Functional hypothalamic amenorrhea (FHA) is a common cause of secondary amenorrhea in women of reproductive age, resulting from suppression of gonadotropin-releasing hormone (GnRH) secretion due to stress, energy deficiency, and psychosocial factors. This review summarizes current concepts of FHA pathogenesis, emphasizing the central role of kisspeptin and metabolic hormones in hypothalamic-pituitary-gonadal axis regulation. Clinical manifestations, diagnostic principles, and modern therapeutic strategies are discussed. Particular attention is paid to multidisciplinary approaches aimed at restoring energy balance, reducing stress, and implementing cognitive-behavioral therapy. Emerging treatments, including kisspeptin receptor agonists and leptin-based interventions, show promise for restoring ovulatory function and reproductive health.
| Mualliflar | AKHMEDJANOVA Saodat Fakhadovna |
|---|---|
| Jurnal | Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali |
| Nashr sanasi | 2025-12-03 |
| Jild | 10 |
| Son | 5 |
| Til | Rus |
функциональная гипоталамическая аменорея, kisspeptin, GnRH, стресс, энергетический дефицит, гипоэстрогения, фертильность, functional hypothalamic amenorrhea, kisspeptin, GnRH, stress, energy deficiency, hypoestrogenism, fertility, funktsional gipotalamik amenoreya, kisspeptin, GnRH, stress, energiya tanqisligi, gipooestrogeniya, fertilitet.
Objective: To conduct a comprehensive assessment of the diagnostic efficacy of compression sonoelastography in differential diagnosis of choroidal neoplasms. Materials and Methods: 17 patients with intraocular tumors…
Managing postprandial glycemia is a key objective in the treatment of patients with type 2 diabetes mellitus (T2DM). International organizations, such as the FAO and the American Diabetes Association, recommend…
In recent years, patient expectations regarding the outcomes of refractive surgery have significantly increased. Achieving high visual acuity alone is no longer sufficient; subjective visual quality under various…
This publication presents an analysis of our own results from clinical-neurological, neuropsychological, and neuroimaging studies devoted to the problem of mnemonic dysfunctions in children and adolescents with type 1…
In this state, the data of orthokeratological lens analysis and control of the progression of close-sightedness are detected. The aim of the study is to summarize and critically evaluate the clinical data on the…
Wolfram syndrome and Alström syndrome are rare monogenic autosomal recessive multisystem disorders that manifest in childhood or adolescence. Despite certain overlapping clinical features (such as early-onset diabetes…
This article examines the results of Friedenwald tonography, as well as a comparison of Maklakov and I-Care tonometry in children with congenital glaucoma. Dynamic monitoring of tonographic and tonometric parameters…
Crohn's Disease (CD) is characterized by a chronic, slowly progressing course, with localization of the pathological process in any part of the gastrointestinal tract. It is typical for young individuals, most…
The aim of the study was to identify key diagnostic measures to reduce the risk of complications of varicose veins in pregnant women, such as thrombosis and inflammatory processes in the veins. The study involved 100…
Background. Generalized peritonitis is associated with a high rate of adverse outcomes; empirical immunocorrection without risk stratification limits clinical effectiveness. A reproducible algorithm is needed to link…
Journal of Biomedicine and Practice – Biomeditsina va amaliyot jurnali — barcha maqolalar