamin D plays an important immunomodulatory role in inflammatory diseases. Objective: To investigate the relationship between vitamin D deficiency and inflammatory cytokines (IL-1β, IL-6, IL-8, IFN-γ) in children with acute rheumatic fever.Methods: The study included 60 children aged 5–15 years diagnosed with ARF. As part of this study, the concentration of 25(OH)D in children with acute rheumatic fever (ARF) was evaluated and compared with data from healthy children of the same age group. Serum levels of 25(OH)D and proinflammatory cytokines were measured before and after treatment. Vitamin D levels were assessed by ELISA, and cytokines were determined using Vector-Best immunoassays.Results: A significant inverse correlation was observed between serum vitamin D levels and IL-6 concentrations (r = -0.42, p < 0.05). The majority of children with severe carditis presented with pronounced vitamin D deficiency and elevated IL-6 and IFN-γ levels. After treatment, cytokine levels decreased while vitamin D status modestly improved.Conclusion: Vitamin D deficiency may serve as a predictor of inflammatory activity in ARF and correlates with elevated proinflammatory cytokines, particularly IL-6. Assessing vitamin D status may help in the early detection of immune-mediated activity in children with ARF and guide preventive and therapeutic strategies.

Maqola ma’lumotlari
MualliflarUMAROVA Saodat Sulaymonovna
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2026-04-24
Jild11
Son1
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

острая ревматическая лихорадка, дефицит витамина D, ИЛ-6, цитокины, дети, воспаление, иммунный ответ, o'tkir revmatik isitma, D vitamini yetishmovchiligi, IL-6, sitokinlar, bolalar, yallig'lanish, immun javob

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUMAROVA Saodat Sulaymonovna (2026). VITAMIN D DEFICIENCY AS A PREDICTOR OF INFLAMMATORY ACTIVITY IN CHILDREN WITH ACUTE RHEUMATIC FEVER. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13501
GOST (OAK)UMAROVA Saodat Sulaymonovna VITAMIN D DEFICIENCY AS A PREDICTOR OF INFLAMMATORY ACTIVITY IN CHILDREN WITH ACUTE RHEUMATIC FEVER // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2026. – T. 11, № 1.
MLAUMAROVA Saodat Sulaymonovna. “VITAMIN D DEFICIENCY AS A PREDICTOR OF INFLAMMATORY ACTIVITY IN CHILDREN WITH ACUTE RHEUMATIC FEVER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1), 2026. https://tadqiqot.uz/index.php/biomedicine/article/view/13501
ChicagoUMAROVA Saodat Sulaymonovna. “VITAMIN D DEFICIENCY AS A PREDICTOR OF INFLAMMATORY ACTIVITY IN CHILDREN WITH ACUTE RHEUMATIC FEVER.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1) (2026). https://tadqiqot.uz/index.php/biomedicine/article/view/13501
HarvardUMAROVA Saodat Sulaymonovna (2026) ‘VITAMIN D DEFICIENCY AS A PREDICTOR OF INFLAMMATORY ACTIVITY IN CHILDREN WITH ACUTE RHEUMATIC FEVER’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 11(1). https://tadqiqot.uz/index.php/biomedicine/article/view/13501
BibTeX
@article{umarovasaodatsulaymonovna2026,
  title = {VITAMIN D DEFICIENCY AS A PREDICTOR OF INFLAMMATORY ACTIVITY IN CHILDREN WITH ACUTE RHEUMATIC FEVER},
  author = {UMAROVA Saodat Sulaymonovna},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2026},
  volume = {11},
  number = {1},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13501}
}

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