Aim. To perform a comparative analysis of immunohistochemical data in patients with macro- and giant non-functional pituitary adenomas (NFPA). Materials and methods. Twenty patients with NFPA were studied: group 1 included 10 pituitary macroadenomas and group 2 included 10 giant pituitary adenomas. All patients underwent transnasal pituitary adenomectomy and a standardized diagnostic protocol that included fundus examination, visual-field testing every 3 months, and laboratory assays (STH, IGF-1, LH, FSH, ACTH, TSH, prolactin, free thyroxine, cortisol). Resected specimens were examined immunohistochemically with determination of Ki-67 and p53 expression. Results. The odds of an aggressive NFPA phenotype were 8.2 times higher (p < 0.001) when invasive growth was present (sensitivity 86%, specificity 53%, Youden index 0.45, accuracy 66%). Per-percentage-point increases in marker expression were strongly associated with aggressiveness: a coefficient of 5.2 per percentage point for the Ki-67–positive tumor-cell nuclei (p < 0.001) and 3.1 per percentage point for p53-immunopositive nuclei (p < 0.001). Conclusions. Significant threshold values were identified: p53 ≥ 2% (reported CI: 0.94) and a Ki-67 labelling index ≥ 4% (reported CI: 0.98), the latter being the most reliable individual marker for differentiating macro NFPA from giant NFPA. Tumors with immunoexpression of at least two markers were observed in 54% of the cohort and were classified as aggressive adenomas. By marker counts: p53-positive cases—4 in group 1 and 5 in group 2; Ki-67 ≥ 4%—5 in group 1 and 6 in group 2. Overall, 11 of 20 IHC-examined patients were assessed as having a risk of growth recurrence.
| Mualliflar | Urmanova, Yulduz, Урманова, Юлдуз, Urmanova, Yulduz |
|---|---|
| Jurnal | Жамият ва инновациялар / Общество и инновации / Society and innovations |
| Nashr sanasi | 2025-11-25 |
| Jild | 6 |
| Son | 11/S |
| Betlar | 1-9 |
| Til | Rus |
| DOI | 10.47689/2181-1415-vol6-iss11/s-pp1-9 |
DOI: 10.47689/2181-1415-vol6-iss11/s-pp1-9 · Maqolaning asl sahifasi
НАГ, ИГХ, маркеры пролиферации, NFPA, IHC, proliferation markers, NFGA, IHC, proliferatsiya belgilari
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