The role of ulinastatin in comprehensive therapy for the prevention of postoperative complications in coronary artery bypass grafting

MATLUBOV Mansur Muratovich, YUSUPOV Jasur Tolibovich, KHAMDAMOVA Eleanora Gafarovna, KHAMDAMOV Olim Dilmurodovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

Nowadays coronary artery bypass grafting remains the main treatment method for multivessel coronary artery disease caused by ischemic heart disease. Postoperative complications significantly prolong patients’ stay in intensive care units. The study included 160 patients after coronary artery bypass grafting, divided into two groups. In the main group (80 patients), the diagnostic and therapeutic process was supplemented by multifactorial risk prediction of early complications and the use of ulinastatin as anti-inflammatory therapy. In the control group (80 patients), standard management was applied. Patients in the main group were divided into subgroups according to the prognostic scale: patients with low, moderate, high, and very high risk of postoperative complicationsю Seventy-two hours after surgery, patients with very high risk demonstrated hyperthermia and pneumonia in 10–12% of cases; acute respiratory distress syndrome and multiple organ dysfunction syndrome occurred in 1–4%, leading to mortality in 2.5% of the control group. Suppurative wound complications and mediastinitis were less frequent in the main group compared with the control. The findings confirm the effectiveness of multifactorial risk prediction and the use of ulinastatin in reducing the incidence of early postoperative complications after coronary artery bypass grafting.

Maqola ma’lumotlari
MualliflarMATLUBOV Mansur Muratovich, YUSUPOV Jasur Tolibovich, KHAMDAMOVA Eleanora Gafarovna, KHAMDAMOV Olim Dilmurodovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-12-03
Jild10
Son5
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

аортокоронарное шунтирование, послеоперационные осложнение, улинастатин, шкала прогнозирования, coronary artery bypass grafting, postoperative complications, ulinastatin, risk prediction scale, aortokoronar shuntlash, ulinitatin, operatsiyadan keyingi asoratlar, prognozlash shkalasi

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAMATLUBOV Mansur Muratovich, YUSUPOV Jasur Tolibovich, KHAMDAMOVA Eleanora Gafarovna, & KHAMDAMOV Olim Dilmurodovich (2025). THE ROLE OF ULINASTATIN IN COMPREHENSIVE THERAPY FOR THE PREVENTION OF POSTOPERATIVE COMPLICATIONS IN CORONARY ARTERY BYPASS GRAFTING. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/13015
GOST (OAK)MATLUBOV Mansur Muratovich va b. THE ROLE OF ULINASTATIN IN COMPREHENSIVE THERAPY FOR THE PREVENTION OF POSTOPERATIVE COMPLICATIONS IN CORONARY ARTERY BYPASS GRAFTING // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 5.
MLAMATLUBOV Mansur Muratovich, YUSUPOV Jasur Tolibovich, KHAMDAMOVA Eleanora Gafarovna, and KHAMDAMOV Olim Dilmurodovich. “THE ROLE OF ULINASTATIN IN COMPREHENSIVE THERAPY FOR THE PREVENTION OF POSTOPERATIVE COMPLICATIONS IN CORONARY ARTERY BYPASS GRAFTING.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/13015
ChicagoMATLUBOV Mansur Muratovich, YUSUPOV Jasur Tolibovich, KHAMDAMOVA Eleanora Gafarovna, and KHAMDAMOV Olim Dilmurodovich. “THE ROLE OF ULINASTATIN IN COMPREHENSIVE THERAPY FOR THE PREVENTION OF POSTOPERATIVE COMPLICATIONS IN CORONARY ARTERY BYPASS GRAFTING.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/13015
HarvardMATLUBOV Mansur Muratovich, YUSUPOV Jasur Tolibovich, KHAMDAMOVA Eleanora Gafarovna, and KHAMDAMOV Olim Dilmurodovich (2025) ‘THE ROLE OF ULINASTATIN IN COMPREHENSIVE THERAPY FOR THE PREVENTION OF POSTOPERATIVE COMPLICATIONS IN CORONARY ARTERY BYPASS GRAFTING’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/13015
BibTeX
@article{matlubovmansurmuratovich2025,
  title = {THE ROLE OF ULINASTATIN IN COMPREHENSIVE THERAPY FOR THE PREVENTION OF POSTOPERATIVE COMPLICATIONS IN CORONARY ARTERY BYPASS GRAFTING},
  author = {MATLUBOV Mansur Muratovich and YUSUPOV Jasur Tolibovich and KHAMDAMOVA Eleanora Gafarovna and KHAMDAMOV Olim Dilmurodovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {5},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13015}
}

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