Results of immunohistochemical studies in groups of patients with macro- and giant non-functioning pituitary adenomas after transnasal selective adenomectomy

Urmanova, Yulduz, Урманова, Юлдуз, Urmanova, Yulduz

Жамият ва инновациялар / Общество и инновации / Society and innovations · 2025-yil

Annotatsiya

Aim. To perform a comparative analysis of immunohistochemical data in patients with macro- and giant non-functional pituitary adenomas (NFPA). Materials and methods. Twenty patients with NFPA were studied: group 1 included 10 pituitary macroadenomas and group 2 included 10 giant pituitary adenomas. All patients underwent transnasal pituitary adenomectomy and a standardized diagnostic protocol that included fundus examination, visual-field testing every 3 months, and laboratory assays (STH, IGF-1, LH, FSH, ACTH, TSH, prolactin, free thyroxine, cortisol). Resected specimens were examined immunohistochemically with determination of Ki-67 and p53 expression. Results. The odds of an aggressive NFPA phenotype were 8.2 times higher (p < 0.001) when invasive growth was present (sensitivity 86%, specificity 53%, Youden index 0.45, accuracy 66%). Per-percentage-point increases in marker expression were strongly associated with aggressiveness: a coefficient of 5.2 per percentage point for the Ki-67–positive tumor-cell nuclei (p < 0.001) and 3.1 per percentage point for p53-immunopositive nuclei (p < 0.001). Conclusions. Significant threshold values were identified: p53 ≥ 2% (reported CI: 0.94) and a Ki-67 labelling index ≥ 4% (reported CI: 0.98), the latter being the most reliable individual marker for differentiating macro NFPA from giant NFPA. Tumors with immunoexpression of at least two markers were observed in 54% of the cohort and were classified as aggressive adenomas. By marker counts: p53-positive cases—4 in group 1 and 5 in group 2; Ki-67 ≥ 4%—5 in group 1 and 6 in group 2. Overall, 11 of 20 IHC-examined patients were assessed as having a risk of growth recurrence.

Maqola ma’lumotlari
MualliflarUrmanova, Yulduz, Урманова, Юлдуз, Urmanova, Yulduz
JurnalЖамият ва инновациялар / Общество и инновации / Society and innovations
NashriyotIn Science МЧЖ
ISSN2181-1415
Nashr sanasi2025-11-25
Jild6
Son11/S
Betlar1-9
TilIngliz
Ilmiy sohaTibbiyot
DOI10.47689/2181-1415-vol6-iss11/s-pp1-9
Indeksga qo‘shilgan2026-08-26

DOI: 10.47689/2181-1415-vol6-iss11/s-pp1-9 · Maqolaning asl sahifasi

Kalit so‘zlar

НАГ, ИГХ, маркеры пролиферации, NFPA, IHC, proliferation markers, NFGA, IHC, proliferatsiya belgilari

Ilmiy soha

Tibbiyot

Iqtibos keltirish

APAUrmanova, Yulduz, Урманова, Юлдуз, & Urmanova, Yulduz (2025). Results of immunohistochemical studies in groups of patients with macro- and giant non-functioning pituitary adenomas after transnasal selective adenomectomy. Жамият ва инновациялар / Общество и инновации / Society and innovations, 6(11/S), 1-9. https://doi.org/10.47689/2181-1415-vol6-iss11/s-pp1-9
GOST (OAK)Urmanova, Yulduz, Урманова, Юлдуз, Urmanova, Yulduz Results of immunohistochemical studies in groups of patients with macro- and giant non-functioning pituitary adenomas after transnasal selective adenomectomy // Жамият ва инновациялар / Общество и инновации / Society and innovations. – 2025. – T. 6, № 11/S. – P. 1-9. – DOI: 10.47689/2181-1415-vol6-iss11/s-pp1-9.
MLAUrmanova, Yulduz, Урманова, Юлдуз, and Urmanova, Yulduz. “Results of immunohistochemical studies in groups of patients with macro- and giant non-functioning pituitary adenomas after transnasal selective adenomectomy.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 6(11/S), 1-9, 2025. https://doi.org/10.47689/2181-1415-vol6-iss11/s-pp1-9
ChicagoUrmanova, Yulduz, Урманова, Юлдуз, and Urmanova, Yulduz. “Results of immunohistochemical studies in groups of patients with macro- and giant non-functioning pituitary adenomas after transnasal selective adenomectomy.” Жамият ва инновациялар / Общество и инновации / Society and innovations, 6(11/S), 1-9 (2025). https://doi.org/10.47689/2181-1415-vol6-iss11/s-pp1-9
HarvardUrmanova, Yulduz, Урманова, Юлдуз, and Urmanova, Yulduz (2025) ‘Results of immunohistochemical studies in groups of patients with macro- and giant non-functioning pituitary adenomas after transnasal selective adenomectomy’, Жамият ва инновациялар / Общество и инновации / Society and innovations, 6(11/S), 1-9. https://doi.org/10.47689/2181-1415-vol6-iss11/s-pp1-9
BibTeX
@article{urmanovayulduz2025,
  title = {Results of immunohistochemical studies in groups of patients with macro- and giant non-functioning pituitary adenomas after transnasal selective adenomectomy},
  author = {Urmanova, Yulduz and Урманова, Юлдуз and Urmanova, Yulduz},
  journal = {Жамият ва инновациялар / Общество и инновации / Society and innovations},
  year = {2025},
  volume = {6},
  number = {11/S},
  pages = {1-9},
  doi = {10.47689/2181-1415-vol6-iss11/s-pp1-9},
  url = {https://doi.org/10.47689/2181-1415-vol6-iss11/s-pp1-9}
}

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