Personalized algorithm for immunocorrection in patients with generalized peritonitis and high immunological risk

RAKHIMOV Oybek Umarovich, KHAMDAMOV Bakhtiyor Zarifovich, DADAYEV Shirin Amanovich

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali · 2025-yil

Annotatsiya

Background. Generalized peritonitis is associated with a high rate of adverse outcomes; empirical immunocorrection without risk stratification limits clinical effectiveness. A reproducible algorithm is needed to link the clinical–immunological profile to the intensity of immunomodulation. Aim. To clinically substantiate a personalized immunocorrection algorithm for patients with generalized peritonitis at high or critical immunological risk. Materials and Methods. Single-center prospective study (n = 60). On postoperative day 1, immunological stratification (CD4⁺, NK, IgM, circulating immune complexes [CIC], IL-6/IL-10) assigned patients to low, high, or critical risk; the present analysis focused on the high- and critical-risk groups. The algorithm specified basic or extended immunocorrection with checkpoints on days 3 and 7, allowing escalation/de-escalation. Statistical analysis used non-parametric tests and descriptive analytics. Results. Stratification yielded: low — 18 (30.0%), high — 26 (43.3%), critical — 16 (26.7%). Therapeutic routing was guided by clinical–immunological indicators and aligned with the initial clinical phase: in the critical-risk group, the terminal phase predominated and the reactive phase was absent; in the high-risk group, the toxic phase predominated. The algorithm proved operationally manageable owing to predefined checkpoints and escalation criteria. Conclusion. The personalized algorithm enables standardized, profile-driven decision-making on immunocorrection and improves treatment controllability. Before integration into clinical protocols, multicenter validation, harmonization of escalation/de-escalation thresholds, and formalization of risk-category calculation rules are required.

Maqola ma’lumotlari
MualliflarRAKHIMOV Oybek Umarovich, KHAMDAMOV Bakhtiyor Zarifovich, DADAYEV Shirin Amanovich
JurnalJournal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali
NashriyotТошкент давлат стоматалогия институти, , «Expert Lawyers» MЧЖ
ISSN2181-9300
Nashr sanasi2025-12-03
Jild10
Son5
TilIngliz
Ilmiy sohaTibbiyot
Indeksga qo‘shilgan2026-08-27

Maqolaning asl sahifasi

Kalit so‘zlar

распространённый перитонит, иммунологический риск, персонализированная иммунокоррекция, цитокиновый профиль, клинический алгоритм, generalized peritonitis, immunological risk, personalized immunocorrection, cytokine profile, clinical algorithm, tarqalgan peritonit, immunologik xavf, shaxsiylashtirilgan immunokorreksiya, sitokin profili, klinik algoritm

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APARAKHIMOV Oybek Umarovich, KHAMDAMOV Bakhtiyor Zarifovich, & DADAYEV Shirin Amanovich (2025). PERSONALIZED ALGORITHM FOR IMMUNOCORRECTION IN PATIENTS WITH GENERALIZED PERITONITIS AND HIGH IMMUNOLOGICAL RISK. Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/13016
GOST (OAK)RAKHIMOV Oybek Umarovich, KHAMDAMOV Bakhtiyor Zarifovich, DADAYEV Shirin Amanovich PERSONALIZED ALGORITHM FOR IMMUNOCORRECTION IN PATIENTS WITH GENERALIZED PERITONITIS AND HIGH IMMUNOLOGICAL RISK // Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali. – 2025. – T. 10, № 5.
MLARAKHIMOV Oybek Umarovich, KHAMDAMOV Bakhtiyor Zarifovich, and DADAYEV Shirin Amanovich. “PERSONALIZED ALGORITHM FOR IMMUNOCORRECTION IN PATIENTS WITH GENERALIZED PERITONITIS AND HIGH IMMUNOLOGICAL RISK.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5), 2025. https://tadqiqot.uz/index.php/biomedicine/article/view/13016
ChicagoRAKHIMOV Oybek Umarovich, KHAMDAMOV Bakhtiyor Zarifovich, and DADAYEV Shirin Amanovich. “PERSONALIZED ALGORITHM FOR IMMUNOCORRECTION IN PATIENTS WITH GENERALIZED PERITONITIS AND HIGH IMMUNOLOGICAL RISK.” Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5) (2025). https://tadqiqot.uz/index.php/biomedicine/article/view/13016
HarvardRAKHIMOV Oybek Umarovich, KHAMDAMOV Bakhtiyor Zarifovich, and DADAYEV Shirin Amanovich (2025) ‘PERSONALIZED ALGORITHM FOR IMMUNOCORRECTION IN PATIENTS WITH GENERALIZED PERITONITIS AND HIGH IMMUNOLOGICAL RISK’, Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali, 10(5). https://tadqiqot.uz/index.php/biomedicine/article/view/13016
BibTeX
@article{rakhimovoybekumarovich2025,
  title = {PERSONALIZED ALGORITHM FOR IMMUNOCORRECTION IN PATIENTS WITH GENERALIZED PERITONITIS AND HIGH IMMUNOLOGICAL RISK},
  author = {RAKHIMOV Oybek Umarovich and KHAMDAMOV Bakhtiyor Zarifovich and DADAYEV Shirin Amanovich},
  journal = {Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali},
  year = {2025},
  volume = {10},
  number = {5},
  url = {https://tadqiqot.uz/index.php/biomedicine/article/view/13016}
}

Boshqa maqola uchun iqtibos tayyorlash

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali jurnalidan boshqa maqolalar

Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar · 2025-yil arxivi

Tibbiyot sohasidagi boshqa maqolalar

Tibbiyot sohasidagi OAK jurnallari